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Vaginal Keratinizing Squamous Cell Carcinoma

MedGen UID:
311445
•Concept ID:
C1519922
•
Neoplastic Process

Definition

A squamous cell carcinoma that arises from the vagina and is characterized by the presence of keratin pearls. Intercellular bridges and cytoplasmic keratinization are usually present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal Keratinizing Squamous Cell Carcinoma

Professional guidelines

PubMed

AgNOR technique could be useful for differential diagnosis of squamous carcinomatous cells and atypical cells related to human papillomavirus in cervical smears.
Palaoro L, Rocher A
Biotech Histochem 2009 Jun;84(3):73-8. Epub 2009 Mar 28 doi: 10.1080/10520290902853412. PMID: 19333799
Carcinoma of the cervix stage IB: results of treatment with radiation therapy.
Montana GS, Fowler WC Jr, Varia MA, Walton LA, Kirsch M, Halle JS, McCafferty BB
Int J Radiat Oncol Biol Phys 1983 Jan;9(1):45-9. doi: 10.1016/0360-3016(83)90207-9. PMID: 6841175
THE DIAGNOSIS AND TREATMENT OF PRIMARY EPIDERMOID CARCINOMA OF THE VAGINA.
CALEEL RT, SHEETS JD
J Am Osteopath Assoc 1964 Oct;64:131-6. PMID: 14216387

Recent clinical studies

Etiology

Multimodality imaging of diseases of the vagina.
Pulappadi VP, Manchanda S, Dhamija E, Jana M
Br J Radiol 2024 Feb 28;97(1155):513-525. doi: 10.1093/bjr/tqad052. PMID: 38419147
The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS
Int J Gynecol Cancer 2003 Mar-Apr;13(2):103-10. doi: 10.1046/j.1525-1438.2003.13030.x. PMID: 12657108
False-positive squamous cell carcinoma in cervical smears: cytologic-histologic correlation in 19 cases.
Levine PH, Elgert PA, Mittal K
Diagn Cytopathol 2003 Jan;28(1):23-7. doi: 10.1002/dc.10220. PMID: 12508178
Papillomavirus and anal carcinoma.
Poletti PA, Halfon A, Marti MC
Int J Colorectal Dis 1998;13(2):108-11. doi: 10.1007/s003840050145. PMID: 9638498
Chemoprevention trials in the cervix: design, feasibility, and recruitment.
Mitchell MF, Hittelman WN, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Hong WK
J Cell Biochem Suppl 1995;23:104-12. PMID: 8747384

Diagnosis

Epidermoid carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Case report and literature review.
Fernández-Ruiz M, Pantoja-Garrido M, Frías-Sánchez Z, Rodríguez-Jiménez I, Aguilar-Martín MDV
Rev Colomb Obstet Ginecol 2019 Dec;70(4):266-276. doi: 10.18597/rcog.3328. PMID: 32142241
Primary squamous cell carcinoma of the endometrium: a case report.
Bifulco G, Giampaolino P, Mandato VD, Morra I, Nappi C, Insabato L
Eur J Gynaecol Oncol 2011;32(3):350-2. PMID: 21797134
Primary squamous cell carcinoma of the vagina: human papillomavirus detection, p16(INK4A) overexpression and clinicopathological correlations.
Fuste V, del Pino M, Perez A, Garcia A, Torne A, Pahisa J, Ordi J
Histopathology 2010 Dec;57(6):907-16. doi: 10.1111/j.1365-2559.2010.03727.x. PMID: 21166704
False-positive squamous cell carcinoma in cervical smears: cytologic-histologic correlation in 19 cases.
Levine PH, Elgert PA, Mittal K
Diagn Cytopathol 2003 Jan;28(1):23-7. doi: 10.1002/dc.10220. PMID: 12508178
Primary squamous cell carcinoma of the endometrium: case history, pathologic findings, and discussion.
Houissa-Vuong S, Catanzano-Laroudie M, Baviera E, Balaton A, Galet B, Gedeon I, Vuong PN
Diagn Cytopathol 2002 Nov;27(5):291-3. doi: 10.1002/dc.10186. PMID: 12411995

Therapy

The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS
Int J Gynecol Cancer 2003 Mar-Apr;13(2):103-10. doi: 10.1046/j.1525-1438.2003.13030.x. PMID: 12657108
Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.
Arbeit JM, Howley PM, Hanahan D
Proc Natl Acad Sci U S A 1996 Apr 2;93(7):2930-5. doi: 10.1073/pnas.93.7.2930. PMID: 8610145Free PMC Article
Chemoprevention trials in the cervix: design, feasibility, and recruitment.
Mitchell MF, Hittelman WN, Lotan R, Nishioka K, Tortolero-Luna G, Richards-Kortum R, Hong WK
J Cell Biochem Suppl 1995;23:104-12. PMID: 8747384
Carcinoma of the cervix stage IB: results of treatment with radiation therapy.
Montana GS, Fowler WC Jr, Varia MA, Walton LA, Kirsch M, Halle JS, McCafferty BB
Int J Radiat Oncol Biol Phys 1983 Jan;9(1):45-9. doi: 10.1016/0360-3016(83)90207-9. PMID: 6841175
Radiation therapy of primary vaginal carcinoma.
Nori D, Hilaris BS, Stanimir G, Lewis JL Jr
Int J Radiat Oncol Biol Phys 1983 Oct;9(10):1471-5. doi: 10.1016/0360-3016(83)90320-6. PMID: 6629889

Prognosis

Epidermoid carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Case report and literature review.
Fernández-Ruiz M, Pantoja-Garrido M, Frías-Sánchez Z, Rodríguez-Jiménez I, Aguilar-Martín MDV
Rev Colomb Obstet Ginecol 2019 Dec;70(4):266-276. doi: 10.18597/rcog.3328. PMID: 32142241
Does Differentiated Squamous Intraepithelial Neoplasia Occur in the Cervix?
Mai KT
Appl Immunohistochem Mol Morphol 2018 Apr;26(4):e52-e60. doi: 10.1097/PAI.0000000000000577. PMID: 28877072
Primary squamous cell carcinoma of endometrium: clinicopathologic analysis of two cases with review of the literature.
Li Y, Lu HJ, Yang Y
Eur J Gynaecol Oncol 2013;34(4):355-7. PMID: 24020148
Primary squamous cell carcinoma of the endometrium: case history, pathologic findings, and discussion.
Houissa-Vuong S, Catanzano-Laroudie M, Baviera E, Balaton A, Galet B, Gedeon I, Vuong PN
Diagn Cytopathol 2002 Nov;27(5):291-3. doi: 10.1002/dc.10186. PMID: 12411995
Invasive squamous-cell carcinoma in ThinPrep specimens: diagnostic clues in the cellular pattern.
Clark SB, Dawson AE
Diagn Cytopathol 2002 Jan;26(1):1-4. doi: 10.1002/dc.10033. PMID: 11782077

Clinical prediction guides

Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein.
Tahara U, Matsui T, Atsugi T, Fukuda K, Terooatea TW, Minoda A, Kubo A, Amagai M
J Invest Dermatol 2023 Dec;143(12):2346-2355.e10. doi: 10.1016/j.jid.2023.08.008. PMID: 37981423
Epidermoid carcinoma in the neovagina of a patient with Mayer-Rokitansky-Küster-Hauser syndrome. Case report and literature review.
Fernández-Ruiz M, Pantoja-Garrido M, Frías-Sánchez Z, Rodríguez-Jiménez I, Aguilar-Martín MDV
Rev Colomb Obstet Ginecol 2019 Dec;70(4):266-276. doi: 10.18597/rcog.3328. PMID: 32142241
Urothelial carcinoma involving vaginal specimens from patients with neobladder: a potential pitfall in diagnostic cytopathology.
Sigel CS, Park KJ, Fine SW, Lin O
Diagn Cytopathol 2012 Feb;40(2):168-72. Epub 2010 Dec 31 doi: 10.1002/dc.21600. PMID: 22246935
The role of steroid contraceptive hormones in the pathogenesis of invasive cervical cancer: a review.
Moodley M, Moodley J, Chetty R, Herrington CS
Int J Gynecol Cancer 2003 Mar-Apr;13(2):103-10. doi: 10.1046/j.1525-1438.2003.13030.x. PMID: 12657108
Invasive squamous-cell carcinoma in ThinPrep specimens: diagnostic clues in the cellular pattern.
Clark SB, Dawson AE
Diagn Cytopathol 2002 Jan;26(1):1-4. doi: 10.1002/dc.10033. PMID: 11782077

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