U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Colon Intramucosal Adenocarcinoma

MedGen UID:
310620
•Concept ID:
C1707434
•
Neoplastic Process
Synonym: Colon Intramucosal Neoplasia

Definition

An adenocarcinoma that arises from the colonic glandular epithelium and invades the lamina propria or muscularis mucosa but not the submucosa. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Intramucosal Adenocarcinoma

Professional guidelines

PubMed

Warning for unprincipled colorectal endoscopic submucosal dissection: accurate diagnosis and reasonable treatment strategy.
Tanaka S, Terasaki M, Hayashi N, Oka S, Chayama K
Dig Endosc 2013 Mar;25(2):107-16. Epub 2012 Dec 20 doi: 10.1111/den.12016. PMID: 23368854Free PMC Article
Utility of MMP-1, p53, E-cadherin, and collagen IV immunohistochemical stains in the differential diagnosis of adenomas with misplaced epithelium versus adenomas with invasive adenocarcinoma.
Yantiss RK, Bosenberg MW, Antonioli DA, Odze RD
Am J Surg Pathol 2002 Feb;26(2):206-15. doi: 10.1097/00000478-200202000-00007. PMID: 11812942

Recent clinical studies

Etiology

EMR/ESD: Techniques, Complications, and Evidence.
Ahmed Y, Othman M
Curr Gastroenterol Rep 2020 Jun 15;22(8):39. doi: 10.1007/s11894-020-00777-z. PMID: 32542462
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153
Endoscopic mucosal imaging of gastrointestinal neoplasia in 2013.
Urquhart P, DaCosta R, Marcon N
Curr Gastroenterol Rep 2013 Jul;15(7):330. doi: 10.1007/s11894-013-0330-8. PMID: 23771504
Barrett's oesophagus: an ideal model to study cancer genetics.
di Pietro M, Fitzgerald RC
Hum Genet 2009 Aug;126(2):233-46. Epub 2009 Apr 14 doi: 10.1007/s00439-009-0665-2. PMID: 19365640

Diagnosis

Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies.
Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM
J Clin Pathol 2022 Sep;75(9):593-597. Epub 2021 Apr 12 doi: 10.1136/jclinpath-2021-207406. PMID: 33846218
Colonic Adenomatous Polyps Involving Submucosal Lymphoglandular Complexes: A Diagnostic Pitfall.
Lee HE, Wu TT, Chandan VS, Torbenson MS, Mounajjed T
Am J Surg Pathol 2018 Aug;42(8):1083-1089. doi: 10.1097/PAS.0000000000001081. PMID: 29738362
Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.
Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A
Hum Pathol 2017 Aug;66:230-237. Epub 2017 Jul 13 doi: 10.1016/j.humpath.2017.04.031. PMID: 28711649
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Endoscopic mucosal imaging of gastrointestinal neoplasia in 2013.
Urquhart P, DaCosta R, Marcon N
Curr Gastroenterol Rep 2013 Jul;15(7):330. doi: 10.1007/s11894-013-0330-8. PMID: 23771504

Therapy

Pazopanib-induced enteritis in a patient with renal cell carcinoma.
Ariyoshi M, Hayashi R, Takasago T, Yamashita K, Hiyama Y, Yuge R, Urabe Y, Ueno Y, Shimamoto F, Oka S
Clin J Gastroenterol 2024 Jun;17(3):434-440. Epub 2024 Feb 26 doi: 10.1007/s12328-024-01919-w. PMID: 38407743
EMR combined with hybrid argon plasma coagulation to prevent recurrence of large nonpedunculated colorectal polyps (with videos).
Motchum L, Levenick JM, Djinbachian R, Moyer MT, Bouchard S, Taghiakbari M, Repici A, Deslandres É, von Renteln D
Gastrointest Endosc 2022 Nov;96(5):840-848.e2. Epub 2022 Jun 18 doi: 10.1016/j.gie.2022.06.018. PMID: 35724695
Mesenteric phlebosclerosis complicating colonic cancer treated by endoscopic submucosal dissection.
Kawasaki K, Eizuka M, Kudara N, Yanai S, Toya Y, Torisu T, Umeno J, Nakamura S, Sugai T, Matsumoto T
Clin J Gastroenterol 2020 Dec;13(6):1183-1188. Epub 2020 Aug 16 doi: 10.1007/s12328-020-01205-5. PMID: 32803642
EMR/ESD: Techniques, Complications, and Evidence.
Ahmed Y, Othman M
Curr Gastroenterol Rep 2020 Jun 15;22(8):39. doi: 10.1007/s11894-020-00777-z. PMID: 32542462
Endoscopic mucosal imaging of gastrointestinal neoplasia in 2013.
Urquhart P, DaCosta R, Marcon N
Curr Gastroenterol Rep 2013 Jul;15(7):330. doi: 10.1007/s11894-013-0330-8. PMID: 23771504

Prognosis

Colonic Adenomatous Polyps Involving Submucosal Lymphoglandular Complexes: A Diagnostic Pitfall.
Lee HE, Wu TT, Chandan VS, Torbenson MS, Mounajjed T
Am J Surg Pathol 2018 Aug;42(8):1083-1089. doi: 10.1097/PAS.0000000000001081. PMID: 29738362
Gastrointestinal Polyposis in Cowden Syndrome.
Shaco-Levy R, Jasperson KW, Martin K, Samadder NJ, Burt RW, Ying J, Bronner MP
J Clin Gastroenterol 2017 Aug;51(7):e60-e67. doi: 10.1097/MCG.0000000000000703. PMID: 27661969
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153
Barrett's oesophagus: an ideal model to study cancer genetics.
di Pietro M, Fitzgerald RC
Hum Genet 2009 Aug;126(2):233-46. Epub 2009 Apr 14 doi: 10.1007/s00439-009-0665-2. PMID: 19365640
Pathology of colorectal cancer.
Ponz de Leon M, Di Gregorio C
Dig Liver Dis 2001 May;33(4):372-88. doi: 10.1016/s1590-8658(01)80095-5. PMID: 11432519

Clinical prediction guides

WHICH LESIONS ARE AT HIGHER RISK OF DEVELOPING COLORECTAL CARCINOMAS: SUPERFICIALLY ELEVATED SERRATED LESIONS OR DEPRESSED LESIONS?
Parada AA, Venco FE, Varca-Neto MR, El Ibrahim R, Poletti PB, Brito HP, Sare HF, Malafaia O
Arq Bras Cir Dig 2023;35:e1716. Epub 2023 Jan 9 doi: 10.1590/0102-672020220002e1716. PMID: 36629693Free PMC Article
Invasive carcinoma versus pseudoinvasion: interobserver variability in the assessment of left-sided colorectal polypectomies.
Lee M, Kudose S, Del Portillo A, Ko HM, Lee H, Pittman ME, Salomao MA, Sepulveda AR, Lagana SM
J Clin Pathol 2022 Sep;75(9):593-597. Epub 2021 Apr 12 doi: 10.1136/jclinpath-2021-207406. PMID: 33846218
Colonic Adenomatous Polyps Involving Submucosal Lymphoglandular Complexes: A Diagnostic Pitfall.
Lee HE, Wu TT, Chandan VS, Torbenson MS, Mounajjed T
Am J Surg Pathol 2018 Aug;42(8):1083-1089. doi: 10.1097/PAS.0000000000001081. PMID: 29738362
Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.
Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A
Hum Pathol 2017 Aug;66:230-237. Epub 2017 Jul 13 doi: 10.1016/j.humpath.2017.04.031. PMID: 28711649
Development and progression of colorectal cancer based on follow-up analysis.
Hisabe T, Hirai F, Matsui T
Dig Endosc 2014 Apr;26 Suppl 2:73-7. doi: 10.1111/den.12276. PMID: 24750153

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...