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Lung pleomorphic carcinoma

MedGen UID:
314017
•Concept ID:
C1711397
•
Neoplastic Process
Synonyms: Lung Pleomorphic Carcinoma; lung pleomorphic carcinoma; Pleomorphic carcinoma of lung
SNOMED CT: Pleomorphic carcinoma of lung (1255641009)
 
Monarch Initiative: MONDO:0850345

Definition

A morphologic variant of sarcomatoid carcinoma characterized by the presence of malignant glandular or squamous cells associated with malignant giant and spindle cells. [from NCI]

Professional guidelines

PubMed

SMARCA4 as a support for the differential diagnosis of poorly differentiated lung carcinomas.
Panozzi M, Alì G, Proietti A, Melfi F, Zirafa CC, Lucchi M, Fontanini G
Pathologica 2023 Jun;115(3):164-171. doi: 10.32074/1591-951X-847. PMID: 37387441Free PMC Article
Dedifferentiated and Undifferentiated Melanomas: Report of 35 New Cases With Literature Review and Proposal of Diagnostic Criteria.
Agaimy A, Stoehr R, Hornung A, Popp J, Erdmann M, Heinzerling L, Hartmann A
Am J Surg Pathol 2021 Feb 1;45(2):240-254. doi: 10.1097/PAS.0000000000001645. PMID: 33428337
Micropapillary adenocarcinoma of lung: Morphological criteria and diagnostic reproducibility among pulmonary pathologists.
Monroig-Bosque PDC, Morales-Rosado JA, Roden AC, Churg A, Barrios R, Cagle P, Ge Y, Allen TC, Smith ML, Larsen BT, Sholl LM, Beasley MB, Borczuk A, Raparia K, Ayala A, Tazelaar HD, Miller R, Kalhor N, Moran CA, Ro JY
Ann Diagn Pathol 2019 Aug;41:43-50. Epub 2019 Apr 24 doi: 10.1016/j.anndiagpath.2019.04.008. PMID: 31132651

Recent clinical studies

Etiology

Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Chen D, Mao Y, Wen J, She Y, Zhu E, Zhu F, Zhang Y, Fan M, Chen C, Chen Y
Ann Thorac Surg 2019 Sep;108(3):945-954. Epub 2019 Mar 23 doi: 10.1016/j.athoracsur.2019.02.045. PMID: 30914285
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma.
Yokoyama S, Murakami T, Tao H, Onoda H, Hara A, Miyazaki R, Furukawa M, Hayashi M, Inokawa H, Okabe K, Akagi Y
Chest 2018 Oct;154(4):838-847. Epub 2018 Jun 19 doi: 10.1016/j.chest.2018.06.007. PMID: 29932891

Diagnosis

Argon plasma coagulation with atezolizumab and chemoradiation in lung pleomorphic cancer showed a remarkable response: Case report.
Harada M, Morikawa K, Kagoo N, Ito Y, Kubota T, Ichijo K, Mochizuki E, Uehara M, Matsuura S, Yasuda K, Tsukui M, Koshimizu N
Medicine (Baltimore) 2021 May 28;100(21):e26149. doi: 10.1097/MD.0000000000026149. PMID: 34032770Free PMC Article
Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.
Tamiya A, Asami K, Shimizu S, Matsumura A, Isa S, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A
Intern Med 2014;53(22):2625-8. Epub 2014 Nov 15 doi: 10.2169/internalmedicine.53.2637. PMID: 25400187
Intussusception caused by intestinal metastasis from lung pleomorphic carcinoma.
Lin MW, Wu CT, Chang YL
Ann Thorac Cardiovasc Surg 2014;20 Suppl:635-8. Epub 2013 Jul 31 doi: 10.5761/atcs.cr.13-00099. PMID: 23903709
Pleomorphic carcinoma of the lung arising in a patient with Li-Fraumeni syndrome: report of a case.
Kato T, Ishikawa K, Satoh M, Kondo S, Kaji M
Surg Today 2011 Jun;41(6):841-5. Epub 2011 May 28 doi: 10.1007/s00595-010-4359-0. PMID: 21626334

Therapy

Argon plasma coagulation with atezolizumab and chemoradiation in lung pleomorphic cancer showed a remarkable response: Case report.
Harada M, Morikawa K, Kagoo N, Ito Y, Kubota T, Ichijo K, Mochizuki E, Uehara M, Matsuura S, Yasuda K, Tsukui M, Koshimizu N
Medicine (Baltimore) 2021 May 28;100(21):e26149. doi: 10.1097/MD.0000000000026149. PMID: 34032770Free PMC Article
Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.
Tamiya A, Asami K, Shimizu S, Matsumura A, Isa S, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A
Intern Med 2014;53(22):2625-8. Epub 2014 Nov 15 doi: 10.2169/internalmedicine.53.2637. PMID: 25400187

Prognosis

Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Chen D, Mao Y, Wen J, She Y, Zhu E, Zhu F, Zhang Y, Fan M, Chen C, Chen Y
Ann Thorac Surg 2019 Sep;108(3):945-954. Epub 2019 Mar 23 doi: 10.1016/j.athoracsur.2019.02.045. PMID: 30914285
Spread Through Air Spaces (STAS): A New Pathologic Morphology in Lung Cancer.
Ma K, Zhan C, Wang S, Shi Y, Jiang W, Wang Q
Clin Lung Cancer 2019 Mar;20(2):e158-e162. Epub 2018 Oct 26 doi: 10.1016/j.cllc.2018.10.007. PMID: 30482593
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma.
Yokoyama S, Murakami T, Tao H, Onoda H, Hara A, Miyazaki R, Furukawa M, Hayashi M, Inokawa H, Okabe K, Akagi Y
Chest 2018 Oct;154(4):838-847. Epub 2018 Jun 19 doi: 10.1016/j.chest.2018.06.007. PMID: 29932891
Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.
Tamiya A, Asami K, Shimizu S, Matsumura A, Isa S, Okishio K, Kitaichi M, Atagi S, Takada M, Kawaguchi T, Kubo A
Intern Med 2014;53(22):2625-8. Epub 2014 Nov 15 doi: 10.2169/internalmedicine.53.2637. PMID: 25400187
Intussusception caused by intestinal metastasis from lung pleomorphic carcinoma.
Lin MW, Wu CT, Chang YL
Ann Thorac Cardiovasc Surg 2014;20 Suppl:635-8. Epub 2013 Jul 31 doi: 10.5761/atcs.cr.13-00099. PMID: 23903709

Clinical prediction guides

Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Chen D, Mao Y, Wen J, She Y, Zhu E, Zhu F, Zhang Y, Fan M, Chen C, Chen Y
Ann Thorac Surg 2019 Sep;108(3):945-954. Epub 2019 Mar 23 doi: 10.1016/j.athoracsur.2019.02.045. PMID: 30914285
Tumor Spread Through Air Spaces Identifies a Distinct Subgroup With Poor Prognosis in Surgically Resected Lung Pleomorphic Carcinoma.
Yokoyama S, Murakami T, Tao H, Onoda H, Hara A, Miyazaki R, Furukawa M, Hayashi M, Inokawa H, Okabe K, Akagi Y
Chest 2018 Oct;154(4):838-847. Epub 2018 Jun 19 doi: 10.1016/j.chest.2018.06.007. PMID: 29932891

Recent systematic reviews

Tumor Spread Through Air Spaces in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
Chen D, Mao Y, Wen J, She Y, Zhu E, Zhu F, Zhang Y, Fan M, Chen C, Chen Y
Ann Thorac Surg 2019 Sep;108(3):945-954. Epub 2019 Mar 23 doi: 10.1016/j.athoracsur.2019.02.045. PMID: 30914285

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