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Large cell lung carcinoma, clear cell variant

MedGen UID:
317518
•Concept ID:
C1707407
•
Neoplastic Process
Synonyms: Clear Cell Carcinoma of Lung, Large Cell Type; clear cell carcinoma of lung, large cell type; clear cell carcinoma of the lung; Clear Cell Carcinoma of the Lung, Large Cell Type; clear cell carcinoma of the lung, large cell type; Clear Cell Lung Carcinoma, Large Cell Type; clear cell lung carcinoma, large cell type; Large Cell Lung Carcinoma, Clear Cell Variant; large cell lung carcinoma, clear cell variant; Lung Large Cell Carcinoma, Clear Cell Variant
 
Monarch Initiative: MONDO:0024386

Definition

A large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen. [from NCI]

Professional guidelines

PubMed

Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non-small cell lung cancer: A large real-world cohort and review of the literature.
Averbuch I, Tschernichovsky R, Icht O, Goldstein DA, Mutai R, Dudnik E, Rotem O, Peled N, Allen AM, Laufer-Geva S, Goldberg Y, Zer A
Thorac Cancer 2023 Jun;14(17):1589-1596. Epub 2023 Apr 24 doi: 10.1111/1759-7714.14902. PMID: 37095004Free PMC Article

Recent clinical studies

Etiology

Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non-small cell lung cancer: A large real-world cohort and review of the literature.
Averbuch I, Tschernichovsky R, Icht O, Goldstein DA, Mutai R, Dudnik E, Rotem O, Peled N, Allen AM, Laufer-Geva S, Goldberg Y, Zer A
Thorac Cancer 2023 Jun;14(17):1589-1596. Epub 2023 Apr 24 doi: 10.1111/1759-7714.14902. PMID: 37095004Free PMC Article
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
Boukakis G, Patrinou-Georgoula M, Lekarakou M, Valavanis C, Guialis A
BMC Cancer 2010 Aug 17;10:434. doi: 10.1186/1471-2407-10-434. PMID: 20716340Free PMC Article
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Large cell carcinoma of the lung.
Yesner R
Semin Diagn Pathol 1985 Nov;2(4):255-69. PMID: 3039629

Diagnosis

Recent developments in the pathology of primary pulmonary salivary gland-type tumours.
Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non-small cell lung cancer: A large real-world cohort and review of the literature.
Averbuch I, Tschernichovsky R, Icht O, Goldstein DA, Mutai R, Dudnik E, Rotem O, Peled N, Allen AM, Laufer-Geva S, Goldberg Y, Zer A
Thorac Cancer 2023 Jun;14(17):1589-1596. Epub 2023 Apr 24 doi: 10.1111/1759-7714.14902. PMID: 37095004Free PMC Article
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.
Ferrara R, Auger N, Auclin E, Besse B
J Thorac Oncol 2018 Jan;13(1):27-45. Epub 2017 Nov 8 doi: 10.1016/j.jtho.2017.10.021. PMID: 29128428
The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification.
Travis WD, Brambilla E, Nicholson AG, Yatabe Y, Austin JHM, Beasley MB, Chirieac LR, Dacic S, Duhig E, Flieder DB, Geisinger K, Hirsch FR, Ishikawa Y, Kerr KM, Noguchi M, Pelosi G, Powell CA, Tsao MS, Wistuba I; WHO Panel
J Thorac Oncol 2015 Sep;10(9):1243-1260. doi: 10.1097/JTO.0000000000000630. PMID: 26291008
Large cell carcinoma of the lung.
Yesner R
Semin Diagn Pathol 1985 Nov;2(4):255-69. PMID: 3039629

Therapy

Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
van Eijk M, Pluim D, Dorlo TPC, Marchetti S, Huitema ADR, Beijnen JH
Pharmacogenomics J 2021 Jun;21(3):336-345. Epub 2021 Mar 1 doi: 10.1038/s41397-021-00213-z. PMID: 33649517
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.
Ferrara R, Auger N, Auclin E, Besse B
J Thorac Oncol 2018 Jan;13(1):27-45. Epub 2017 Nov 8 doi: 10.1016/j.jtho.2017.10.021. PMID: 29128428
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
Boukakis G, Patrinou-Georgoula M, Lekarakou M, Valavanis C, Guialis A
BMC Cancer 2010 Aug 17;10:434. doi: 10.1186/1471-2407-10-434. PMID: 20716340Free PMC Article
Secreted form of EphA7 in lung cancer.
Tsuboi M, Mori H, Bunai T, Kageyama S, Suzuki M, Okudela K, Takamochi K, Ogawa H, Niwa H, Shinmura K, Sugimura H
Int J Oncol 2010 Mar;36(3):635-40. PMID: 20126984
Pathogenesis and pathology.
Yesner R
Clin Chest Med 1993 Mar;14(1):17-30. PMID: 8384961

Prognosis

Recent developments in the pathology of primary pulmonary salivary gland-type tumours.
Naso JR, Roden AC
Histopathology 2024 Jan;84(1):102-123. Epub 2023 Sep 11 doi: 10.1111/his.15039. PMID: 37694812
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
Turajlic S, Litchfield K, Xu H, Rosenthal R, McGranahan N, Reading JL, Wong YNS, Rowan A, Kanu N, Al Bakir M, Chambers T, Salgado R, Savas P, Loi S, Birkbak NJ, Sansregret L, Gore M, Larkin J, Quezada SA, Swanton C
Lancet Oncol 2017 Aug;18(8):1009-1021. Epub 2017 Jul 7 doi: 10.1016/S1470-2045(17)30516-8. PMID: 28694034
Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.
Boukakis G, Patrinou-Georgoula M, Lekarakou M, Valavanis C, Guialis A
BMC Cancer 2010 Aug 17;10:434. doi: 10.1186/1471-2407-10-434. PMID: 20716340Free PMC Article
A comparative study of metastatic renal cell carcinoma with correlation to subtype and primary tumor.
Mai KT, Landry DC, Robertson SJ, Commons AS, Burns BF, Thijssen A, Collins J
Pathol Res Pract 2001;197(10):671-5. doi: 10.1078/0344-0338-00144. PMID: 11700888
Aggressive variants of chromophobe renal cell carcinoma.
Renshaw AA, Henske EP, Loughlin KR, Shapiro C, Weinberg DS
Cancer 1996 Oct 15;78(8):1756-61. doi: 10.1002/(sici)1097-0142(19961015)78:8<1756::aid-cncr16>3.0.co;2-x. PMID: 8859189

Clinical prediction guides

Investigating the influence of relevant pharmacogenetic variants on the pharmacokinetics and pharmacodynamics of orally administered docetaxel combined with ritonavir.
van Eijk M, Pluim D, Dorlo TPC, Marchetti S, Huitema ADR, Beijnen JH
Pharmacogenomics J 2021 Jun;21(3):336-345. Epub 2021 Mar 1 doi: 10.1038/s41397-021-00213-z. PMID: 33649517
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis.
Turajlic S, Litchfield K, Xu H, Rosenthal R, McGranahan N, Reading JL, Wong YNS, Rowan A, Kanu N, Al Bakir M, Chambers T, Salgado R, Savas P, Loi S, Birkbak NJ, Sansregret L, Gore M, Larkin J, Quezada SA, Swanton C
Lancet Oncol 2017 Aug;18(8):1009-1021. Epub 2017 Jul 7 doi: 10.1016/S1470-2045(17)30516-8. PMID: 28694034
High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases.
Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, Asamura H, Nakajima J, Takai D, Mori M, Oka T, Tamaru J, Itoyama S, Furuta K, Fukayama M, Tsuda H
Am J Surg Pathol 2013 Jun;37(6):924-32. doi: 10.1097/PAS.0b013e31827e1e83. PMID: 23629442

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