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Lung Squamous Cell Carcinoma, Papillary Variant

MedGen UID:
318200
•Concept ID:
C1710175
•
Neoplastic Process

Definition

A morphologic variant of squamous cell lung carcinoma characterized by the presence of papillary structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Squamous Cell Carcinoma, Papillary Variant

Recent clinical studies

Etiology

Ancestry-specific predisposing germline variants in cancer.
Oak N, Cherniack AD, Mashl RJ; TCGA Analysis Network, Hirsch FR, Ding L, Beroukhim R, Gümüş ZH, Plon SE, Huang KL
Genome Med 2020 May 29;12(1):51. doi: 10.1186/s13073-020-00744-3. PMID: 32471518Free PMC Article
Case of rapidly progressing condylomatous squamous cell carcinoma of the uterine cervix associated with low-risk human papillomavirus type 6.
Masuda M, Abiko K, Minamiguchi S, Murakami R, Baba T, Konishi I
J Obstet Gynaecol Res 2018 Mar;44(3):583-587. Epub 2017 Dec 14 doi: 10.1111/jog.13553. PMID: 29239064
Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.
Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD
Am J Surg Pathol 2009 Dec;33(12):1752-64. doi: 10.1097/PAS.0b013e3181b8cf03. PMID: 19773638Free PMC Article
Pulmonary adenocarcinoma: the expanding spectrum of histologic variants.
Moran CA
Arch Pathol Lab Med 2006 Jul;130(7):958-62. doi: 10.5858/2006-130-958-PATESO. PMID: 16831050

Diagnosis

A case report of papillary thyroid carcinoma dedifferentiated to squamous cell carcinoma presenting as a lung metastasis: A potential diagnostic pitfall.
Gadde R, Tafe LJ, Tsapakos MJ, Liu X
Diagn Cytopathol 2020 Jun;48(6):581-585. Epub 2020 Apr 9 doi: 10.1002/dc.24422. PMID: 32271487
Case of rapidly progressing condylomatous squamous cell carcinoma of the uterine cervix associated with low-risk human papillomavirus type 6.
Masuda M, Abiko K, Minamiguchi S, Murakami R, Baba T, Konishi I
J Obstet Gynaecol Res 2018 Mar;44(3):583-587. Epub 2017 Dec 14 doi: 10.1111/jog.13553. PMID: 29239064
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Papillary endobronchial squamous cell carcinoma.
Cooper L, Hagenschneider JK, Banky S, Rosado-de-Christenson ML, Suster S
Ann Diagn Pathol 2005 Oct;9(5):284-8. doi: 10.1016/j.anndiagpath.2005.05.007. PMID: 16198957
Xeroderma pigmentosum variant associated with multiple skin cancers and a lung cancer.
Mamada A, Miura K, Tsunoda K, Hirose I, Furuya M, Kondo S
Dermatology 1992;184(3):177-81. doi: 10.1159/000247536. PMID: 1392108

Prognosis

Ancestry-specific predisposing germline variants in cancer.
Oak N, Cherniack AD, Mashl RJ; TCGA Analysis Network, Hirsch FR, Ding L, Beroukhim R, Gümüş ZH, Plon SE, Huang KL
Genome Med 2020 May 29;12(1):51. doi: 10.1186/s13073-020-00744-3. PMID: 32471518Free PMC Article
Pulmonary adenocarcinoma with high-grade fetal adenocarcinoma component has a poor prognosis, comparable to that of micropapillary adenocarcinoma.
Suzuki M, Nakatani Y, Ito H, Narimatsu H, Yamada K, Yoshioka E, Washimi K, Okubo Y, Kawachi K, Miyagi Y, Yokose T
Mod Pathol 2018 Sep;31(9):1404-1417. Epub 2018 May 21 doi: 10.1038/s41379-018-0057-z. PMID: 29785018
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.
Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD
Am J Surg Pathol 2009 Dec;33(12):1752-64. doi: 10.1097/PAS.0b013e3181b8cf03. PMID: 19773638Free PMC Article

Clinical prediction guides

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.
Girard N, Deshpande C, Lau C, Finley D, Rusch V, Pao W, Travis WD
Am J Surg Pathol 2009 Dec;33(12):1752-64. doi: 10.1097/PAS.0b013e3181b8cf03. PMID: 19773638Free PMC Article

Recent systematic reviews

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

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