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Laryngeal Squamous Cell Carcinoma, Spindle Cell Variant

MedGen UID:
310918
•Concept ID:
C1708656
•
Neoplastic Process
Synonyms: Laryngeal Carcinosarcoma; Laryngeal Sarcomatoid Carcinoma

Definition

A carcinoma that arises from the larynx and is characterized by the presence of a malignant spindle cell cellular component and a squamous cell carcinoma component. The latter is either in situ or invasive squamous cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Squamous Cell Carcinoma, Spindle Cell Variant

Professional guidelines

PubMed

Basaloid squamous cell carcinoma of the head and neck: clinicopathological features and differential diagnosis.
Barnes L, Ferlito A, Altavilla G, MacMillan C, Rinaldo A, Doglioni C
Ann Otol Rhinol Laryngol 1996 Jan;105(1):75-82. doi: 10.1177/000348949610500115. PMID: 8546432
Head and neck spindle cell carcinoma: an evaluation of current management.
Benninger MS, Kraus D, Sebek B, Tucker HM, Lavertu P
Cleve Clin J Med 1992 Sep-Oct;59(5):479-82. doi: 10.3949/ccjm.59.5.479. PMID: 1281758

Recent clinical studies

Etiology

Spindle Cell Carcinoma of the Head and Neck: Clinical Characteristics and Molecular Signatures.
Lin MC, Hsu CL, Lai SF, Huang YL, Hsieh MS, Chen TC, Chen CN, Wang CP, Yang TL, Ko JY, Tsai MH, Lou PJ
Laryngoscope 2023 Sep;133(9):2183-2191. Epub 2022 Oct 27 doi: 10.1002/lary.30467. PMID: 36300609
Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
de Araújo AB, Serrano TLI, Pedroso MCM, Mariano FV, Altemani A, Gripp FM, Crespo AN, Chone CT
Pathol Oncol Res 2020 Apr;26(2):1097-1104. Epub 2019 May 9 doi: 10.1007/s12253-019-00654-9. PMID: 31069711
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Diagnosis

Spindle Cell Carcinoma of the Head and Neck: Clinical Characteristics and Molecular Signatures.
Lin MC, Hsu CL, Lai SF, Huang YL, Hsieh MS, Chen TC, Chen CN, Wang CP, Yang TL, Ko JY, Tsai MH, Lou PJ
Laryngoscope 2023 Sep;133(9):2183-2191. Epub 2022 Oct 27 doi: 10.1002/lary.30467. PMID: 36300609
Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
Thompson LD
Surg Pathol Clin 2017 Mar;10(1):15-33. doi: 10.1016/j.path.2016.10.003. PMID: 28153131
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Therapy

Tracheal Rupture After Tracheostomy Tube Exchange in a Patient With Recurrent Oral Cavity Spindle Cell Carcinoma.
Raskin J, Borrelli M, Nasrollahi T, Heaton C
Ear Nose Throat J 2022 Dec;101(10_suppl):15S-18S. Epub 2022 Aug 26 doi: 10.1177/01455613221123854. PMID: 36017599
Sarcomatoid carcinoma after radiotherapy for early-stage oral squamous cell carcinoma: Case report.
Kim BY, Cho KR, Sohn JH, Kim JY
Medicine (Baltimore) 2019 Jul;98(27):e16003. doi: 10.1097/MD.0000000000016003. PMID: 31277093Free PMC Article
Prolonged Response to Pembrolizumab in Spindle Cell Squamous Cell Carcinoma Metastatic to the Central Nervous System.
Liu Y, Fitzgerald B, Perry E, Pathak A, Chao HH
J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619850216. doi: 10.1177/2324709619850216. PMID: 31132886Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Laryngeal pseudosarcoma.
Giordano AM, Ewing S, Adams G, Maisel R
Laryngoscope 1983 Jun;93(6):735-40. doi: 10.1288/00005537-198306000-00007. PMID: 6855396

Prognosis

Distant metastasis in head and neck squamous cell carcinoma variants: A population-based study.
Takenaka Y, Uno A, Tanaka H, Takemoto N, Inohara H
Head Neck 2023 Apr;45(4):882-889. Epub 2023 Feb 21 doi: 10.1002/hed.27305. PMID: 36811303
Spindle Cell Carcinoma of the Head and Neck: Clinical Characteristics and Molecular Signatures.
Lin MC, Hsu CL, Lai SF, Huang YL, Hsieh MS, Chen TC, Chen CN, Wang CP, Yang TL, Ko JY, Tsai MH, Lou PJ
Laryngoscope 2023 Sep;133(9):2183-2191. Epub 2022 Oct 27 doi: 10.1002/lary.30467. PMID: 36300609
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Laryngeal pseudosarcoma.
Giordano AM, Ewing S, Adams G, Maisel R
Laryngoscope 1983 Jun;93(6):735-40. doi: 10.1288/00005537-198306000-00007. PMID: 6855396

Clinical prediction guides

Spindle Cell Carcinoma of the Head and Neck: Clinical Characteristics and Molecular Signatures.
Lin MC, Hsu CL, Lai SF, Huang YL, Hsieh MS, Chen TC, Chen CN, Wang CP, Yang TL, Ko JY, Tsai MH, Lou PJ
Laryngoscope 2023 Sep;133(9):2183-2191. Epub 2022 Oct 27 doi: 10.1002/lary.30467. PMID: 36300609
Non-Squamous Cell Malignancies of the Larynx.
Rotsides JM, Patel E, Oliver JR, Moses LE, Jacobson AS, Hu KS, Vaezi A, Tam M, Givi B
Laryngoscope 2022 Sep;132(9):1771-1777. Epub 2022 Jan 7 doi: 10.1002/lary.30007. PMID: 34994977
Association between sex and survival in patients with head and neck spindle cell carcinoma.
Hennocq Q, Saintigny P, Quilhot P, Bertolus C, Foy JP
Head Neck 2021 Jun;43(6):1864-1871. Epub 2021 Feb 24 doi: 10.1002/hed.26656. PMID: 33629469
Clinicopathologic Diagnostic and Prognostic Factors of Spindle Cell Carcinoma of Upper Airway.
de Araújo AB, Serrano TLI, Pedroso MCM, Mariano FV, Altemani A, Gripp FM, Crespo AN, Chone CT
Pathol Oncol Res 2020 Apr;26(2):1097-1104. Epub 2019 May 9 doi: 10.1007/s12253-019-00654-9. PMID: 31069711
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

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