Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Laryngeal Lymphoepithelial Carcinoma

MedGen UID:: 313340
•Concept ID:: C1708653
•: Neoplastic Process

Synonyms:

Laryngeal Lymphoepithelioma; Laryngeal Undifferentiated Carcinoma of the Nasopharyngeal Type

Definition

A rare and aggressive carcinoma that arises from the larynx. It is characterized by the presence of an undifferentiated carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLaryngeal Lymphoepithelial Carcinoma

Head and neck neoplasm
- Head and neck cancer
  - Malignant tumor of neck
    - Larynx cancer
      - Laryngeal carcinoma
        Laryngeal Undifferentiated Carcinoma
        Laryngeal Lymphoepithelial Carcinoma

Professional guidelines

PubMed

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287

See all (1)

Recent clinical studies

Etiology

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.

Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Lymphoepithelial-like carcinomas of the head and neck.

Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Clinicopathological study of undifferentiated carcinoma of the parotid gland.

Hatta C, Terada T, Okita J, Kakibuchi M, Kubota A, Sakagami M
Auris Nasus Larynx 2003 Aug;30(3):273-7. doi: 10.1016/s0385-8146(03)00096-8. PMID: 12927291

See all (4)

Diagnosis

Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma.

Acuña G, Gomà M, Temprana-Salvador J, Garcia-Bragado F, Alós L, Ordi J, Cardesa A, Nadal A
Mod Pathol 2019 May;32(5):621-626. Epub 2018 Dec 14 doi: 10.1038/s41379-018-0188-2. PMID: 30552415

Systemic therapy in non-conventional cancers of the larynx.

Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?

Lymphoepithelial-like carcinomas of the head and neck.

Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Clinicopathological consultation. Lymphoepithelial carcinoma of the larynx hypopharynx, and trachea.

Ferlito A, Weiss LM, Rinaldo A, Carbone A, Devaney KO, MacMillan C, Barnes L
Ann Otol Rhinol Laryngol 1997 May;106(5):437-44. doi: 10.1177/000348949710600514. PMID: 9153110

See all (18)

Therapy

Systemic therapy in non-conventional cancers of the larynx.

Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903

Head and neck lesions in the immunocompromised host.

Marsot-Dupuch K, Quillard J, Meyohas MC
Eur Radiol 2004 Mar;14 Suppl 3:E155-67. doi: 10.1007/s00330-003-2045-y. PMID: 14749957

See all (2)

Prognosis

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.

Larynx lymphoepithelial carcinoma: surgical management.

Galletti C, Pizzimenti C, Cavallari V, Galletti B
BMJ Case Rep 2021 Jul 20;14(7) doi: 10.1136/bcr-2020-241460. PMID: 34285018 Free PMC Article

Lymphoepithelial-like carcinomas of the head and neck.

Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Clinicopathological consultation. Lymphoepithelial carcinoma of the larynx hypopharynx, and trachea.

Ferlito A, Weiss LM, Rinaldo A, Carbone A, Devaney KO, MacMillan C, Barnes L
Ann Otol Rhinol Laryngol 1997 May;106(5):437-44. doi: 10.1177/000348949710600514. PMID: 9153110

Lymphoepithelial carcinoma of the larynx and hypopharynx: study of eight cases with relationship to Epstein-Barr virus and p53 gene alterations, and review of the literature.

MacMillan C, Kapadia SB, Finkelstein SD, Nalesnik MA, Barnes L
Hum Pathol 1996 Nov;27(11):1172-9. doi: 10.1016/s0046-8177(96)90311-1. PMID: 8912827

See all (8)

Clinical prediction guides

Human papillomavirus in laryngeal and hypopharyngeal lymphoepithelial carcinoma.

Acuña G, Gomà M, Temprana-Salvador J, Garcia-Bragado F, Alós L, Ordi J, Cardesa A, Nadal A
Mod Pathol 2019 May;32(5):621-626. Epub 2018 Dec 14 doi: 10.1038/s41379-018-0188-2. PMID: 30552415

Lymphoepithelial-like carcinomas of the head and neck.

Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Association of p53 and BCL-2 expression with Epstein-Barr virus infection in the cancers of head and neck.

Yang HJ, Cho YJ, Kim HS, Chang MS, Sung MW, Kim WH
Head Neck 2001 Aug;23(8):629-36. doi: 10.1002/hed.1089. PMID: 11443745

See all (3)