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Rectal adenosquamous carcinoma

MedGen UID:
313658
•Concept ID:
C1709865
•
Neoplastic Process
Synonyms: rectal adenosquamous cancer; Rectal Adenosquamous Carcinoma; rectal adenosquamous carcinoma
 
Monarch Initiative: MONDO:0056817

Definition

An unusual rectal carcinoma characterized by the presence of glandular and squamous carcinomatous components. The two carcinomatous components may be admixed within the tumor, or the two may appear separately in different areas. [from NCI]

Professional guidelines

PubMed

Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984
Combined external and intracavitary irradiation in treatment of advanced cervical carcinomas: predictive factors for treatment outcome and early and late radiation reactions.
Bohr Mordhorst L, Karlsson L, Bärmark B, Sorbe B
Int J Gynecol Cancer 2014 Sep;24(7):1268-75. doi: 10.1097/IGC.0000000000000208. PMID: 25078336
High-dose-rate intracavitary brachytherapy (HDR-IC) in treatment of cervical carcinoma: 5-year results and implication of increased low-grade rectal complication on initiation of an HDR-IC fractionation scheme.
Wang CJ, Leung SW, Chen HC, Sun LM, Fang FM, Changchien CC, Huang EY, Wu JM, Chen CC
Int J Radiat Oncol Biol Phys 1997 May 1;38(2):391-8. doi: 10.1016/s0360-3016(96)00624-4. PMID: 9226328

Recent clinical studies

Etiology

Characteristics of anal canal cancer in Japan.
Yamada K, Saiki Y, Komori K, Shiomi A, Ueno M, Ito M, Hida K, Yamamoto S, Shiozawa M, Ishihara S, Kanemitsu Y, Ueno H, Kinjo T, Maeda K, Kawamura J, Fujita F, Takahashi K, Mizushima T, Shimada Y, Sasaki S, Sunami E, Ishida F, Hirata K, Ohnuma S, Funahashi K, Watanabe J, Kinugasa Y, Yamaguchi S, Hashiguchi Y, Ikeda M, Sudo T, Komatsu Y, Koda K, Sakamoto K, Okajima M, Ishida H, Hisamatsu Y, Masuda T, Mori S, Minami K, Hasegawa S, Endo S, Iwashita A, Hamada M, Ajioka Y, Usuku K, Ikeda T, Sugihara K
Cancer Med 2022 Jul;11(14):2735-2743. Epub 2022 Mar 10 doi: 10.1002/cam4.4631. PMID: 35274487Free PMC Article
Outcomes analysis of pre-brachytherapy MRI in patients with locally advanced cervical cancer.
Murofushi K, Yoshioka Y, Sumi M, Ishikawa H, Oguchi M, Sakurai H
Int J Gynecol Cancer 2020 Apr;30(4):473-479. Epub 2020 Mar 11 doi: 10.1136/ijgc-2019-000925. PMID: 32165406
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study.
Frizelle FA, Hobday KS, Batts KP, Nelson H
Dis Colon Rectum 2001 Mar;44(3):341-6. doi: 10.1007/BF02234730. PMID: 11289278
Adenosquamous carcinoma of the colon and rectum.
Petrelli NJ, Valle AA, Weber TK, Rodriguez-Bigas M
Dis Colon Rectum 1996 Nov;39(11):1265-8. doi: 10.1007/BF02055120. PMID: 8918436

Diagnosis

Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984
Adenosquamous Cell Carcinoma of the Rectum in a Girl: First Case Reported and Review of the Literature.
García NÁ, Hernando Cubero J, Alonso Orduña V, Torrecilla Idoipe N, Calvo Escribano C, Fernandez Atuán R
J Pediatr Hematol Oncol 2015 Aug;37(6):e364-7. doi: 10.1097/MPH.0000000000000361. PMID: 26181422
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study.
Frizelle FA, Hobday KS, Batts KP, Nelson H
Dis Colon Rectum 2001 Mar;44(3):341-6. doi: 10.1007/BF02234730. PMID: 11289278
Adenosquamous carcinoma of the colon, rectum, and anus: epidemiology, distribution, and survival characteristics.
Cagir B, Nagy MW, Topham A, Rakinic J, Fry RD
Dis Colon Rectum 1999 Feb;42(2):258-63. doi: 10.1007/BF02237138. PMID: 10211505

Therapy

Outcomes analysis of pre-brachytherapy MRI in patients with locally advanced cervical cancer.
Murofushi K, Yoshioka Y, Sumi M, Ishikawa H, Oguchi M, Sakurai H
Int J Gynecol Cancer 2020 Apr;30(4):473-479. Epub 2020 Mar 11 doi: 10.1136/ijgc-2019-000925. PMID: 32165406
External Beam Radiation Therapy and Brachytherapy for Cervical Cancer: The Experience of the National Centre for Radiotherapy in Accra, Ghana.
Vulpe H, Asamoah FA, Maganti M, Vanderpuye V, Fyles A, Yarney J
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1246-1253. Epub 2017 Dec 21 doi: 10.1016/j.ijrobp.2017.12.270. PMID: 29395628
Toxicities and dose-volume histogram parameters of MRI-based brachytherapy for cervical cancer.
Kim Y, Kim YJ, Kim JY, Lim YK, Jeong C, Jeong J, Kim M, Lim MC, Seo SS, Park SY
Brachytherapy 2017 Jan-Feb;16(1):116-125. Epub 2016 Nov 18 doi: 10.1016/j.brachy.2016.10.005. PMID: 27876378
Adenosquamous Cell Carcinoma of the Rectum in a Girl: First Case Reported and Review of the Literature.
García NÁ, Hernando Cubero J, Alonso Orduña V, Torrecilla Idoipe N, Calvo Escribano C, Fernandez Atuán R
J Pediatr Hematol Oncol 2015 Aug;37(6):e364-7. doi: 10.1097/MPH.0000000000000361. PMID: 26181422
Evaluation of external beam therapy and three brachytherapy fractions for carcinoma of the uterine cervix.
Mitsuhashi N, Takahashi M, Nozaki M, Yamakawa M, Takahashi T, Sakurai H, Hayakawa K, Niibe H
Int J Radiat Oncol Biol Phys 1994 Jul 30;29(5):975-82. doi: 10.1016/0360-3016(94)90391-3. PMID: 8083099

Prognosis

Characteristics of anal canal cancer in Japan.
Yamada K, Saiki Y, Komori K, Shiomi A, Ueno M, Ito M, Hida K, Yamamoto S, Shiozawa M, Ishihara S, Kanemitsu Y, Ueno H, Kinjo T, Maeda K, Kawamura J, Fujita F, Takahashi K, Mizushima T, Shimada Y, Sasaki S, Sunami E, Ishida F, Hirata K, Ohnuma S, Funahashi K, Watanabe J, Kinugasa Y, Yamaguchi S, Hashiguchi Y, Ikeda M, Sudo T, Komatsu Y, Koda K, Sakamoto K, Okajima M, Ishida H, Hisamatsu Y, Masuda T, Mori S, Minami K, Hasegawa S, Endo S, Iwashita A, Hamada M, Ajioka Y, Usuku K, Ikeda T, Sugihara K
Cancer Med 2022 Jul;11(14):2735-2743. Epub 2022 Mar 10 doi: 10.1002/cam4.4631. PMID: 35274487Free PMC Article
Presentation, treatment, and prognosis of colorectal adenosquamous carcinoma: A contemporary analysis of the surveillance, epidemiology, and end results database.
Khan AH, Gao X, Goffredo P, Kahl AR, Utria AF, Charlton ME, Ahad S, Hassan I
Am J Surg 2022 May;223(5):957-962. Epub 2021 Sep 11 doi: 10.1016/j.amjsurg.2021.09.004. PMID: 34530984
Population-based evaluation of adenosquamous carcinoma of the colon and rectum.
Masoomi H, Ziogas A, Lin BS, Barleben A, Mills S, Stamos MJ, Zell JA
Dis Colon Rectum 2012 May;55(5):509-14. doi: 10.1097/DCR.0b013e3182420953. PMID: 22513428Free PMC Article
Adenosquamous and squamous carcinoma of the colon and upper rectum: a clinical and histopathologic study.
Frizelle FA, Hobday KS, Batts KP, Nelson H
Dis Colon Rectum 2001 Mar;44(3):341-6. doi: 10.1007/BF02234730. PMID: 11289278
Adenosquamous carcinoma of the colon, rectum, and anus: epidemiology, distribution, and survival characteristics.
Cagir B, Nagy MW, Topham A, Rakinic J, Fry RD
Dis Colon Rectum 1999 Feb;42(2):258-63. doi: 10.1007/BF02237138. PMID: 10211505

Clinical prediction guides

Colonic adenosquamous carcinoma and mucinous adenocarcinoma with microsatellite instability.
Parra-Medina R, Lopez-Correa P, Gutierrez V, Polo F
Malays J Pathol 2018 Aug;40(2):199-202. PMID: 30173239
Toxicities and dose-volume histogram parameters of MRI-based brachytherapy for cervical cancer.
Kim Y, Kim YJ, Kim JY, Lim YK, Jeong C, Jeong J, Kim M, Lim MC, Seo SS, Park SY
Brachytherapy 2017 Jan-Feb;16(1):116-125. Epub 2016 Nov 18 doi: 10.1016/j.brachy.2016.10.005. PMID: 27876378
Adenosquamous Cell Carcinoma of the Rectum in a Girl: First Case Reported and Review of the Literature.
García NÁ, Hernando Cubero J, Alonso Orduña V, Torrecilla Idoipe N, Calvo Escribano C, Fernandez Atuán R
J Pediatr Hematol Oncol 2015 Aug;37(6):e364-7. doi: 10.1097/MPH.0000000000000361. PMID: 26181422
Combined external and intracavitary irradiation in treatment of advanced cervical carcinomas: predictive factors for treatment outcome and early and late radiation reactions.
Bohr Mordhorst L, Karlsson L, Bärmark B, Sorbe B
Int J Gynecol Cancer 2014 Sep;24(7):1268-75. doi: 10.1097/IGC.0000000000000208. PMID: 25078336
Treatment of cervical carcinoma with high-dose rate intracavitary brachytherapy: two years follow-up study.
Das D, Chaudhuri S, Deb AR, Aich RK, Gangopadhyay S, Ray A
Asian Pac J Cancer Prev 2011;12(3):807-10. PMID: 21627388

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