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Colorectal signet ring cell carcinoma

MedGen UID:
313040
•Concept ID:
C1707440
•
Neoplastic Process
Synonyms: Colorectal Signet Ring Cell Carcinoma; colorectal signet ring cell carcinoma; colorectal signet Ring cell carcinoma; Colorectal Signet-Ring Cell Carcinoma
 
Monarch Initiative: MONDO:0044336

Definition

An invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate. [from NCI]

Professional guidelines

PubMed

Primary colorectal signet-ring cell carcinoma in Singapore.
Ooi BS, Ho YH, Eu KW, Seow Choen F
ANZ J Surg 2001 Dec;71(12):703-6. doi: 10.1046/j.1445-1433.2001.02269.x. PMID: 11906382
Ordinary colorectal adenocarcinoma vs. primary colorectal signet-ring cell carcinoma: study matched for age, gender, grade, and stage.
Psathakis D, Schiedeck TH, Krug F, Oevermann E, Kujath P, Bruch HP
Dis Colon Rectum 1999 Dec;42(12):1618-25. doi: 10.1007/BF02236218. PMID: 10613484

Recent clinical studies

Etiology

Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma.
Diao JD, Ma LX, Wu CJ, Liu XH, Su XY, Bi HY, Bao B, Yan HW, Shi L, Yang YJ
Sci Rep 2021 Feb 9;11(1):3382. doi: 10.1038/s41598-021-82978-8. PMID: 33564088Free PMC Article
Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study.
Yang LL, Wang M, He P
Sci Rep 2020 Jun 26;10(1):10460. doi: 10.1038/s41598-020-67388-6. PMID: 32591589Free PMC Article
Colorectal signet ring cell carcinoma: Influence of EGFR, E-cadherin and MMP-13 expression on clinicopathological features and prognosis.
Foda AAM, Aziz AA, Mohamed MA
Ann Diagn Pathol 2018 Feb;32:41-46. Epub 2017 Oct 16 doi: 10.1016/j.anndiagpath.2017.10.003. PMID: 29414397
Clinical Analysis of Primary Colorectal Signet-Ring Cell Carcinoma.
Liang Z, Yan D, Li G, Cheng H
Clin Colorectal Cancer 2018 Mar;17(1):e39-e44. Epub 2017 Jul 8 doi: 10.1016/j.clcc.2017.06.010. PMID: 28789931
Colorectal signet-ring cell carcinoma: benefit from adjuvant chemotherapy but a poor prognostic factor.
Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH
Int J Cancer 2015 Jan 15;136(2):333-9. Epub 2014 May 28 doi: 10.1002/ijc.28981. PMID: 24841868

Diagnosis

Colorectal signet-ring cell carcinoma treated with FOLFOX plus panitumumab.
Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Goto J, Kobayashi K
Pediatr Int 2022 Jan;64(1):e15374. doi: 10.1111/ped.15374. PMID: 36169041
CDH1 gene mutation in early-onset, colorectal signet-ring cell carcinoma.
Aitchison A, Hakkaart C, Whitehead M, Khan S, Siddique S, Ahmed R, Frizelle FA, Keenan JI
Pathol Res Pract 2020 May;216(5):152912. Epub 2020 Feb 29 doi: 10.1016/j.prp.2020.152912. PMID: 32147272
Clinical Analysis of Primary Colorectal Signet-Ring Cell Carcinoma.
Liang Z, Yan D, Li G, Cheng H
Clin Colorectal Cancer 2018 Mar;17(1):e39-e44. Epub 2017 Jul 8 doi: 10.1016/j.clcc.2017.06.010. PMID: 28789931
Signet-ring cell carcinoma of colorectum--current perspectives and molecular biology.
Gopalan V, Smith RA, Ho YH, Lam AK
Int J Colorectal Dis 2011 Feb;26(2):127-33. Epub 2010 Aug 5 doi: 10.1007/s00384-010-1037-z. PMID: 20686774
Primary signet-ring cell carcinoma of the colon and rectum.
Messerini L, Palomba A, Zampi G
Dis Colon Rectum 1995 Nov;38(11):1189-92. doi: 10.1007/BF02048335. PMID: 7587762

Therapy

Colorectal signet-ring cell carcinoma treated with FOLFOX plus panitumumab.
Matsushima S, Kobayashi R, Sano H, Hori D, Yanagi M, Goto J, Kobayashi K
Pediatr Int 2022 Jan;64(1):e15374. doi: 10.1111/ped.15374. PMID: 36169041
Chemotherapy is associated with increased survival from colorectal signet ring cell carcinoma with distant metastasis: A Surveillance, Epidemiology, and End Results database analysis.
Shi T, Huang M, Han D, Tang X, Chen Y, Li Z, Liu C, Xiang D, Wang T, Chen Y, Wang R, Lei Z, Chu X
Cancer Med 2019 Apr;8(4):1930-1940. Epub 2019 Mar 12 doi: 10.1002/cam4.2054. PMID: 30864303Free PMC Article
Colorectal signet-ring cell carcinoma: benefit from adjuvant chemotherapy but a poor prognostic factor.
Hugen N, Verhoeven RH, Lemmens VE, van Aart CJ, Elferink MA, Radema SA, Nagtegaal ID, de Wilt JH
Int J Cancer 2015 Jan 15;136(2):333-9. Epub 2014 May 28 doi: 10.1002/ijc.28981. PMID: 24841868

Prognosis

Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Clinicopathological characteristics and survival in colorectal signet ring cell carcinoma: a population-based study.
Yang LL, Wang M, He P
Sci Rep 2020 Jun 26;10(1):10460. doi: 10.1038/s41598-020-67388-6. PMID: 32591589Free PMC Article
CDH1 gene mutation in early-onset, colorectal signet-ring cell carcinoma.
Aitchison A, Hakkaart C, Whitehead M, Khan S, Siddique S, Ahmed R, Frizelle FA, Keenan JI
Pathol Res Pract 2020 May;216(5):152912. Epub 2020 Feb 29 doi: 10.1016/j.prp.2020.152912. PMID: 32147272
Colorectal signet ring cell carcinoma: Influence of EGFR, E-cadherin and MMP-13 expression on clinicopathological features and prognosis.
Foda AAM, Aziz AA, Mohamed MA
Ann Diagn Pathol 2018 Feb;32:41-46. Epub 2017 Oct 16 doi: 10.1016/j.anndiagpath.2017.10.003. PMID: 29414397
Clinicopathological and Corresponding Genetic Features of Colorectal Signet Ring Cell Carcinoma.
Tajiri K, Sudou T, Fujita F, Hisaka T, Kinugasa T, Akagi Y
Anticancer Res 2017 Jul;37(7):3817-3823. doi: 10.21873/anticanres.11760. PMID: 28668881

Clinical prediction guides

Clinicopathologic and prognostic factors of patients with T3/T4 colorectal signet ring cell carcinoma: a population-based study.
Zhang F, Xu B, Peng Y, Mao Z
J Cancer Res Clin Oncol 2023 Sep;149(12):9747-9756. Epub 2023 May 28 doi: 10.1007/s00432-023-04880-2. PMID: 37245170Free PMC Article
The prognostic significance of different proportion of signet-ring cells of colorectal carcinoma.
Chen W, Cai H, Chen K, Liu X, Jiang W, Li S, Zhang Y, Chen Z, Guan G
Bosn J Basic Med Sci 2022 Feb 1;22(1):124-130. doi: 10.17305/bjbms.2021.5856. PMID: 34247568Free PMC Article
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
Construction and validation a nomogram to predict overall survival for colorectal signet ring cell carcinoma.
Diao JD, Ma LX, Wu CJ, Liu XH, Su XY, Bi HY, Bao B, Yan HW, Shi L, Yang YJ
Sci Rep 2021 Feb 9;11(1):3382. doi: 10.1038/s41598-021-82978-8. PMID: 33564088Free PMC Article
Primary colorectal signet-ring cell carcinoma: clinicopathological features and postoperative survival.
Mizushima T, Nomura M, Fujii M, Akamatsu H, Mizuno H, Tominaga H, Hasegawa J, Nakajima K, Yasumasa K, Yoshikawa M, Nishida T
Surg Today 2010 Mar;40(3):234-8. Epub 2010 Feb 24 doi: 10.1007/s00595-009-4057-y. PMID: 20180076

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