U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HIV Lipodystrophy

MedGen UID:
313244
•Concept ID:
C1708272
•
Neoplastic Process
Synonym: HIV-Lipodystrophy

Definition

A neoplastic process characterized by a diffuse poorly circumscribed overgrowth of adipose tissue in the breast and cervical areas, and an accumulation of visceral fat. It is associated with antiretroviral therapy. Clinical presentation includes hyperlipidemia, insulin resistance, and fat atrophy of the face and limbs. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHIV Lipodystrophy

Professional guidelines

PubMed

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177
HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.
Carr A
AIDS 2003 Apr;17 Suppl 1:S141-8. PMID: 12870540

Recent clinical studies

Etiology

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'.
Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ
Curr Opin Lipidol 2004 Feb;15(1):59-67. doi: 10.1097/00041433-200402000-00011. PMID: 15166810
HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.
Carr A
AIDS 2003 Apr;17 Suppl 1:S141-8. PMID: 12870540

Diagnosis

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'.
Balasubramanyam A, Sekhar RV, Jahoor F, Jones PH, Pownall HJ
Curr Opin Lipidol 2004 Feb;15(1):59-67. doi: 10.1097/00041433-200402000-00011. PMID: 15166810
HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management.
Carr A
AIDS 2003 Apr;17 Suppl 1:S141-8. PMID: 12870540
HIV lipodystrophy diagnosis and management. Body composition and metabolic alterations: diagnosis and management.
Engelson ES
AIDS Read 2003 Apr;13(4 Suppl):S10-4. PMID: 12762288

Therapy

Metreleptin treatment of non-HIV lipodystrophy syndromes.
Chevalier B, Lemaitre M, Leguier L, Mapihan KL, Douillard C, Jannin A, Espiard S, Vantyghem MC
Presse Med 2021 Nov;50(3):104070. Epub 2021 Sep 24 doi: 10.1016/j.lpm.2021.104070. PMID: 34571177
Therapy for HIV: past, present, and future.
Peters BS, Conway K
Adv Dent Res 2011 Apr;23(1):23-7. doi: 10.1177/0022034511399082. PMID: 21441476
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Pharmacologic therapy for HIV-associated lipodystrophy.
Benavides S, Nahata MC
Ann Pharmacother 2004 Mar;38(3):448-57. Epub 2004 Jan 30 doi: 10.1345/aph.1D081. PMID: 14755064
HIV lipodystrophy diagnosis and management. Body composition and metabolic alterations: diagnosis and management.
Engelson ES
AIDS Read 2003 Apr;13(4 Suppl):S10-4. PMID: 12762288

Prognosis

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Soft tissue augmentation with PMMA-microspheres for the treatment of HIV-associated buttock lipodystrophy.
Serra MS, Gonçalves LZ, Ramos-e-Silva M
Int J STD AIDS 2015 Mar;26(4):279-84. Epub 2014 May 22 doi: 10.1177/0956462414536878. PMID: 24855130
HIV lipodystrophy and its metabolic consequences: implications for clinical practice.
Wierzbicki AS, Purdon SD, Hardman TC, Kulasegaram R, Peters BS
Curr Med Res Opin 2008 Mar;24(3):609-24. doi: 10.1185/030079908X272742. PMID: 18208641
Adipose tissue lipin expression levels distinguish HIV patients with and without lipodystrophy.
Lindegaard B, Larsen LF, Hansen AB, Gerstoft J, Pedersen BK, Reue K
Int J Obes (Lond) 2007 Mar;31(3):449-56. Epub 2006 Jul 18 doi: 10.1038/sj.ijo.0803434. PMID: 16847472
HIV-associated lipodystrophy: pathogenesis, prognosis, treatment, and controversies.
Koutkia P, Grinspoon S
Annu Rev Med 2004;55:303-17. doi: 10.1146/annurev.med.55.091902.104412. PMID: 14746523

Clinical prediction guides

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review.
Long MT, Noureddin M, Lim JK
Gastroenterology 2022 Sep;163(3):764-774.e1. Epub 2022 Jul 14 doi: 10.1053/j.gastro.2022.06.023. PMID: 35842345Free PMC Article
Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy.
Domingo P, Giralt M, Gavaldà-Navarro A, Blasco-Roset A, Delgado-Anglés A, Gallego-Escuredo JM, Gutiérrez MDM, Mateo MG, Cereijo R, Domingo JC, Villarroya F, Villarroya J
Adipocyte 2022 Dec;11(1):143-152. doi: 10.1080/21623945.2022.2042962. PMID: 35300561Free PMC Article
Metformin: the hidden chronicles of a magic drug.
Mahmood K, Naeem M, Rahimnajjad NA
Eur J Intern Med 2013 Jan;24(1):20-6. Epub 2012 Nov 21 doi: 10.1016/j.ejim.2012.10.011. PMID: 23177353
The association of lipodystrophy and oxidative stress biomarkers in HIV-infected men.
Vassimon HS, Deminice R, Machado AA, Monteiro JP, Jordao AA
Curr HIV Res 2010 Jul;8(5):364-9. doi: 10.2174/157016210791330347. PMID: 20353389
Cardiovascular complications in the acquired immunodeficiency syndrome.
Barbaro G, Silva EF
Rev Assoc Med Bras (1992) 2009 Sep-Oct;55(5):621-30. doi: 10.1590/s0104-42302009000500031. PMID: 19918668

Recent systematic reviews

A systematic review of filler agents for aesthetic treatment of HIV facial lipoatrophy (FLA).
Jagdeo J, Ho D, Lo A, Carruthers A
J Am Acad Dermatol 2015 Dec;73(6):1040-54.e14. Epub 2015 Oct 23 doi: 10.1016/j.jaad.2015.08.040. PMID: 26481056

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...