U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lung Spindle Cell Carcinoma

MedGen UID:
310951
•Concept ID:
C1708784
•
Neoplastic Process
Synonym: Spindle cell carcinoma of lung
SNOMED CT: Spindle cell carcinoma of lung (1255395009)

Definition

A morphologic variant of sarcomatoid carcinoma characterized by the presence of malignant spindle cells and focal lymphoplasmacytic infiltrates. Adenocarcinoma cells, malignant squamous cells, and giant cells are not present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Spindle Cell Carcinoma

Professional guidelines

PubMed

Non-oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Hendriks LE, Kerr KM, Menis J, Mok TS, Nestle U, Passaro A, Peters S, Planchard D, Smit EF, Solomon BJ, Veronesi G, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Apr;34(4):358-376. Epub 2023 Jan 17 doi: 10.1016/j.annonc.2022.12.013. PMID: 36669645
SCLC: Epidemiology, Risk Factors, Genetic Susceptibility, Molecular Pathology, Screening, and Early Detection.
Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387Free PMC Article
Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment.
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236

Recent clinical studies

Etiology

Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma (PSCC): a population-based retrospective study.
Zhang J, Yan Y, Hui B, Bai S, Ma W, Ren J
Ann Palliat Med 2021 Apr;10(4):3793-3803. Epub 2021 Mar 8 doi: 10.21037/apm-20-1841. PMID: 33691442

Diagnosis

Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.
Mizushina Y, Ohyanagi F, Shiihara J, Nomura M, Ohta H, Oshiro H, Tsubochi H, Kusaka G, Yamaguchi Y
Thorac Cancer 2021 Aug;12(16):2279-2282. Epub 2021 Jul 5 doi: 10.1111/1759-7714.14068. PMID: 34227241Free PMC Article

Therapy

TIM-3 expression induces resistance to PD-1 inhibitor in G-CSF-producing lung spindle cell carcinoma: A case report.
Hayashi F, Akagi K, Taniguchi H, Matsutake T, Kawahara H, Sekine I, Gyotoku H, Takemoto S, Soda H, Ashizawa K, Mukae H
Thorac Cancer 2023 Dec;14(36):3556-3560. Epub 2023 Nov 5 doi: 10.1111/1759-7714.15149. PMID: 37926435Free PMC Article
Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.
Mizushina Y, Ohyanagi F, Shiihara J, Nomura M, Ohta H, Oshiro H, Tsubochi H, Kusaka G, Yamaguchi Y
Thorac Cancer 2021 Aug;12(16):2279-2282. Epub 2021 Jul 5 doi: 10.1111/1759-7714.14068. PMID: 34227241Free PMC Article

Prognosis

Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma (PSCC): a population-based retrospective study.
Zhang J, Yan Y, Hui B, Bai S, Ma W, Ren J
Ann Palliat Med 2021 Apr;10(4):3793-3803. Epub 2021 Mar 8 doi: 10.21037/apm-20-1841. PMID: 33691442

Clinical prediction guides

Clinical case of lung spindle cell carcinoma markedly responsive to pembrolizumab.
Mizushina Y, Ohyanagi F, Shiihara J, Nomura M, Ohta H, Oshiro H, Tsubochi H, Kusaka G, Yamaguchi Y
Thorac Cancer 2021 Aug;12(16):2279-2282. Epub 2021 Jul 5 doi: 10.1111/1759-7714.14068. PMID: 34227241Free PMC Article
Clinicopathological characteristics and prognosis of pulmonary spindle cell carcinoma (PSCC): a population-based retrospective study.
Zhang J, Yan Y, Hui B, Bai S, Ma W, Ren J
Ann Palliat Med 2021 Apr;10(4):3793-3803. Epub 2021 Mar 8 doi: 10.21037/apm-20-1841. PMID: 33691442

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...