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Endometrial small cell carcinoma

MedGen UID:
309057
•Concept ID:
C1516858
•
Neoplastic Process
Synonyms: Endometrial Small Cell Carcinoma; endometrial small cell carcinoma; Endometrial Small Cell Neuroendocrine Carcinoma; endometrium small cell carcinoma; small cell carcinoma of endometrium
 
Monarch Initiative: MONDO:0006197

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the endometrium. It is characterized by the presence of small malignant cells, necrotic changes, and an increased mitotic rate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEndometrial small cell carcinoma

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Discovery of STRO-002, a Novel Homogeneous ADC Targeting Folate Receptor Alpha, for the Treatment of Ovarian and Endometrial Cancers.
Li X, Zhou S, Abrahams CL, Krimm S, Smith J, Bajjuri K, Stephenson HT, Henningsen R, Hanson J, Heibeck TH, Calarese D, Tran C, Yin G, Stafford RL, Yam AY, Kline T, De Almeida VI, Sato AK, Lupher M, Bedard K, Hallam TJ
Mol Cancer Ther 2023 Feb 1;22(2):155-167. doi: 10.1158/1535-7163.MCT-22-0322. PMID: 36459691Free PMC Article
Incretin-based therapies in the treatment of type 2 diabetes--more than meets the eye?
Labuzek K, Kozłowski M, Szkudłapski D, Sikorska P, Kozłowska M, Okopień B
Eur J Intern Med 2013 Apr;24(3):207-12. Epub 2013 Jan 31 doi: 10.1016/j.ejim.2013.01.009. PMID: 23375875

Recent clinical studies

Etiology

Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Exfoliative cytology of neuroendocrine small cell carcinoma of the endometrium. A report of two cases.
Proca D, Keyhani-Rofagha S, Copeland LJ, Hameed A
Acta Cytol 1998 Jul-Aug;42(4):978-82. doi: 10.1159/000331980. PMID: 9684589

Diagnosis

Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases.
Sidibe FM, Traore Z, Georgala A, Kanab R, Larsimont D, Awada A, Piccart-Gebhart M
Bull Cancer 2018 Sep;105(9):842-846. Epub 2018 Jul 26 doi: 10.1016/j.bulcan.2018.06.007. PMID: 30057027
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
Marioni G, Savastano M, Mattiello L, Koussis H, Carpenè S, Marino F, Staffieri A
Am J Otolaryngol 2007 Jul-Aug;28(4):284-7. doi: 10.1016/j.amjoto.2006.09.011. PMID: 17606050
Rare case of small-cell carcinoma arising from the endometrium with paraneoplastic retinopathy.
Sekiguchi I, Suzuki M, Sato I, Ohkawa T, Kawashima H, Tsuchida S
Gynecol Oncol 1998 Dec;71(3):454-7. doi: 10.1006/gyno.1998.5049. PMID: 9887249
Exfoliative cytology of neuroendocrine small cell carcinoma of the endometrium. A report of two cases.
Proca D, Keyhani-Rofagha S, Copeland LJ, Hameed A
Acta Cytol 1998 Jul-Aug;42(4):978-82. doi: 10.1159/000331980. PMID: 9684589

Therapy

Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases.
Sidibe FM, Traore Z, Georgala A, Kanab R, Larsimont D, Awada A, Piccart-Gebhart M
Bull Cancer 2018 Sep;105(9):842-846. Epub 2018 Jul 26 doi: 10.1016/j.bulcan.2018.06.007. PMID: 30057027
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
Marioni G, Savastano M, Mattiello L, Koussis H, Carpenè S, Marino F, Staffieri A
Am J Otolaryngol 2007 Jul-Aug;28(4):284-7. doi: 10.1016/j.amjoto.2006.09.011. PMID: 17606050
Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis.
Meydanli MM, Erguvan R, Altinok MT, Ataoglu O, Kafkasli A
Tumori 2003 Mar-Apr;89(2):213-7. doi: 10.1177/030089160308900223. PMID: 12841676

Prognosis

Small cell carcinoma of the endometrium: A clinicopathological study and management of three cases.
Sidibe FM, Traore Z, Georgala A, Kanab R, Larsimont D, Awada A, Piccart-Gebhart M
Bull Cancer 2018 Sep;105(9):842-846. Epub 2018 Jul 26 doi: 10.1016/j.bulcan.2018.06.007. PMID: 30057027
Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790
KIT-positive primary small cell carcinoma of the endometrium: a case report with immunohistochemical and molecular genetic analysis of KIT and PDGFRA genes.
Terada T
Arch Gynecol Obstet 2010 Oct;282(4):413-6. Epub 2009 Dec 25 doi: 10.1007/s00404-009-1324-5. PMID: 20035340
Tongue base metastasis from neuroendocrine endometrial small cell carcinoma.
Marioni G, Savastano M, Mattiello L, Koussis H, Carpenè S, Marino F, Staffieri A
Am J Otolaryngol 2007 Jul-Aug;28(4):284-7. doi: 10.1016/j.amjoto.2006.09.011. PMID: 17606050
Exfoliative cytology of neuroendocrine small cell carcinoma of the endometrium. A report of two cases.
Proca D, Keyhani-Rofagha S, Copeland LJ, Hameed A
Acta Cytol 1998 Jul-Aug;42(4):978-82. doi: 10.1159/000331980. PMID: 9684589

Clinical prediction guides

Small cell neuroendocrine carcinoma of the endometrium: a clinicopathologic study of six cases.
Koo YJ, Kim DY, Kim KR, Kim JH, Kim YM, Kim YT, Nam JH
Taiwan J Obstet Gynecol 2014 Sep;53(3):355-9. doi: 10.1016/j.tjog.2013.05.006. PMID: 25286790

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