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Appendix adenoma

MedGen UID:: 312900
•Concept ID:: C1706829
•: Neoplastic Process

Synonyms:	Appendix Adenoma; appendix adenoma; vermiform appendix adenoma

Monarch Initiative:	MONDO:0006088

Definition

A circumscribed neoplasm arising from the glandular epithelium of the appendix. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. The dysplasia is classified as mild, moderate, or severe. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAppendix adenoma

Disorder of gastrointestinal tract
- Intestinal disorder
  - Cecal disorder
    - Cecal neoplasm
      - Appendiceal neoplasm
        Benign neoplasm of appendix
        Appendix adenoma
        Appendix Mucinous Cystadenoma
        Appendix Serrated Lesions and Polyps
        Appendix Traditional Serrated Adenoma
        Appendix Tubular Adenoma
        Appendix Tubulovillous Adenoma
        Appendix villous adenoma

Professional guidelines

PubMed

Combined Endoscopic Mucosal Resection and Extended Laparoscopic Appendectomy for the Treatment of Periappendiceal, Cecal, and Appendiceal Adenomas.

Huang ES, Chumfong IT, Alkoraishi AS, Munroe CA
J Surg Res 2020 Aug;252:89-95. Epub 2020 Apr 8 doi: 10.1016/j.jss.2020.02.006. PMID: 32278221

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Carr NJ, Bibeau F, Bradley RF, Dartigues P, Feakins RM, Geisinger KR, Gui X, Isaac S, Milione M, Misdraji J, Pai RK, Rodriguez-Justo M, Sobin LH, van Velthuysen MF, Yantiss RK
Histopathology 2017 Dec;71(6):847-858. Epub 2017 Sep 19 doi: 10.1111/his.13324. PMID: 28746986

Diagnosis and management of pediatric endocrine neoplasms.

Iqbal CW, Wahoff DC
Curr Opin Pediatr 2009 Jun;21(3):379-85. doi: 10.1097/MOP.0b013e32832b335e. PMID: 19421059

See all (6)

Recent clinical studies

Etiology

Neoplasms of the Appendix.

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595 Free PMC Article

Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.

Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Apudomas.

Nakano PH, Bloom RR, Brown BC, Gray SW, Skandalakis JE, Kibbe JM
Am Surg 1987 Sep;53(9):505-9. PMID: 2820286

See all (112)

Diagnosis

Ectopic insulinoma: a systematic review.

Guerrero-Pérez F, Vilarrasa N, Huánuco LV, Busquets J, Secanella L, Vercher-Conejero JL, Vidal N, Näf Cortés S, Villabona C
Rev Endocr Metab Disord 2023 Dec;24(6):1135-1146. Epub 2023 Jul 12 doi: 10.1007/s11154-023-09824-2. PMID: 37434098

Neoplasms of the Appendix.

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595 Free PMC Article

The histopathological classification, diagnosis and differential diagnosis of mucinous appendiceal neoplasms, appendiceal adenocarcinomas and pseudomyxoma peritonei.

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Pseudomyxoma peritonei.

Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579

See all (226)

Therapy

Neoplasms of the Appendix.

Köhler F, Matthes N, Rosenfeldt M, Kunzmann V, Germer CT, Wiegering A
Dtsch Arztebl Int 2023 Aug 7;120(31-32):519-525. doi: 10.3238/arztebl.m2023.0136. PMID: 37282595 Free PMC Article

Acute appendicitis after colorectal endoscopic mucosal resection: a case report.

Liu Y, Wang H, Yin XY, Wang T, Liu J, Wu L, Hu LH, Wang FY
J Int Med Res 2022 May;50(5):3000605221096273. doi: 10.1177/03000605221096273. PMID: 35574813 Free PMC Article

Faecal retention: a common cause in functional bowel disorders, appendicitis and haemorrhoids--with medical and surgical therapy.

Raahave D
Dan Med J 2015 Mar;62(3) PMID: 25748875

Pseudomyxoma peritonei syndrome of appendiceal origin: an overview.

Brueggen C, Baird G, Meisheid A
Clin J Oncol Nurs 2007 Aug;11(4):525-32. doi: 10.1188/07.CJON.525-532. PMID: 17723965

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

See all (24)

Prognosis

Clinicopathologic parameters and outcomes of mucinous neoplasms confined to the appendix: a benign entity with excellent prognosis.

Polydorides AD, Wen X
Mod Pathol 2022 Nov;35(11):1732-1739. Epub 2022 Jun 8 doi: 10.1038/s41379-022-01114-7. PMID: 35676331

Mucocoele and mucinous tumours of the appendix: A review of the literature.

Rymer B, Forsythe RO, Husada G
Int J Surg 2015 Jun;18:132-5. Epub 2015 Apr 24 doi: 10.1016/j.ijsu.2015.04.052. PMID: 25917270

Pseudomyxoma peritonei.

Hinson FL, Ambrose NS
Br J Surg 1998 Oct;85(10):1332-9. doi: 10.1046/j.1365-2168.1998.00882.x. PMID: 9782010

Unusual tumors of the appendix and pseudomyxoma peritonei.

Carr NJ, Sobin LH
Semin Diagn Pathol 1996 Nov;13(4):314-25. PMID: 8946609

Pseudomyxoma peritonei.

Sugarbaker PH
Cancer Treat Res 1996;81:105-19. doi: 10.1007/978-1-4613-1245-1_10. PMID: 8834579

See all (83)

Clinical prediction guides

FABP1 expression in human tumors: a tissue microarray study on 17,071 tumors.

Dum D, Ocokoljic A, Lennartz M, Hube-Magg C, Reiswich V, Höflmayer D, Jacobsen F, Bernreuther C, Lebok P, Sauter G, Luebke AM, Burandt E, Marx AH, Simon R, Clauditz TS, Minner S, Menz A, Büscheck F, Gorbokon N, Steurer S, Blessin NC, Krech T
Virchows Arch 2022 Dec;481(6):945-961. Epub 2022 Aug 11 doi: 10.1007/s00428-022-03394-5. PMID: 35951102 Free PMC Article

Clinical characteristics of appendiceal diverticular disease.

Çakar E, Bayrak S, Çolak Ş, Dal F, Gürbulak B, Bektaş H, Yarıkkaya E, Ferlengez AG
Int J Colorectal Dis 2019 Dec;34(12):2035-2041. Epub 2019 Nov 4 doi: 10.1007/s00384-019-03410-2. PMID: 31686198

Lymph Node Metastasis Predicts Disease Recurrence in a Single-Center Experience of 70 Stages 1-3 Appendix Cancers: A Retrospective Review.

Nash GM, Smith JD, Tang L, Weiser MR, Temple LK, O'Reilly E, Saltz LB, Guillem JG, Paty PB
Ann Surg Oncol 2015 Oct;22(11):3613-7. Epub 2015 Feb 7 doi: 10.1245/s10434-015-4415-5. PMID: 25663593 Free PMC Article

Pseudomyxoma peritonei syndrome of appendiceal origin: an overview.

Brueggen C, Baird G, Meisheid A
Clin J Oncol Nurs 2007 Aug;11(4):525-32. doi: 10.1188/07.CJON.525-532. PMID: 17723965

Tumors of the appendix.

Schmutzer KJ, Bayar M, Zaki AE, Regan JF, Poletti JB
Dis Colon Rectum 1975 May-Jun;18(4):324-31. doi: 10.1007/BF02587395. PMID: 1126268

See all (39)