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Colorectal Small Cell Neuroendocrine Carcinoma

MedGen UID:
313041
Concept ID:
C1707441
Neoplastic Process
Synonyms: Colorectal Small Cell Carcinoma; Large Intestinal Small Cell Neuroendocrine Carcinoma

Definition

An aggressive, high-grade, and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the colon or rectum. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874
Ciardiello F, Tortora G
N Engl J Med 2008 Mar 13;358(11):1160-74. doi: 10.1056/NEJMra0707704. PMID: 18337605

Recent clinical studies

Etiology

Sacher A, LoRusso P, Patel MR, Miller WH Jr, Garralda E, Forster MD, Santoro A, Falcon A, Kim TW, Paz-Ares L, Bowyer S, de Miguel M, Han SW, Krebs MG, Lee JS, Cheng ML, Arbour K, Massarelli E, Choi Y, Shi Z, Mandlekar S, Lin MT, Royer-Joo S, Chang J, Dharia NV, Schutzman JL, Desai J; GO42144 Investigator and Study Group
N Engl J Med 2023 Aug 24;389(8):710-721. doi: 10.1056/NEJMoa2303810. PMID: 37611121
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Gould MK, Huang BZ, Tammemagi MC, Kinar Y, Shiff R
Am J Respir Crit Care Med 2021 Aug 15;204(4):445-453. doi: 10.1164/rccm.202007-2791OC. PMID: 33823116
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Diagnosis

Schrörs B, Hos BJ, Yildiz IG, Löwer M, Lang F, Holtsträter C, Becker J, Vormehr M, Sahin U, Ossendorp F, Diken M
Front Immunol 2023;14:1102282. Epub 2023 Mar 8 doi: 10.3389/fimmu.2023.1102282. PMID: 36969213Free PMC Article
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Zhu G, Cheng Z, Huang Y, Zheng W, Yang S, Lin C, Ye J
Int J Mol Med 2020 Jan;45(1):131-140. Epub 2019 Oct 31 doi: 10.3892/ijmm.2019.4390. PMID: 31746347Free PMC Article
Dijkstra KK, Cattaneo CM, Weeber F, Chalabi M, van de Haar J, Fanchi LF, Slagter M, van der Velden DL, Kaing S, Kelderman S, van Rooij N, van Leerdam ME, Depla A, Smit EF, Hartemink KJ, de Groot R, Wolkers MC, Sachs N, Snaebjornsson P, Monkhorst K, Haanen J, Clevers H, Schumacher TN, Voest EE
Cell 2018 Sep 6;174(6):1586-1598.e12. Epub 2018 Aug 9 doi: 10.1016/j.cell.2018.07.009. PMID: 30100188Free PMC Article

Therapy

Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538
Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, Jänne PA, Aguirre AJ
N Engl J Med 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. PMID: 34161704Free PMC Article
Balakrishna P, George S, Hatoum H, Mukherjee S
Int J Mol Sci 2021 Jan 28;22(3) doi: 10.3390/ijms22031268. PMID: 33525332Free PMC Article
Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL
Cancer Treat Rev 2020 Jun;86:102017. Epub 2020 Mar 26 doi: 10.1016/j.ctrv.2020.102017. PMID: 32335505
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M
N Engl J Med 2012 Jun 28;366(26):2443-54. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200690. PMID: 22658127Free PMC Article

Prognosis

Zhao W, Jin L, Chen P, Li D, Gao W, Dong G
Cancer Lett 2022 Oct 1;545:215816. Epub 2022 Jul 8 doi: 10.1016/j.canlet.2022.215816. PMID: 35810989
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Zhu G, Cheng Z, Huang Y, Zheng W, Yang S, Lin C, Ye J
Int J Mol Med 2020 Jan;45(1):131-140. Epub 2019 Oct 31 doi: 10.3892/ijmm.2019.4390. PMID: 31746347Free PMC Article
Dankner M, Rose AAN, Rajkumar S, Siegel PM, Watson IR
Oncogene 2018 Jun;37(24):3183-3199. Epub 2018 Mar 15 doi: 10.1038/s41388-018-0171-x. PMID: 29540830
Mazzarella L, Guida A, Curigliano G
Expert Opin Biol Ther 2018 Apr;18(4):483-493. doi: 10.1080/14712598.2018.1452906. PMID: 29534625

Clinical prediction guides

Zhao W, Jin L, Chen P, Li D, Gao W, Dong G
Cancer Lett 2022 Oct 1;545:215816. Epub 2022 Jul 8 doi: 10.1016/j.canlet.2022.215816. PMID: 35810989
Ou SI, Jänne PA, Leal TA, Rybkin II, Sabari JK, Barve MA, Bazhenova L, Johnson ML, Velastegui KL, Cilliers C, Christensen JG, Yan X, Chao RC, Papadopoulos KP
J Clin Oncol 2022 Aug 10;40(23):2530-2538. Epub 2022 Feb 15 doi: 10.1200/JCO.21.02752. PMID: 35167329Free PMC Article
Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, Jänne PA, Aguirre AJ
N Engl J Med 2021 Jun 24;384(25):2382-2393. doi: 10.1056/NEJMoa2105281. PMID: 34161704Free PMC Article
Dankner M, Rose AAN, Rajkumar S, Siegel PM, Watson IR
Oncogene 2018 Jun;37(24):3183-3199. Epub 2018 Mar 15 doi: 10.1038/s41388-018-0171-x. PMID: 29540830
Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, Powderly JD, Carvajal RD, Sosman JA, Atkins MB, Leming PD, Spigel DR, Antonia SJ, Horn L, Drake CG, Pardoll DM, Chen L, Sharfman WH, Anders RA, Taube JM, McMiller TL, Xu H, Korman AJ, Jure-Kunkel M, Agrawal S, McDonald D, Kollia GD, Gupta A, Wigginton JM, Sznol M
N Engl J Med 2012 Jun 28;366(26):2443-54. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200690. PMID: 22658127Free PMC Article

Recent systematic reviews

Prelaj A, Miskovic V, Zanitti M, Trovo F, Genova C, Viscardi G, Rebuzzi SE, Mazzeo L, Provenzano L, Kosta S, Favali M, Spagnoletti A, Castelo-Branco L, Dolezal J, Pearson AT, Lo Russo G, Proto C, Ganzinelli M, Giani C, Ambrosini E, Turajlic S, Au L, Koopman M, Delaloge S, Kather JN, de Braud F, Garassino MC, Pentheroudakis G, Spencer C, Pedrocchi ALG
Ann Oncol 2024 Jan;35(1):29-65. Epub 2023 Oct 23 doi: 10.1016/j.annonc.2023.10.125. PMID: 37879443
Pan B, Lai H, Ma N, Li D, Deng X, Wang X, Zhang Q, Yang Q, Wang Q, Zhu H, Li M, Cao X, Tian J, Ge L, Yang K
Int J Behav Nutr Phys Act 2023 May 15;20(1):58. doi: 10.1186/s12966-023-01459-5. PMID: 37189146Free PMC Article
Zhu Y, Liu C, Xu Z, Zou Z, Xie T, Xing P, Wang L, Li J
Chin Med J (Engl) 2023 Nov 5;136(21):2551-2561. doi: 10.1097/CM9.0000000000002468. PMID: 37160733Free PMC Article
Pedersen TB, Kildsig J, Serup-Hansen E, Gocht-Jensen P, Klein MF
Int J Colorectal Dis 2020 Sep;35(9):1663-1671. Epub 2020 Jul 15 doi: 10.1007/s00384-020-03687-8. PMID: 32671458
Wang HH, Zhang CZ, Zhang BL, Chen J, Zeng XL, Deng L, Meng MB
Oncotarget 2017 Jan 24;8(4):6033-6042. doi: 10.18632/oncotarget.14010. PMID: 28002808Free PMC Article

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