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Conjunctival tumor

MedGen UID:
3208
•Concept ID:
C0009761
•
Neoplastic Process
Synonyms: Conjunctival Neoplasm; Conjunctival Neoplasms; Neoplasm, Conjunctival; Neoplasms, Conjunctival
SNOMED CT: Neoplasm of conjunctiva (126996004); Tumor of conjunctiva (126996004)
 
Monarch Initiative: MONDO:0020204

Definition

A benign or malignant neoplasm that affects the conjunctiva. Representative examples include papilloma, squamous cell carcinoma, and melanoma. [from NCI]

Professional guidelines

PubMed

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Interventional Radiotherapy (Brachytherapy) in Eyelid and Ocular Surface Tumors: A Review for Treatment of Naïve and Recurrent Malignancies.
Pagliara MM, Kakkassery V, Fionda B, Lepore D, Kovács G, Tagliaferri L, Blasi MA
Neurosignals 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505. PMID: 35333486
Topical mitomycin C for the treatment of conjunctival tumor.
Ozcan AA, Sizmaz S, Yagmur M
Ophthalmologica 2007;221(1):14-7. doi: 10.1159/000096516. PMID: 17183195

Recent clinical studies

Etiology

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Epidemiology and clinical characteristics of congenital choristomas in the ocular adnexa of pediatric patients.
Turanzas NJ, von Holstein SL, Wiencke AK, Toft PB, Heegaard S, Kessel L
Graefes Arch Clin Exp Ophthalmol 2022 Sep;260(9):3069-3074. Epub 2022 Apr 21 doi: 10.1007/s00417-022-05652-3. PMID: 35445875
Interventional Radiotherapy (Brachytherapy) in Eyelid and Ocular Surface Tumors: A Review for Treatment of Naïve and Recurrent Malignancies.
Pagliara MM, Kakkassery V, Fionda B, Lepore D, Kovács G, Tagliaferri L, Blasi MA
Neurosignals 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505. PMID: 35333486
Clinical Features Differentiating Benign From Malignant Conjunctival Tumors in Children.
Shields CL, Sioufi K, Alset AE, Boal NS, Casey MG, Knapp AN, Sugarman JA, Schoen MA, Gordon PS, Say EA, Shields JA
JAMA Ophthalmol 2017 Mar 1;135(3):215-224. doi: 10.1001/jamaophthalmol.2016.5544. PMID: 28125759
Amniotic membrane transplantation for conjunctival tumor.
Chen Z, Yan J, Yang H, Wu Z, Pang Y, Ai S, Mao Y
Yan Ke Xue Bao 2003 Sep;19(3):165-7, 145. PMID: 14574973

Diagnosis

Interventional Radiotherapy (Brachytherapy) in Eyelid and Ocular Surface Tumors: A Review for Treatment of Naïve and Recurrent Malignancies.
Pagliara MM, Kakkassery V, Fionda B, Lepore D, Kovács G, Tagliaferri L, Blasi MA
Neurosignals 2022 Mar 25;30(S1):1-10. doi: 10.33594/000000505. PMID: 35333486
Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119
Ocular Oncology-Primary and Metastatic Malignancies.
Williams BK Jr, Di Nicola M
Med Clin North Am 2021 May;105(3):531-550. Epub 2021 Apr 2 doi: 10.1016/j.mcna.2021.02.005. PMID: 33926645
Swept-Source and Spectral-Domain OCT Imaging of Conjunctival Tumors.
Nahon-Estève S, Martel A, Maschi C, Baillif S, Lassalle S, Caujolle JP
Ophthalmology 2021 Jun;128(6):947-950. Epub 2020 Sep 29 doi: 10.1016/j.ophtha.2020.09.036. PMID: 33007339
Salmon Patch Conjunctival Tumor.
Yong GY, Ab-Ghani S, Hanafi H
J Pediatr 2020 Oct;225:277-278. Epub 2020 Jun 5 doi: 10.1016/j.jpeds.2020.05.062. PMID: 32511962

Therapy

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Clinical Management of Squamous Cell Carcinoma of the Conjunctiva.
Röck T, Bartz-Schmidt KU, Bramkamp M, Milla J, Bösmüller HC, Röck D
Am J Case Rep 2020 Feb 1;21:e919751. doi: 10.12659/AJCR.919751. PMID: 32005796Free PMC Article
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review.
Shimono J, Kaino S, Okada K, Oshimi K, Ishida Y, Takahashi T, Miyagishima T, Teshima T
J Clin Exp Hematop 2017;57(3):143-146. doi: 10.3960/jslrt.17027. PMID: 29279551Free PMC Article
Plaque radiotherapy in the management of scleral-invasive conjunctival squamous cell carcinoma: an analysis of 15 eyes.
Arepalli S, Kaliki S, Shields CL, Emrich J, Komarnicky L, Shields JA
JAMA Ophthalmol 2014 Jun;132(6):691-6. doi: 10.1001/jamaophthalmol.2014.86. PMID: 24557333
Topical mitomycin C for extensive, recurrent conjunctival-corneal squamous cell carcinoma.
Shields CL, Naseripour M, Shields JA
Am J Ophthalmol 2002 May;133(5):601-6. doi: 10.1016/s0002-9394(02)01400-9. PMID: 11992855

Prognosis

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Epidemiology and clinical characteristics of congenital choristomas in the ocular adnexa of pediatric patients.
Turanzas NJ, von Holstein SL, Wiencke AK, Toft PB, Heegaard S, Kessel L
Graefes Arch Clin Exp Ophthalmol 2022 Sep;260(9):3069-3074. Epub 2022 Apr 21 doi: 10.1007/s00417-022-05652-3. PMID: 35445875
Ocular Oncology-Primary and Metastatic Malignancies.
Williams BK Jr, Di Nicola M
Med Clin North Am 2021 May;105(3):531-550. Epub 2021 Apr 2 doi: 10.1016/j.mcna.2021.02.005. PMID: 33926645
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review.
Shimono J, Kaino S, Okada K, Oshimi K, Ishida Y, Takahashi T, Miyagishima T, Teshima T
J Clin Exp Hematop 2017;57(3):143-146. doi: 10.3960/jslrt.17027. PMID: 29279551Free PMC Article
Amniotic membrane transplantation for conjunctival tumor.
Chen Z, Yan J, Yang H, Wu Z, Pang Y, Ai S, Mao Y
Yan Ke Xue Bao 2003 Sep;19(3):165-7, 145. PMID: 14574973

Clinical prediction guides

Long term study of topical interferon α-2b eye drops as primary treatment of ocular surface squamous neoplasia.
Sripawadkul W, Reyes-Capo D, Zein M, Wylegala A, Albayyat G, Galor A, Karp CL
Ocul Surf 2023 Apr;28:108-114. Epub 2022 Dec 30 doi: 10.1016/j.jtos.2022.12.009. PMID: 36592780Free PMC Article
Use of High-Resolution Optical Coherence Tomography in the Surgical Management of Ocular Surface Squamous Neoplasia: A Pilot Study.
Karp CL, Mercado C, Venkateswaran N, Ruggeri M, Galor A, Garcia A, Sivaraman KR, Fernandez MP, Bermudez A, Dubovy SR
Am J Ophthalmol 2019 Oct;206:17-31. Epub 2019 Jun 1 doi: 10.1016/j.ajo.2019.05.017. PMID: 31163136Free PMC Article
Unilateral conjunctival infiltration of Adult T-cell leukemia/lymphoma. Case report and literature review.
Shimono J, Kaino S, Okada K, Oshimi K, Ishida Y, Takahashi T, Miyagishima T, Teshima T
J Clin Exp Hematop 2017;57(3):143-146. doi: 10.3960/jslrt.17027. PMID: 29279551Free PMC Article
Fibrous histiocytoma of the conjunctiva.
Kim HJ, Shields CL, Eagle RC Jr, Shields JA
Am J Ophthalmol 2006 Dec;142(6):1036-43. Epub 2006 Sep 1 doi: 10.1016/j.ajo.2006.07.025. PMID: 17157587
Amniotic membrane transplantation for conjunctival tumor.
Chen Z, Yan J, Yang H, Wu Z, Pang Y, Ai S, Mao Y
Yan Ke Xue Bao 2003 Sep;19(3):165-7, 145. PMID: 14574973

Recent systematic reviews

Conjunctival myxoma: A systematic review of a rare tumor.
Alvarado-Villacorta R, Torres Zavala NM, Marroquín Loayza L, Rodríguez-Reyes AA
Surv Ophthalmol 2022 May-Jun;67(3):729-740. Epub 2021 Aug 27 doi: 10.1016/j.survophthal.2021.08.007. PMID: 34461119

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