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Corneal Sensitivity

MedGen UID:
310639
•Concept ID:
C1707516
•
Sign or Symptom

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCorneal Sensitivity

Professional guidelines

PubMed

Expert consensus on the identification, diagnosis, and treatment of neurotrophic keratopathy.
Dana R, Farid M, Gupta PK, Hamrah P, Karpecki P, McCabe CM, Nijm L, Pepose JS, Pflugfelder S, Rapuano CJ, Saini A, Gibbs SN, Broder MS
BMC Ophthalmol 2021 Sep 8;21(1):327. doi: 10.1186/s12886-021-02092-1. PMID: 34493256Free PMC Article
Cenegermin for the treatment of neurotrophic keratitis.
Sacchetti M, Bruscolini A, Lambiase A
Drugs Today (Barc) 2017 Nov;53(11):585-595. doi: 10.1358/dot.2017.53.11.2722395. PMID: 29451275
Congenital Corneal Anesthesia and Neurotrophic Keratitis: Diagnosis and Management.
Mantelli F, Nardella C, Tiberi E, Sacchetti M, Bruscolini A, Lambiase A
Biomed Res Int 2015;2015:805876. Epub 2015 Sep 16 doi: 10.1155/2015/805876. PMID: 26451380Free PMC Article

Recent clinical studies

Etiology

Age-Related Changes in Corneal Sensitivity.
Nosch DS, Käser E, Bracher T, Joos RE
Cornea 2023 Oct 1;42(10):1257-1262. Epub 2022 Nov 21 doi: 10.1097/ICO.0000000000003183. PMID: 36730377
Ocular manifestations of congenital insensitivity to pain: a long-term follow-up.
Elsana B, Gradstein L, Imtirat A, Yagev R, Barrett C, Ling G, Abu Tailakh M, Baidousi A, Tsumi E
Br J Ophthalmol 2022 Sep;106(9):1217-1221. Epub 2021 Mar 22 doi: 10.1136/bjophthalmol-2020-317464. PMID: 33753408
Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome.
Kang EY, Chen HT, Hsueh YJ, Chen HC, Tan HY, Hsiao CH, Yeh LK, Wu WC
Invest Ophthalmol Vis Sci 2020 Mar 9;61(3):21. doi: 10.1167/iovs.61.3.21. PMID: 32181797Free PMC Article
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Eye and pregnancy.
Gotovac M, Kastelan S, Lukenda A
Coll Antropol 2013 Apr;37 Suppl 1:189-93. PMID: 23837242

Diagnosis

Comparison of clinical outcomes of LASIK, Trans-PRK, and SMILE for correction of myopia.
Chang JY, Lin PY, Hsu CC, Liu CJ
J Chin Med Assoc 2022 Feb 1;85(2):145-151. doi: 10.1097/JCMA.0000000000000674. PMID: 34861667
Dry Eyes After SMILE.
Wong AHY, Cheung RKY, Kua WN, Shih KC, Chan TCY, Wan KH
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):397-405. doi: 10.1097/01.APO.0000580136.80338.d0. PMID: 31490199Free PMC Article
Neurotrophic keratitis.
Semeraro F, Forbice E, Romano V, Angi M, Romano MR, Filippelli ME, Di Iorio R, Costagliola C
Ophthalmologica 2014;231(4):191-7. Epub 2013 Oct 2 doi: 10.1159/000354380. PMID: 24107451
Neurotrophic keratitis.
Bonini S, Rama P, Olzi D, Lambiase A
Eye (Lond) 2003 Nov;17(8):989-95. doi: 10.1038/sj.eye.6700616. PMID: 14631406
Corneal hypoesthesia.
Martin XY, Safran AB
Surv Ophthalmol 1988 Jul-Aug;33(1):28-40. doi: 10.1016/0039-6257(88)90070-7. PMID: 3051467

Therapy

Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Dry Eyes After SMILE.
Wong AHY, Cheung RKY, Kua WN, Shih KC, Chan TCY, Wan KH
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct;8(5):397-405. doi: 10.1097/01.APO.0000580136.80338.d0. PMID: 31490199Free PMC Article
Dry Eye After LASIK.
Toda I
Invest Ophthalmol Vis Sci 2018 Nov 1;59(14):DES109-DES115. doi: 10.1167/iovs.17-23538. PMID: 30481814
Cenegermin for the treatment of neurotrophic keratitis.
Sacchetti M, Bruscolini A, Lambiase A
Drugs Today (Barc) 2017 Nov;53(11):585-595. doi: 10.1358/dot.2017.53.11.2722395. PMID: 29451275
Eye and pregnancy.
Gotovac M, Kastelan S, Lukenda A
Coll Antropol 2013 Apr;37 Suppl 1:189-93. PMID: 23837242

Prognosis

Comparison of clinical outcomes of LASIK, Trans-PRK, and SMILE for correction of myopia.
Chang JY, Lin PY, Hsu CC, Liu CJ
J Chin Med Assoc 2022 Feb 1;85(2):145-151. doi: 10.1097/JCMA.0000000000000674. PMID: 34861667
Ocular manifestations of congenital insensitivity to pain: a long-term follow-up.
Elsana B, Gradstein L, Imtirat A, Yagev R, Barrett C, Ling G, Abu Tailakh M, Baidousi A, Tsumi E
Br J Ophthalmol 2022 Sep;106(9):1217-1221. Epub 2021 Mar 22 doi: 10.1136/bjophthalmol-2020-317464. PMID: 33753408
Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome.
Kang EY, Chen HT, Hsueh YJ, Chen HC, Tan HY, Hsiao CH, Yeh LK, Wu WC
Invest Ophthalmol Vis Sci 2020 Mar 9;61(3):21. doi: 10.1167/iovs.61.3.21. PMID: 32181797Free PMC Article
Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R
Ophthalmology 2020 Jan;127(1):14-26. Epub 2019 Aug 26 doi: 10.1016/j.ophtha.2019.08.020. PMID: 31585826
Neurotrophic keratitis.
Bonini S, Rama P, Olzi D, Lambiase A
Eye (Lond) 2003 Nov;17(8):989-95. doi: 10.1038/sj.eye.6700616. PMID: 14631406

Clinical prediction guides

Age-Related Changes in Corneal Sensitivity.
Nosch DS, Käser E, Bracher T, Joos RE
Cornea 2023 Oct 1;42(10):1257-1262. Epub 2022 Nov 21 doi: 10.1097/ICO.0000000000003183. PMID: 36730377
Comparison of clinical outcomes of LASIK, Trans-PRK, and SMILE for correction of myopia.
Chang JY, Lin PY, Hsu CC, Liu CJ
J Chin Med Assoc 2022 Feb 1;85(2):145-151. doi: 10.1097/JCMA.0000000000000674. PMID: 34861667
Fibromyalgia syndrome and the eye-A review.
Zdebik N, Zdebik A, Bogusławska J, Przeździecka-Dołyk J, Turno-Kręcicka A
Surv Ophthalmol 2021 Jan-Feb;66(1):132-137. Epub 2020 Jun 5 doi: 10.1016/j.survophthal.2020.05.006. PMID: 32512032
Corneal Sensitivity and Tear Function in Recurrent Corneal Erosion Syndrome.
Kang EY, Chen HT, Hsueh YJ, Chen HC, Tan HY, Hsiao CH, Yeh LK, Wu WC
Invest Ophthalmol Vis Sci 2020 Mar 9;61(3):21. doi: 10.1167/iovs.61.3.21. PMID: 32181797Free PMC Article
Corneal Sensitivity as a Potential Marker of Diabetic Neuropathy.
Sitompul R
Acta Med Indones 2017 Apr;49(2):166-172. PMID: 28790232

Recent systematic reviews

TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface.
Galor A, Britten-Jones AC, Feng Y, Ferrari G, Goldblum D, Gupta PK, Merayo-Lloves J, Na KS, Naroo SA, Nichols KK, Rocha EM, Tong L, Wang MTM, Craig JP
Ocul Surf 2023 Apr;28:262-303. Epub 2023 Apr 11 doi: 10.1016/j.jtos.2023.04.008. PMID: 37054911
Structural changes associated to orthokeratology: A systematic review.
Sánchez-García A, Ariza MA, Büchler P, Molina-Martin A, Piñero DP
Cont Lens Anterior Eye 2021 Aug;44(4):101371. Epub 2020 Oct 10 doi: 10.1016/j.clae.2020.10.001. PMID: 33051140
Biomarkers in Tears and Ocular Surface: A Window for Neurodegenerative Diseases.
Roda M, Ciavarella C, Giannaccare G, Versura P
Eye Contact Lens 2020 Mar;46 Suppl 2:S129-S134. doi: 10.1097/ICL.0000000000000663. PMID: 31658175
Small Incision Lenticule Extraction (SMILE) versus Femtosecond Laser-Assisted In Situ Keratomileusis (FS-LASIK) for Myopia: A Systematic Review and Meta-Analysis.
Shen Z, Shi K, Yu Y, Yu X, Lin Y, Yao K
PLoS One 2016;11(7):e0158176. Epub 2016 Jul 1 doi: 10.1371/journal.pone.0158176. PMID: 27367803Free PMC Article
Clinical Outcomes of SMILE and FS-LASIK Used to Treat Myopia: A Meta-analysis.
Zhang Y, Shen Q, Jia Y, Zhou D, Zhou J
J Refract Surg 2016 Apr;32(4):256-65. doi: 10.3928/1081597X-20151111-06. PMID: 27070233

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