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Cervical non-keratinizing squamous cell carcinoma

MedGen UID:
309426
•Concept ID:
C1518366
•
Neoplastic Process
Synonyms: Cervical Non-Keratinizing Squamous Cell Carcinoma; cervical non-keratinizing squamous cell carcinoma
 
Monarch Initiative: MONDO:0004413

Definition

A variant of cervical squamous cell carcinoma characterized by the presence of polygonal squamous cells. Intercellular bridges and cytoplasmic keratinization may be present, but keratin pearls are absent. [from NCI]

Professional guidelines

PubMed

Cystic form of cervical lymphadenopathy in adults. Guidelines of the French Society of Otorhinolaryngology (short version). Part 2-etiological diagnosis procedure: Clinical and imaging assessment.
Santini L, Favier V, Benoudiba F, Garcia G, Abgral R, Zerdoud S, Russ G, Bozec A, Tronche S, Pondaven S, Garrel R, de Monès E
Eur Ann Otorhinolaryngol Head Neck Dis 2020 Mar;137(2):117-121. Epub 2020 Feb 26 doi: 10.1016/j.anorl.2019.11.003. PMID: 32114087
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782

Recent clinical studies

Etiology

Comprehensive single-cell transcriptomic and proteomic analysis reveals NK cell exhaustion and unique tumor cell evolutionary trajectory in non-keratinizing nasopharyngeal carcinoma.
Chen C, Wang C, Pang R, Liu H, Yin W, Chen J, Tao L
J Transl Med 2023 Apr 25;21(1):278. doi: 10.1186/s12967-023-04112-8. PMID: 37098551Free PMC Article
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Infectious Agents Associated with Head and Neck Carcinomas.
Hettmann A, Demcsák A, Decsi G, Bach Á, Pálinkó D, Rovó L, Nagy K, Takács M, Minarovits J
Adv Exp Med Biol 2016;897:63-80. doi: 10.1007/5584_2015_5005. PMID: 26563307
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Diagnosis

Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Therapy

A Novel Prognostic Risk Model for Cervical Cancer Based on Immune Checkpoint HLA-G-Driven Differentially Expressed Genes.
Xu HH, Wang HL, Xing TJ, Wang XQ
Front Immunol 2022;13:851622. Epub 2022 Jul 18 doi: 10.3389/fimmu.2022.851622. PMID: 35924232Free PMC Article
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article
Improved response and survival to combined cisplatin and radiation in non-keratinizing squamous cell carcinomas of the head and neck. An RTOG study of 114 advanced stage tumors.
Crissman JD, Pajak TF, Zarbo RJ, Marcial VA, Al-Sarraf M
Cancer 1987 Apr 15;59(8):1391-7. doi: 10.1002/1097-0142(19870415)59:8<1391::aid-cncr2820590802>3.0.co;2-m. PMID: 2434208

Prognosis

Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Nasopharyngeal carcinoma.
Brennan B
Orphanet J Rare Dis 2006 Jun 26;1:23. doi: 10.1186/1750-1172-1-23. PMID: 16800883Free PMC Article

Clinical prediction guides

Human papillomavirus-related neoplasia of the ocular adnexa.
Ramberg IMS
Acta Ophthalmol 2022 Oct;100 Suppl 272(Suppl 272):3-33. doi: 10.1111/aos.15244. PMID: 36203222Free PMC Article
Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma.
Prieto-Granada CN, Xu B, Alzumaili B, Al Rasheed MRH, Eskander A, Enepekides D, Patel SG, Stevens TM, Dogan S, Ghossein R, Katabi N
Virchows Arch 2021 Oct;479(4):729-739. Epub 2021 May 12 doi: 10.1007/s00428-021-03117-2. PMID: 33982148Free PMC Article
Human Papillomavirus-Related Neuroendocrine Carcinomas of the Head and Neck.
Westra WH
Head Neck Pathol 2018 Mar;12(1):9-12. Epub 2018 Mar 20 doi: 10.1007/s12105-018-0886-6. PMID: 29556964Free PMC Article
HPV-related squamous cell carcinoma of the head and neck: An update on testing in routine pathology practice.
Bishop JA, Lewis JS Jr, Rocco JW, Faquin WC
Semin Diagn Pathol 2015 Sep;32(5):344-51. Epub 2015 Feb 4 doi: 10.1053/j.semdp.2015.02.013. PMID: 25724476
Cytologic evaluation of cervical lymph node metastases from cancers of unknown primary origin.
Pusztaszeri MP, Faquin WC
Semin Diagn Pathol 2015 Jan;32(1):32-41. Epub 2014 Dec 20 doi: 10.1053/j.semdp.2014.12.002. PMID: 25618223

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