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Pilar-Associated Mesenchyme Neoplasm

MedGen UID:
313583
•Concept ID:
C1709539
•
Neoplastic Process
Synonym: Pilar-Associated Mesenchyme Tumor

Definition

A mesenchymal neoplasm arising from the pilar sheath of the hair follicle. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPilar-Associated Mesenchyme Neoplasm

Professional guidelines

PubMed

Uterine Neoplasms, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Abu-Rustum N, Yashar C, Arend R, Barber E, Bradley K, Brooks R, Campos SM, Chino J, Chon HS, Chu C, Crispens MA, Damast S, Fisher CM, Frederick P, Gaffney DK, Giuntoli R, Han E, Holmes J, Howitt BE, Lea J, Mariani A, Mutch D, Nagel C, Nekhlyudov L, Podoll M, Salani R, Schorge J, Siedel J, Sisodia R, Soliman P, Ueda S, Urban R, Wethington SL, Wyse E, Zanotti K, McMillian NR, Aggarwal S
J Natl Compr Canc Netw 2023 Feb;21(2):181-209. doi: 10.6004/jnccn.2023.0006. PMID: 36791750
From COPD to Lung Cancer: Mechanisms Linking, Diagnosis, Treatment, and Prognosis.
Qi C, Sun SW, Xiong XZ
Int J Chron Obstruct Pulmon Dis 2022;17:2603-2621. Epub 2022 Oct 17 doi: 10.2147/COPD.S380732. PMID: 36274992Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Chondrosarcoma.
Weinschenk RC, Wang WL, Lewis VO
J Am Acad Orthop Surg 2021 Jul 1;29(13):553-562. doi: 10.5435/JAAOS-D-20-01188. PMID: 33595238
lnflammation-induced epigenetic switches in cancer.
Rokavec M, Öner MG, Hermeking H
Cell Mol Life Sci 2016 Jan;73(1):23-39. Epub 2015 Sep 22 doi: 10.1007/s00018-015-2045-5. PMID: 26394635Free PMC Article
Review literature on uterine carcinosarcoma.
Singh R
J Cancer Res Ther 2014 Jul-Sep;10(3):461-8. doi: 10.4103/0973-1482.138197. PMID: 25313723
Ameloblastic fibrodentinoma.
Bhargava D, Dave A, Sharma B, Nanda KD
Indian J Dent Res 2011 Mar-Apr;22(2):345-7. doi: 10.4103/0970-9290.84287. PMID: 21891911
Sarcoma.
Skubitz KM, D'Adamo DR
Mayo Clin Proc 2007 Nov;82(11):1409-32. doi: 10.4065/82.11.1409. PMID: 17976362

Diagnosis

Mesenchymal Neoplasms of the Liver.
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS
Nat Commun 2018 May 3;9(1):1777. doi: 10.1038/s41467-018-04179-8. PMID: 29725014Free PMC Article
Epithelial Mesenchymal Transition in Tumor Metastasis.
Mittal V
Annu Rev Pathol 2018 Jan 24;13:395-412. doi: 10.1146/annurev-pathol-020117-043854. PMID: 29414248
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells.
Lawson DA, Bhakta NR, Kessenbrock K, Prummel KD, Yu Y, Takai K, Zhou A, Eyob H, Balakrishnan S, Wang CY, Yaswen P, Goga A, Werb Z
Nature 2015 Oct 1;526(7571):131-5. Epub 2015 Sep 23 doi: 10.1038/nature15260. PMID: 26416748Free PMC Article
Placental mesenchymal dysplasia.
Pawoo N, Heller DS
Arch Pathol Lab Med 2014 Sep;138(9):1247-9. doi: 10.5858/arpa.2013-0399-RS. PMID: 25171710

Therapy

Mesenchymal-like Tumor Cells and Myofibroblastic Cancer-Associated Fibroblasts Are Associated with Progression and Immunotherapy Response of Clear Cell Renal Cell Carcinoma.
Davidson G, Helleux A, Vano YA, Lindner V, Fattori A, Cerciat M, Elaidi RT, Verkarre V, Sun CM, Chevreau C, Bennamoun M, Lang H, Tricard T, Fridman WH, Sautes-Fridman C, Su X, Plassard D, Keime C, Thibault-Carpentier C, Barthelemy P, Oudard SM, Davidson I, Malouf GG
Cancer Res 2023 Sep 1;83(17):2952-2969. doi: 10.1158/0008-5472.CAN-22-3034. PMID: 37335139
Savolitinib: First Approval.
Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538
Uterine carcinosarcoma: Contemporary clinical summary, molecular updates, and future research opportunity.
Matsuzaki S, Klar M, Matsuzaki S, Roman LD, Sood AK, Matsuo K
Gynecol Oncol 2021 Feb;160(2):586-601. Epub 2020 Nov 9 doi: 10.1016/j.ygyno.2020.10.043. PMID: 33183764
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS
Nat Commun 2018 May 3;9(1):1777. doi: 10.1038/s41467-018-04179-8. PMID: 29725014Free PMC Article
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications.
Shibue T, Weinberg RA
Nat Rev Clin Oncol 2017 Oct;14(10):611-629. Epub 2017 Apr 11 doi: 10.1038/nrclinonc.2017.44. PMID: 28397828Free PMC Article

Prognosis

Pericyte-Glioblastoma Cell Interaction: A Key Target to Prevent Glioblastoma Progression.
Pombero A, Garcia-Lopez R, Martínez S
Cells 2023 May 5;12(9) doi: 10.3390/cells12091324. PMID: 37174724Free PMC Article
The clinical characteristics and treatment of ovarian malignant mesoderm mixed tumor: a systematic review.
Wang X, Wang S, Yao S, Shi W, Ma K
J Ovarian Res 2022 Sep 16;15(1):104. doi: 10.1186/s13048-022-01037-6. PMID: 36114551Free PMC Article
Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS
Nat Commun 2018 May 3;9(1):1777. doi: 10.1038/s41467-018-04179-8. PMID: 29725014Free PMC Article
Brain metastasization of breast cancer.
Custódio-Santos T, Videira M, Brito MA
Biochim Biophys Acta Rev Cancer 2017 Aug;1868(1):132-147. Epub 2017 Mar 21 doi: 10.1016/j.bbcan.2017.03.004. PMID: 28341420
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Clinical prediction guides

Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS
Nat Commun 2018 May 3;9(1):1777. doi: 10.1038/s41467-018-04179-8. PMID: 29725014Free PMC Article
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL
Nature 2017 Jul 27;547(7664):453-457. Epub 2017 Jul 5 doi: 10.1038/nature23007. PMID: 28678785Free PMC Article
Cutaneous/subcutaneous mesenchymal proliferations of the breast.
Orta LY, Beyda JN, Desman GT
Semin Diagn Pathol 2017 Sep;34(5):470-478. Epub 2017 May 30 doi: 10.1053/j.semdp.2017.05.005. PMID: 28662996
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.
Ruze R, Song J, Yin X, Chen Y, Xu R, Wang C, Zhao Y
Signal Transduct Target Ther 2023 Mar 24;8(1):139. doi: 10.1038/s41392-023-01376-w. PMID: 36964133Free PMC Article
MET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review.
Dong Y, Xu J, Sun B, Wang J, Wang Z
Mol Diagn Ther 2022 Mar;26(2):203-227. Epub 2022 Mar 10 doi: 10.1007/s40291-021-00568-w. PMID: 35266116Free PMC Article
Acrometastases to the Hand: A Systematic Review.
Umana GE, Scalia G, Palmisciano P, Passanisi M, Da Ros V, Pompili G, Barone F, Amico P, Tomasi SO, Graziano F, Patti IV, Mele S, Maugeri R, Raffa G, Giammalva GR, Iacopino GD, Germanò A, Nicoletti GF, Ippolito M, Sabini MG, Cicero S, Strigari L, Cuttone G
Medicina (Kaunas) 2021 Sep 9;57(9) doi: 10.3390/medicina57090950. PMID: 34577873Free PMC Article
Esophageal Lipoma and Liposarcoma: A Systematic Review.
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Global epidemiology of gastrointestinal stromal tumours (GIST): A systematic review of population-based cohort studies.
Søreide K, Sandvik OM, Søreide JA, Giljaca V, Jureckova A, Bulusu VR
Cancer Epidemiol 2016 Feb;40:39-46. Epub 2015 Nov 24 doi: 10.1016/j.canep.2015.10.031. PMID: 26618334

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