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Lung Atypical Carcinoid Tumor

MedGen UID:: 317846
•Concept ID:: C1708766
•: Neoplastic Process

Synonyms:	Lung NET G2; Lung NET Grade 2; Lung NET, Grade 2; Lung Neuroendocrine Tumor G2; Lung Neuroendocrine Tumor Grade 2; Lung Neuroendocrine Tumor, Grade 2; Malignant carcinoid tumor of lung
SNOMED CT:	Malignant carcinoid tumor of lung (123661000119106)

Definition

A carcinoid tumor of the lung showing focal necrotic changes or a number of mitotic figures between 2 and 10/10 high power fields. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLung Atypical Carcinoid Tumor

Atypical carcinoid tumor
- Lung Atypical Carcinoid Tumor

Professional guidelines

PubMed

Diagnosis and management of typical and atypical lung carcinoids.

Pusceddu S, Lo Russo G, Macerelli M, Proto C, Vitali M, Signorelli D, Ganzinelli M, Scanagatta P, Duranti L, Trama A, Buzzoni R, Pelosi G, Pastorino U, de Braud F, Garassino MC
Crit Rev Oncol Hematol 2016 Apr;100:167-76. Epub 2016 Feb 18 doi: 10.1016/j.critrevonc.2016.02.009. PMID: 26917456

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.

Caplin ME, Baudin E, Ferolla P, Filosso P, Garcia-Yuste M, Lim E, Oberg K, Pelosi G, Perren A, Rossi RE, Travis WD; ENETS consensus conference participants
Ann Oncol 2015 Aug;26(8):1604-20. Epub 2015 Feb 2 doi: 10.1093/annonc/mdv041. PMID: 25646366

Diagnosis and treatment of neuroendocrine lung tumors.

Sánchez de Cos Escuín J
Arch Bronconeumol 2014 Sep;50(9):392-6. Epub 2014 Mar 28 doi: 10.1016/j.arbres.2014.02.004. PMID: 24685201

See all (55)

Recent clinical studies

Etiology

Carcinoid tumors outside the abdomen.

Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885 Free PMC Article

Lung carcinoid tumours: histology and Ki-67, the eternal rivalry.

Centonze G, Maisonneuve P, Simbolo M, Lagano V, Grillo F, Fabbri A, Prinzi N, Garzone G, Filugelli M, Pardo C, Mietta A, Pusceddu S, Sabella G, Bercich L, Mangogna A, Rolli L, Grisanti S, Benvenuti MR, Pastorino U, Roz L, Scarpa A, Berruti A, Capella C, Milione M
Histopathology 2023 Jan;82(2):324-339. Epub 2022 Oct 26 doi: 10.1111/his.14819. PMID: 36239545 Free PMC Article

Small-Cell Carcinoma of the Lung: What We Learned about It?

Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591

Pulmonary Neuroendocrine Tumors.

Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434

Advanced typical and atypical carcinoid tumours of the lung: management recommendations.

Melosky B
Curr Oncol 2018 Jun;25(Suppl 1):S86-S93. Epub 2018 Jun 13 doi: 10.3747/co.25.3808. PMID: 29910651 Free PMC Article

See all (323)

Diagnosis

Carcinoid tumors outside the abdomen.

Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885 Free PMC Article

Small-Cell Carcinoma of the Lung: What We Learned about It?

Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591

Pulmonary Neuroendocrine Tumors.

Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434

Diagnosis and management of typical and atypical lung carcinoids.

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.

See all (431)

Therapy

Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?

Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210

Peptide Receptor Radionuclide Therapy for Patients With Advanced Lung Carcinoids.

Naraev BG, Ramirez RA, Kendi AT, Halfdanarson TR
Clin Lung Cancer 2019 May;20(3):e376-e392. Epub 2019 Mar 1 doi: 10.1016/j.cllc.2019.02.007. PMID: 30910575

Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.

Robelin P, Hadoux J, Forestier J, Planchard D, Hervieu V, Berdelou A, Scoazec JY, Valette PJ, Leboulleux S, Ducreux M, Lombard-Bohas C, Baudin E, Walter T
J Thorac Oncol 2019 Jun;14(6):993-1002. Epub 2019 Feb 13 doi: 10.1016/j.jtho.2019.02.002. PMID: 30771520

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.

Lung cancer preneoplasia.

Wistuba II, Gazdar AF
Annu Rev Pathol 2006;1:331-48. doi: 10.1146/annurev.pathol.1.110304.100103. PMID: 18039118

See all (102)

Prognosis

Carcinoid tumors outside the abdomen.

Koehler K, Iams WT
Cancer Med 2023 Apr;12(7):7893-7903. Epub 2022 Dec 22 doi: 10.1002/cam4.5564. PMID: 36560885 Free PMC Article

Characterization, Prognosis, and Treatment of Patients With Metastatic Lung Carcinoid Tumors.

Advanced typical and atypical carcinoid tumours of the lung: management recommendations.

Melosky B
Curr Oncol 2018 Jun;25(Suppl 1):S86-S93. Epub 2018 Jun 13 doi: 10.3747/co.25.3808. PMID: 29910651 Free PMC Article

Classification and Pathology of Lung Cancer.

Zheng M
Surg Oncol Clin N Am 2016 Jul;25(3):447-68. doi: 10.1016/j.soc.2016.02.003. PMID: 27261908

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.

See all (374)

Clinical prediction guides

Lung carcinoid tumours: histology and Ki-67, the eternal rivalry.

Lung Neuroendocrine Tumors: How Does Molecular Profiling Help?

Sun TY, Hendifar A, Padda SK
Curr Oncol Rep 2022 Jul;24(7):819-824. Epub 2022 Mar 19 doi: 10.1007/s11912-022-01253-9. PMID: 35305210

Small-Cell Carcinoma of the Lung: What We Learned about It?

Righi L, Volante M, Papotti M
Acta Cytol 2022;66(4):257-268. Epub 2021 Nov 16 doi: 10.1159/000519688. PMID: 34784591

Clinical implications of lung neuroendocrine neoplasm classification.

Metovic J, Barella M, Harari S, Pattini L, Albini A, Sonzogni A, Veronesi G, Papotti M, Pelosi G
Expert Rev Anticancer Ther 2021 Apr;21(4):377-387. Epub 2020 Dec 24 doi: 10.1080/14737140.2021.1862654. PMID: 33306420

Classification of lung neuroendocrine tumors: lights and shadows.

Volante M, Gatti G, Papotti M
Endocrine 2015 Nov;50(2):315-9. Epub 2015 Mar 21 doi: 10.1007/s12020-015-0578-x. PMID: 25795289

See all (231)

Recent systematic reviews

An Assessment of Circulating Chromogranin A as a Biomarker of Bronchopulmonary Neuroendocrine Neoplasia: A Systematic Review and Meta-Analysis.

Malczewska A, Kidd M, Matar S, Kos-Kudła B, Bodei L, Oberg K, Modlin IM
Neuroendocrinology 2020;110(3-4):198-216. Epub 2019 Jul 5 doi: 10.1159/000500525. PMID: 31266019

The utility of 18F-FDG and 68Ga-DOTA-Peptide PET/CT in the evaluation of primary pulmonary carcinoid: A systematic review and meta-analysis.

Jiang Y, Hou G, Cheng W
Medicine (Baltimore) 2019 Mar;98(10):e14769. doi: 10.1097/MD.0000000000014769. PMID: 30855482 Free PMC Article

The use of Ki-67 labeling index to grade pulmonary well-differentiated neuroendocrine neoplasms: current best evidence.

Marchevsky AM, Hendifar A, Walts AE
Mod Pathol 2018 Oct;31(10):1523-1531. Epub 2018 May 25 doi: 10.1038/s41379-018-0076-9. PMID: 29802361

Neuroendrocrine tumors of the uterine cervix: A therapeutic challenge for gynecologic oncologists.

Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354

Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for best practice for typical and atypical pulmonary carcinoids.

See all (5)