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Cellular Myxoma

MedGen UID:
317498
•Concept ID:
C1707332
•
Neoplastic Process

Definition

An intramuscular myxoma with increased cellularity and increased numbers of collagen fibers and blood vessels. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCellular Myxoma

Professional guidelines

PubMed

Advances in viral oncolytics for treatment of multiple myeloma - a focused review.
Sarwar A, Hashim L, Faisal MS, Haider MZ, Ahmed Z, Ahmed TF, Shahzad M, Ansar I, Ali S, Aslam MM, Anwer F
Expert Rev Hematol 2021 Dec;14(12):1071-1083. Epub 2021 Sep 15 doi: 10.1080/17474086.2021.1972802. PMID: 34428997
Differential Diagnosis of Benign Spindle Cell Lesions.
Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661
Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues.
Layfield LJ
Diagn Cytopathol 2003 May;28(5):264-71. doi: 10.1002/dc.10281. PMID: 12722122

Recent clinical studies

Etiology

Cellular Myxoma of the Vocal Cord: A Case Report and Review of the Literature.
Val-Bernal JF, Martino M, Longarela MY
Turk Patoloji Derg 2020;36(1):77-81. doi: 10.5146/tjpath.2017.01417. PMID: 29235612Free PMC Article
Fine-needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics.
Yang EJ, Hornick JL, Qian X
Cancer Cytopathol 2016 Sep;124(9):651-8. Epub 2016 May 9 doi: 10.1002/cncy.21725. PMID: 27159449
Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301
Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation.
Dawamneh MF, Amra NK, Amr SS
Acta Cytol 2006 Mar-Apr;50(2):208-12. doi: 10.1159/000325934. PMID: 16610692
Cellular myxoma of soft tissue: a clinicopathological study of 38 cases confirming indolent clinical behaviour.
van Roggen JF, McMenamin ME, Fletcher CD
Histopathology 2001 Sep;39(3):287-97. doi: 10.1046/j.1365-2559.2001.01209.x. PMID: 11532040

Diagnosis

The Role of Methylation Analysis in Distinguishing Cellular Myxoma from Low-Grade Myxofibrosarcoma.
Henzinger H, Brčić I, Igrec J, Godschachner TM, Scheipl S, Szkandera J, Jurmeister P, Liegl-Atzwanger B
Int J Mol Sci 2024 May 8;25(10) doi: 10.3390/ijms25105105. PMID: 38791144Free PMC Article
CYP1A1 immunohistochemistry is highly specific for angiofibroma of soft tissue among morphological mimics.
Bauer AH, Fletcher CDM, Hornick JL, Papke DJ Jr
Histopathology 2024 Jan;84(2):381-386. Epub 2023 Oct 19 doi: 10.1111/his.15070. PMID: 37855220
Cellular Myxoma of the Vocal Cord: A Case Report and Review of the Literature.
Val-Bernal JF, Martino M, Longarela MY
Turk Patoloji Derg 2020;36(1):77-81. doi: 10.5146/tjpath.2017.01417. PMID: 29235612Free PMC Article
Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors.
Sunitsch S, Gilg MM, Kashofer K, Gollowitsch F, Leithner A, Liegl-Atzwanger B
Diagn Pathol 2018 Aug 15;13(1):52. doi: 10.1186/s13000-018-0734-8. PMID: 30111377Free PMC Article
Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix.
Willems SM, Mohseny AB, Balog C, Sewrajsing R, Briaire-de Bruijn IH, Knijnenburg J, Cleton-Jansen AM, Sciot R, Fletcher CD, Deelder AM, Szuhai K, Hensbergen PJ, Hogendoorn PC
J Cell Mol Med 2009 Jul;13(7):1291-301. Epub 2009 Mar 13 doi: 10.1111/j.1582-4934.2009.00747.x. PMID: 19320777Free PMC Article

Therapy

Digital fibromyxoma (superficial acral fibromyxoma): a detailed characterization of 124 cases.
Hollmann TJ, Bovée JV, Fletcher CD
Am J Surg Pathol 2012 Jun;36(6):789-98. doi: 10.1097/PAS.0b013e31824a0b83. PMID: 22367301

Prognosis

The Role of Methylation Analysis in Distinguishing Cellular Myxoma from Low-Grade Myxofibrosarcoma.
Henzinger H, Brčić I, Igrec J, Godschachner TM, Scheipl S, Szkandera J, Jurmeister P, Liegl-Atzwanger B
Int J Mol Sci 2024 May 8;25(10) doi: 10.3390/ijms25105105. PMID: 38791144Free PMC Article
Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors.
Sunitsch S, Gilg MM, Kashofer K, Gollowitsch F, Leithner A, Liegl-Atzwanger B
Diagn Pathol 2018 Aug 15;13(1):52. doi: 10.1186/s13000-018-0734-8. PMID: 30111377Free PMC Article
Fine-needle aspiration of soft tissue perineurioma: A comparative analysis of cytomorphology and immunohistochemistry with benign and malignant mimics.
Yang EJ, Hornick JL, Qian X
Cancer Cytopathol 2016 Sep;124(9):651-8. Epub 2016 May 9 doi: 10.1002/cncy.21725. PMID: 27159449
Juxta-articular myxoma: an unusual benign mesenchymal lesion, readily mistaken for malignancy.
Beggan C, Davies K, Leader M
Ir Med J 2014 Jul-Aug;107(7):212-3. PMID: 25226717
Low grade fibromyxoid sarcoma: report of a case with fine needle aspiration cytology and histologic correlation.
Dawamneh MF, Amra NK, Amr SS
Acta Cytol 2006 Mar-Apr;50(2):208-12. doi: 10.1159/000325934. PMID: 16610692

Clinical prediction guides

The Role of Methylation Analysis in Distinguishing Cellular Myxoma from Low-Grade Myxofibrosarcoma.
Henzinger H, Brčić I, Igrec J, Godschachner TM, Scheipl S, Szkandera J, Jurmeister P, Liegl-Atzwanger B
Int J Mol Sci 2024 May 8;25(10) doi: 10.3390/ijms25105105. PMID: 38791144Free PMC Article
Detection of GNAS mutations in intramuscular / cellular myxomas as diagnostic tool in the classification of myxoid soft tissue tumors.
Sunitsch S, Gilg MM, Kashofer K, Gollowitsch F, Leithner A, Liegl-Atzwanger B
Diagn Pathol 2018 Aug 15;13(1):52. doi: 10.1186/s13000-018-0734-8. PMID: 30111377Free PMC Article

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