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Gallbladder Adenocarcinoma, Intestinal-Type

MedGen UID:
310795
•Concept ID:
C1708171
•
Neoplastic Process

Definition

An adenocarcinoma that arises from the gallbladder. It is characterized by the presence of neoplastic tubular glands lined by columnar cells or neoplastic glands lined by goblet cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Adenocarcinoma, Intestinal-Type

Recent clinical studies

Etiology

Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2.
McCluggage WG, Shah R, Connolly LE, McBride HA
Int J Gynecol Pathol 2008 Jan;27(1):92-100. doi: 10.1097/pgp.0b013e31815698e7. PMID: 18156982
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813

Diagnosis

Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review.
Sasatomi E, Nalesnik MA, Marsh JW
World J Gastroenterol 2013 Jul 28;19(28):4616-23. doi: 10.3748/wjg.v19.i28.4616. PMID: 23901240Free PMC Article
Intestinal-type cervical adenocarcinoma in situ and adenocarcinoma exhibit a partial enteric immunophenotype with consistent expression of CDX2.
McCluggage WG, Shah R, Connolly LE, McBride HA
Int J Gynecol Pathol 2008 Jan;27(1):92-100. doi: 10.1097/pgp.0b013e31815698e7. PMID: 18156982
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428
p53 and Ki-67 immunoreactivity and nuclear morphometry of 'carcinoma-in-adenoma' and adenoma of the gall-bladder.
Takei K, Watanabe H, Itoi T, Saito T
Pathol Int 1996 Nov;46(11):908-17. doi: 10.1111/j.1440-1827.1996.tb03569.x. PMID: 8970203

Prognosis

Cystadenomas of the liver and extrahepatic bile ducts: Morphologic and immunohistochemical characterization of the biliary and intestinal variants.
Albores-Saavedra J, Córdova-Ramón JC, Chablé-Montero F, Dorantes-Heredia R, Henson DE
Ann Diagn Pathol 2015 Jun;19(3):124-9. Epub 2015 Mar 6 doi: 10.1016/j.anndiagpath.2015.03.001. PMID: 25792461
Pathogenesis of carcinoma of the papilla of Vater.
Fischer HP, Zhou H
J Hepatobiliary Pancreat Surg 2004;11(5):301-9. doi: 10.1007/s00534-004-0898-3. PMID: 15549428
The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas.
Kaimaktchiev V, Terracciano L, Tornillo L, Spichtin H, Stoios D, Bundi M, Korcheva V, Mirlacher M, Loda M, Sauter G, Corless CL
Mod Pathol 2004 Nov;17(11):1392-9. doi: 10.1038/modpathol.3800205. PMID: 15205684
Mutation and altered expression of beta-catenin during gallbladder carcinogenesis.
Chang HJ, Jee CD, Kim WH
Am J Surg Pathol 2002 Jun;26(6):758-66. doi: 10.1097/00000478-200206000-00009. PMID: 12023580
Carcinoma of the gallbladder: the correlation between histogenesis and prognosis.
Yamamoto M, Nakajo S, Tahara E
Virchows Arch A Pathol Anat Histopathol 1989;414(2):83-90. doi: 10.1007/BF00718587. PMID: 2492696

Clinical prediction guides

The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas.
Kaimaktchiev V, Terracciano L, Tornillo L, Spichtin H, Stoios D, Bundi M, Korcheva V, Mirlacher M, Loda M, Sauter G, Corless CL
Mod Pathol 2004 Nov;17(11):1392-9. doi: 10.1038/modpathol.3800205. PMID: 15205684
Intestinal type cholangiocarcinoma of intrahepatic large bile duct associated with hepatolithiasis--a new histologic subtype for further investigation.
Bae JY, Park YN, Nakanuma Y, Lee WJ, Kim JY, Park C
Hepatogastroenterology 2002 May-Jun;49(45):628-30. PMID: 12063956
p53 and Ki-67 immunoreactivity and nuclear morphometry of 'carcinoma-in-adenoma' and adenoma of the gall-bladder.
Takei K, Watanabe H, Itoi T, Saito T
Pathol Int 1996 Nov;46(11):908-17. doi: 10.1111/j.1440-1827.1996.tb03569.x. PMID: 8970203
p53 and Ki-67 immunoreactivity and nuclear morphometry of 'carcinoma-in-adenoma' and adenoma of the gall-bladder.
Takei K, Watanabe H, Itoi T, Saito T
Pathol Int 1996 Jun;46(6):426-35. doi: 10.1111/j.1440-1827.1996.tb03633.x. PMID: 8869994
Inappropriate mucin production in gall bladder metaplasia and neoplasia--an immunohistological study.
De Boer WG, Ma J, Rees JW, Nayman J
Histopathology 1981 May;5(3):295-303. doi: 10.1111/j.1365-2559.1981.tb01788.x. PMID: 7239450

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