U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Low Grade Myofibroblastic Sarcoma

MedGen UID:
317844
•Concept ID:
C1708751
•
Neoplastic Process
Synonyms: Low grade myofibroblastic sarcoma; Low-Grade Myofibroblastic Sarcoma; Myofibroblastic Sarcoma; Myofibrosarcoma
SNOMED CT: Low grade myofibroblastic sarcoma (703615007)

Definition

A low-grade malignant neoplasm arising from the soft tissue and rarely bone. It is characterized by the presence of spindle-shaped myofibroblasts and collagenous stroma formation in a storiform growth pattern. Metastasis is very rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLow Grade Myofibroblastic Sarcoma

Professional guidelines

PubMed

Is there a role for chemotherapy and radiation in the treatment of patients with low-grade myofibroblastic sarcoma?
Xu Y, Xu G, Wang X, Mao M, Wu H, Baklaushev VP, Chekhonin VP, Peltzer K, Wang G, Zhang C
Clin Transl Oncol 2021 Feb;23(2):344-352. Epub 2020 Jun 30 doi: 10.1007/s12094-020-02425-4. PMID: 32607812

Recent clinical studies

Etiology

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
An update on selected cutaneous (myo) fibroblastic mesenchymal tumors.
Georgantzoglou N, Linos K
Semin Diagn Pathol 2023 Jul;40(4):295-305. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.018. PMID: 37150655Free PMC Article
Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck.
Baranov E, Hornick JL
Head Neck Pathol 2020 Mar;14(1):43-58. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01104-3. PMID: 31950474Free PMC Article
Low-grade myofibroblastic sarcoma of the orbit: A case report and literature review.
Zhang S, Ma Y, Ma T, Wang Z
Medicine (Baltimore) 2017 Dec;96(51):e9172. doi: 10.1097/MD.0000000000009172. PMID: 29390454Free PMC Article
Low-grade myofibroblastic sarcoma: A population-based study.
Chan JY, Gooi Z, Wong EW, Ng SK, Tong MC, Vlantis AC
Laryngoscope 2017 Jan;127(1):116-121. Epub 2016 Jul 5 doi: 10.1002/lary.26146. PMID: 27377169

Diagnosis

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
An update on selected cutaneous (myo) fibroblastic mesenchymal tumors.
Georgantzoglou N, Linos K
Semin Diagn Pathol 2023 Jul;40(4):295-305. Epub 2023 Apr 25 doi: 10.1053/j.semdp.2023.04.018. PMID: 37150655Free PMC Article
Low-grade myofibroblastic sarcoma of the liver misdiagnosed as cystadenoma: A case report.
Li J, Huang XY, Zhang B
World J Gastroenterol 2022 Aug 21;28(31):4456-4462. doi: 10.3748/wjg.v28.i31.4456. PMID: 36159015Free PMC Article
Low-grade Myofibroblastic sarcoma: clinical and imaging findings.
Wang L, Li LX, Chen DQ, Yang L, Li SK, Cheng C
BMC Med Imaging 2019 May 2;19(1):36. doi: 10.1186/s12880-018-0287-z. PMID: 31046697Free PMC Article
Low-grade myofibroblastic sarcoma: A population-based study.
Chan JY, Gooi Z, Wong EW, Ng SK, Tong MC, Vlantis AC
Laryngoscope 2017 Jan;127(1):116-121. Epub 2016 Jul 5 doi: 10.1002/lary.26146. PMID: 27377169

Therapy

Myofibrosarcoma (low-grade myofibroblastic sarcoma) with intracytoplasmic hyaline (fibroma-like) inclusion bodies.
González-Cámpora R, Escudero AG, Ríos Martín JJ, Armas Padrón JR, Vázquez AH, Vázquez Ramírez FJ
Ultrastruct Pathol 2003 Jan-Feb;27(1):7-11. doi: 10.1080/01913120309942. PMID: 12554531

Prognosis

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Surgical treatment and long-term outcomes of low-grade myofibroblastic sarcoma: a single-center case series of 15 patients.
Kim JH, Choi W, Cho HS, Lee KS, Park JK, Kim BK
World J Surg Oncol 2021 Dec 7;19(1):339. doi: 10.1186/s12957-021-02454-5. PMID: 34872570Free PMC Article
Low-grade myofibroblastic sarcoma of the orbit: A case report and literature review.
Zhang S, Ma Y, Ma T, Wang Z
Medicine (Baltimore) 2017 Dec;96(51):e9172. doi: 10.1097/MD.0000000000009172. PMID: 29390454Free PMC Article
Low-grade myofibroblastic sarcoma: A population-based study.
Chan JY, Gooi Z, Wong EW, Ng SK, Tong MC, Vlantis AC
Laryngoscope 2017 Jan;127(1):116-121. Epub 2016 Jul 5 doi: 10.1002/lary.26146. PMID: 27377169
Pediatric Fibroblastic and Myofibroblastic Tumors: A Pictorial Review.
Sargar KM, Sheybani EF, Shenoy A, Aranake-Chrisinger J, Khanna G
Radiographics 2016 Jul-Aug;36(4):1195-214. doi: 10.1148/rg.2016150191. PMID: 27399243

Clinical prediction guides

Fibroblastic and Myofibroblastic Soft-Tissue Tumors: Imaging Spectrum and Radiologic-Pathologic Correlation.
Haseli S, Mansoori B, Christensen D, Abadi A, Pooyan A, Shomal Zadeh F, Mau B, Khalili N, Murphey M, Chalian M
Radiographics 2023 Aug;43(8):e230005. doi: 10.1148/rg.230005. PMID: 37440448
Low-grade myofibroblastic sarcoma of the proximal femur: A case report and literature review.
Gao G, Liu Y, Ao Y, Wang J, Xu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31715. doi: 10.1097/MD.0000000000031715. PMID: 36397412Free PMC Article
Low-grade Myofibroblastic sarcoma: clinical and imaging findings.
Wang L, Li LX, Chen DQ, Yang L, Li SK, Cheng C
BMC Med Imaging 2019 May 2;19(1):36. doi: 10.1186/s12880-018-0287-z. PMID: 31046697Free PMC Article
Low-grade myofibroblastic sarcoma of the orbit: A case report and literature review.
Zhang S, Ma Y, Ma T, Wang Z
Medicine (Baltimore) 2017 Dec;96(51):e9172. doi: 10.1097/MD.0000000000009172. PMID: 29390454Free PMC Article
Low-grade myofibroblastic sarcoma of the palate.
Yamada T, Yoshimura T, Kitamura N, Sasabe E, Ohno S, Yamamoto T
Int J Oral Sci 2012 Sep;4(3):170-3. Epub 2012 Aug 31 doi: 10.1038/ijos.2012.49. PMID: 22935748Free PMC Article

Recent systematic reviews

Risk Factors for Recurrence and the Role of Radiotherapy in Low-grade Myofibroblastic Sarcoma: A Systematic Review.
Mamikunian G, Ziegler A, Block A, Thorpe E
Am J Clin Oncol 2023 Sep 1;46(9):420-425. Epub 2023 Jun 26 doi: 10.1097/COC.0000000000001025. PMID: 37358303

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...