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Myopia 6(MYP6)

MedGen UID:
324696
•Concept ID:
C1837148
•
Disease or Syndrome
Synonyms: Myopia, susceptibility to; MYP6
 
Gene (location): SCO2 (22q13.33)
 
Monarch Initiative: MONDO:0012154
OMIM®: 608908

Definition

Myopia, or nearsightedness, is a refractive error of the eye. Light rays from a distant object are focused in front of the retina and those from a near object are focused in the retina; therefore distant objects are blurry and near objects are clear (summary by Kaiser et al., 2004). For a discussion of genetic heterogeneity of susceptibility to myopia, see 160700. [from OMIM]

Clinical features

From HPO
High myopia
MedGen UID:
78759
•Concept ID:
C0271183
•
Disease or Syndrome
A severe form of myopia with greater than -6.00 diopters.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Primary retinopexy in preventing retinal detachment in a tertiary eye hospital: a study of 1157 eyes.
Moussa G, Samia-Aly E, Ch'ng SW, Lett KS, Mitra A, Tyagi AK, Sharma A, Andreatta W
Eye (Lond) 2022 May;36(5):1080-1085. Epub 2021 May 25 doi: 10.1038/s41433-021-01581-3. PMID: 34035492Free PMC Article
Choice of Primary Rhegmatogenous Retinal Detachment Repair Method in US Commercially Insured and Medicare Advantage Patients, 2003-2016.
Reeves MG, Pershing S, Afshar AR
Am J Ophthalmol 2018 Dec;196:82-90. Epub 2018 Aug 23 doi: 10.1016/j.ajo.2018.08.024. PMID: 30144442
Visual quality of Q-value-guided LASIK in the treatment of high myopia.
Zheng H, Song L
Eye Sci 2011 Dec;26(4):208-10, 216. doi: 10.3969/j.issn.1000-4432.2011.04.005. PMID: 22187304

Recent clinical studies

Etiology

IMI-Management and Investigation of High Myopia in Infants and Young Children.
Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin ZB, Klaver CCW, Moore AT, Nischal KK, Ohno-Matsui K, Paysse EA, Repka MX, Smirnova IY, Snead M, Verhoeven VJM, Verkicharla PK
Invest Ophthalmol Vis Sci 2023 May 1;64(6):3. doi: 10.1167/iovs.64.6.3. PMID: 37126360Free PMC Article
Increasing prevalence of myopia and the impact of education in primary-school students in Xi'an, north-western of China.
Ye L, Yang YQ, Zhang GY, Wang WJ, Ren MX, Ge P, Zhang J, Zhang N, Liu XZ, Zhang ML, Tong YJ, Lu LC, Lv MQ, Zhou DX, Pei C
Front Public Health 2022;10:1070984. Epub 2022 Dec 19 doi: 10.3389/fpubh.2022.1070984. PMID: 36600934Free PMC Article
Changes in retinal vascular bifurcation in eyes with myopia.
Sun C, Chen T, Cong J, Wu X, Wang J, Yuan Y
BMC Ophthalmol 2022 Oct 21;22(1):408. doi: 10.1186/s12886-022-02629-y. PMID: 36271390Free PMC Article
Monochromatic higher order aberrations in highly myopic eyes with Staphyloma.
Delgado-Tirado S, López-Miguel A, Báez-Peralta Y, González-Buendía L, Fernández I, Alió JL, Maldonado MJ, Coco-Martín RM
BMC Ophthalmol 2021 May 18;21(1):223. doi: 10.1186/s12886-021-01965-9. PMID: 34006229Free PMC Article
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441

Diagnosis

Prevalence and associated factors of myopia in children and adolescents in Russia: the Ural Children Eye Study.
Bikbov MM, Kazakbaeva GM, Fakhretdinova AA, Tuliakova AM, Iakupova EM, Panda-Jonas S, Gilemzianova LI, Garipova LA, Khakimov DA, Islamova LI, Jonas JB
Br J Ophthalmol 2024 Mar 20;108(4):593-598. doi: 10.1136/bjo-2022-322945. PMID: 37019624
IMI-Management and Investigation of High Myopia in Infants and Young Children.
Flitcroft I, Ainsworth J, Chia A, Cotter S, Harb E, Jin ZB, Klaver CCW, Moore AT, Nischal KK, Ohno-Matsui K, Paysse EA, Repka MX, Smirnova IY, Snead M, Verhoeven VJM, Verkicharla PK
Invest Ophthalmol Vis Sci 2023 May 1;64(6):3. doi: 10.1167/iovs.64.6.3. PMID: 37126360Free PMC Article
Predictors of Pseudophakic Retinal Tears at a Tertiary Care Academic Medical Center.
Fonteh CN, Patnaik JL, Grove NC, Lynch AM, Christopher KL
Ophthalmol Retina 2022 Jun;6(6):450-456. Epub 2022 Jan 31 doi: 10.1016/j.oret.2022.01.010. PMID: 35093584
Contrast sensitivity of amblyopic eyes in children with myopic anisometropia.
Pang Y, Allen M, Robinson J, Frantz KA
Clin Exp Optom 2019 Jan;102(1):57-62. Epub 2018 Jul 28 doi: 10.1111/cxo.12817. PMID: 30054940
Optical Coherence Tomography Angiography of Choroidal Neovascularization Secondary to Pathologic Myopia.
Querques G, Corvi F, Querques L, Souied EH, Bandello F
Dev Ophthalmol 2016;56:101-6. Epub 2016 Mar 15 doi: 10.1159/000442800. PMID: 27023343

Therapy

Clinical Evaluation of MyoCare in Europe (CEME): study protocol for a prospective, multicenter, randomized, double-blinded, and controlled clinical trial.
Alvarez-Peregrina C, Sanchez-Tena MA, Martinez-Perez C, Villa-Collar C; Clinical Evaluation of MyoCare in Europe –the CEME Study Group, Ohlendorf A
Trials 2023 Oct 17;24(1):674. doi: 10.1186/s13063-023-07696-0. PMID: 37848908Free PMC Article
Evolution of the Prevalence of Myopia among Taiwanese Schoolchildren: A Review of Survey Data from 1983 through 2017.
Tsai TH, Liu YL, Ma IH, Su CC, Lin CW, Lin LL, Hsiao CK, Wang IJ
Ophthalmology 2021 Feb;128(2):290-301. Epub 2020 Jul 15 doi: 10.1016/j.ophtha.2020.07.017. PMID: 32679159
Z-LASIK and Trans-PRK for correction of high-grade myopia: safety, efficacy, predictability and clinical outcomes.
Gershoni A, Mimouni M, Livny E, Bahar I
Int Ophthalmol 2019 Apr;39(4):753-763. Epub 2018 Mar 12 doi: 10.1007/s10792-018-0868-4. PMID: 29532217
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Prevalence and associated factors of myopia in high-school students in Beijing.
Wu LJ, You QS, Duan JL, Luo YX, Liu LJ, Li X, Gao Q, Zhu HP, He Y, Xu L, Jonas JB, Wang W, Guo XH
PLoS One 2015;10(3):e0120764. Epub 2015 Mar 24 doi: 10.1371/journal.pone.0120764. PMID: 25803875Free PMC Article

Prognosis

Predictors of Pseudophakic Retinal Tears at a Tertiary Care Academic Medical Center.
Fonteh CN, Patnaik JL, Grove NC, Lynch AM, Christopher KL
Ophthalmol Retina 2022 Jun;6(6):450-456. Epub 2022 Jan 31 doi: 10.1016/j.oret.2022.01.010. PMID: 35093584
Progression and Longitudinal Biometric Changes in Highly Myopic Eyes.
Lee JTL, Guo X, Li Z, Jong M, Sankaridurg P, He M
Invest Ophthalmol Vis Sci 2020 Apr 9;61(4):34. doi: 10.1167/iovs.61.4.34. PMID: 32334434Free PMC Article
Association Between Hay Fever and High Myopia in United States Adolescents and Adults.
Shafer BM, Qiu M, Rapuano CJ, Shields CL
Eye Contact Lens 2017 May;43(3):186-191. doi: 10.1097/ICL.0000000000000251. PMID: 26974535
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Myopia and incident cataract and cataract surgery: the blue mountains eye study.
Younan C, Mitchell P, Cumming RG, Rochtchina E, Wang JJ
Invest Ophthalmol Vis Sci 2002 Dec;43(12):3625-32. PMID: 12454028

Clinical prediction guides

Changes in retinal vascular bifurcation in eyes with myopia.
Sun C, Chen T, Cong J, Wu X, Wang J, Yuan Y
BMC Ophthalmol 2022 Oct 21;22(1):408. doi: 10.1186/s12886-022-02629-y. PMID: 36271390Free PMC Article
Monochromatic higher order aberrations in highly myopic eyes with Staphyloma.
Delgado-Tirado S, López-Miguel A, Báez-Peralta Y, González-Buendía L, Fernández I, Alió JL, Maldonado MJ, Coco-Martín RM
BMC Ophthalmol 2021 May 18;21(1):223. doi: 10.1186/s12886-021-01965-9. PMID: 34006229Free PMC Article
Epidemiology of Myopia.
Wu PC, Huang HM, Yu HJ, Fang PC, Chen CT
Asia Pac J Ophthalmol (Phila) 2016 Nov/Dec;5(6):386-393. doi: 10.1097/APO.0000000000000236. PMID: 27898441
Study of the relationship between myopia and personality.
Rodríguez Uña I, Pérez Bartolomé F, Urriés Ortiz M, Arriola Villalobos P, Bermúdez Vallecilla M, Fernández-Vega Cueto L, Martín Villaescusa C, Marticorena Álvarez P
Arch Soc Esp Oftalmol 2015 Aug;90(8):365-72. Epub 2015 Mar 24 doi: 10.1016/j.oftal.2015.01.005. PMID: 25817967
Regulation of scleral metabolism in myopia and the role of transforming growth factor-beta.
McBrien NA
Exp Eye Res 2013 Sep;114:128-40. Epub 2013 Feb 8 doi: 10.1016/j.exer.2013.01.014. PMID: 23399866

Recent systematic reviews

Duration of topical steroid application after photorefractive keratectomy with mitomycin C.
Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpour E, Aghamirsalim M, Seyedian MA, Hashemi H
J Cataract Refract Surg 2020 Apr;46(4):622-632. doi: 10.1097/j.jcrs.0000000000000060. PMID: 32271298
Do findings on routine examination identify patients at risk for primary open-angle glaucoma? The rational clinical examination systematic review.
Hollands H, Johnson D, Hollands S, Simel DL, Jinapriya D, Sharma S
JAMA 2013 May 15;309(19):2035-42. doi: 10.1001/jama.2013.5099. PMID: 23677315

Supplemental Content

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      Clinical tests in GTR
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      Related records in OMIM
    • OMIM(Genes)
      OMIM records containing genes associated with phenotypes registered in MedGen
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