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Immune suppression(IS)

MedGen UID:
326692
•Concept ID:
C1840264
•
Disease or Syndrome
Synonyms: IS; STREPTOCOCCAL CELL WALL ANTIGEN, SUPPRESSION OF IMMUNE RESPONSE TO
 
OMIM®: 146850

Clinical features

From HPO
Abnormality of the immune system
MedGen UID:
867388
•Concept ID:
C4021753
•
Pathologic Function
An abnormality of the immune system.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Diagnosis and Management of Opsoclonus-Myoclonus-Ataxia Syndrome in Children: An International Perspective.
Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
Neurol Neuroimmunol Neuroinflamm 2022 May;9(3) Epub 2022 Mar 8 doi: 10.1212/NXI.0000000000001153. PMID: 35260471Free PMC Article
Management of Crohn Disease: A Review.
Cushing K, Higgins PDR
JAMA 2021 Jan 5;325(1):69-80. doi: 10.1001/jama.2020.18936. PMID: 33399844Free PMC Article
Mechanisms and treatment of organ failure in sepsis.
Lelubre C, Vincent JL
Nat Rev Nephrol 2018 Jul;14(7):417-427. doi: 10.1038/s41581-018-0005-7. PMID: 29691495

Recent clinical studies

Etiology

Oral antiviral drugs for treatment of cytomegalovirus in transplant recipients.
Razonable RR
Clin Microbiol Infect 2023 Sep;29(9):1144-1149. Epub 2023 Mar 23 doi: 10.1016/j.cmi.2023.03.020. PMID: 36963566
Immunotherapy for hepatocellular carcinoma: Recent advances and future targets.
Yu SJ
Pharmacol Ther 2023 Apr;244:108387. Epub 2023 Mar 21 doi: 10.1016/j.pharmthera.2023.108387. PMID: 36948423
Immunopathophysiology of human sepsis.
Wiersinga WJ, van der Poll T
EBioMedicine 2022 Dec;86:104363. Epub 2022 Dec 2 doi: 10.1016/j.ebiom.2022.104363. PMID: 36470832Free PMC Article
Immunosuppressive Agents and Infectious Risk in Transplantation: Managing the "Net State of Immunosuppression".
Roberts MB, Fishman JA
Clin Infect Dis 2021 Oct 5;73(7):e1302-e1317. doi: 10.1093/cid/ciaa1189. PMID: 32803228Free PMC Article
Infection in Organ Transplantation.
Fishman JA
Am J Transplant 2017 Apr;17(4):856-879. Epub 2017 Mar 10 doi: 10.1111/ajt.14208. PMID: 28117944

Diagnosis

Metabolic programming and immune suppression in the tumor microenvironment.
Arner EN, Rathmell JC
Cancer Cell 2023 Mar 13;41(3):421-433. Epub 2023 Feb 16 doi: 10.1016/j.ccell.2023.01.009. PMID: 36801000Free PMC Article
Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials.
Zipser CM, Cragg JJ, Guest JD, Fehlings MG, Jutzeler CR, Anderson AJ, Curt A
Lancet Neurol 2022 Jul;21(7):659-670. Epub 2022 May 12 doi: 10.1016/S1474-4422(21)00464-6. PMID: 35569486
Strongyloides stercoralis.
Czeresnia JM, Weiss LM
Lung 2022 Apr;200(2):141-148. Epub 2022 Apr 9 doi: 10.1007/s00408-022-00528-z. PMID: 35396957Free PMC Article
Systemic sclerosis.
Denton CP, Khanna D
Lancet 2017 Oct 7;390(10103):1685-1699. Epub 2017 Apr 13 doi: 10.1016/S0140-6736(17)30933-9. PMID: 28413064
Infection in Organ Transplantation.
Fishman JA
Am J Transplant 2017 Apr;17(4):856-879. Epub 2017 Mar 10 doi: 10.1111/ajt.14208. PMID: 28117944

Therapy

Mild Crohn's Disease: Definition and Management.
Claytor J, Kumar P, Ananthakrishnan AN, Colombel JF, Agrawal M, Ungaro RC
Curr Gastroenterol Rep 2023 Mar;25(3):45-51. Epub 2023 Feb 8 doi: 10.1007/s11894-023-00863-y. PMID: 36753033
Immunopathophysiology of human sepsis.
Wiersinga WJ, van der Poll T
EBioMedicine 2022 Dec;86:104363. Epub 2022 Dec 2 doi: 10.1016/j.ebiom.2022.104363. PMID: 36470832Free PMC Article
Future Projections in Thyroid Eye Disease.
Barbesino G, Salvi M, Freitag SK
J Clin Endocrinol Metab 2022 Aug 8;107(Suppl_1):S47-S56. doi: 10.1210/clinem/dgac252. PMID: 36346684Free PMC Article
Recent advances in the mechanisms and treatment of immune thrombocytopenia.
Provan D, Semple JW
EBioMedicine 2022 Feb;76:103820. Epub 2022 Jan 21 doi: 10.1016/j.ebiom.2022.103820. PMID: 35074629Free PMC Article
Challenges and Opportunities for Pancreatic Cancer Immunotherapy.
Bear AS, Vonderheide RH, O'Hara MH
Cancer Cell 2020 Dec 14;38(6):788-802. Epub 2020 Sep 17 doi: 10.1016/j.ccell.2020.08.004. PMID: 32946773Free PMC Article

Prognosis

CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G
N Engl J Med 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. PMID: 38381673
Sepsis-Induced Immunosuppression.
Torres LK, Pickkers P, van der Poll T
Annu Rev Physiol 2022 Feb 10;84:157-181. Epub 2021 Oct 27 doi: 10.1146/annurev-physiol-061121-040214. PMID: 34705481
Macrophage Biology and Mechanisms of Immune Suppression in Breast Cancer.
Mehta AK, Kadel S, Townsend MG, Oliwa M, Guerriero JL
Front Immunol 2021;12:643771. Epub 2021 Apr 23 doi: 10.3389/fimmu.2021.643771. PMID: 33968034Free PMC Article
The TIM3/Gal9 signaling pathway: An emerging target for cancer immunotherapy.
Kandel S, Adhikary P, Li G, Cheng K
Cancer Lett 2021 Jul 10;510:67-78. Epub 2021 Apr 22 doi: 10.1016/j.canlet.2021.04.011. PMID: 33895262Free PMC Article
Epidemiology of skin cancer.
Leiter U, Eigentler T, Garbe C
Adv Exp Med Biol 2014;810:120-40. doi: 10.1007/978-1-4939-0437-2_7. PMID: 25207363

Clinical prediction guides

CD19 CAR T-Cell Therapy in Autoimmune Disease - A Case Series with Follow-up.
Müller F, Taubmann J, Bucci L, Wilhelm A, Bergmann C, Völkl S, Aigner M, Rothe T, Minopoulou I, Tur C, Knitza J, Kharboutli S, Kretschmann S, Vasova I, Spoerl S, Reimann H, Munoz L, Gerlach RG, Schäfer S, Grieshaber-Bouyer R, Korganow AS, Farge-Bancel D, Mougiakakos D, Bozec A, Winkler T, Krönke G, Mackensen A, Schett G
N Engl J Med 2024 Feb 22;390(8):687-700. doi: 10.1056/NEJMoa2308917. PMID: 38381673
Future Projections in Thyroid Eye Disease.
Barbesino G, Salvi M, Freitag SK
J Clin Endocrinol Metab 2022 Aug 8;107(Suppl_1):S47-S56. doi: 10.1210/clinem/dgac252. PMID: 36346684Free PMC Article
Sepsis-Induced Immunosuppression.
Torres LK, Pickkers P, van der Poll T
Annu Rev Physiol 2022 Feb 10;84:157-181. Epub 2021 Oct 27 doi: 10.1146/annurev-physiol-061121-040214. PMID: 34705481
The TIM3/Gal9 signaling pathway: An emerging target for cancer immunotherapy.
Kandel S, Adhikary P, Li G, Cheng K
Cancer Lett 2021 Jul 10;510:67-78. Epub 2021 Apr 22 doi: 10.1016/j.canlet.2021.04.011. PMID: 33895262Free PMC Article
Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression.
Fousek K, Horn LA, Palena C
Pharmacol Ther 2021 Mar;219:107692. Epub 2020 Sep 24 doi: 10.1016/j.pharmthera.2020.107692. PMID: 32980444Free PMC Article

Recent systematic reviews

Characteristics of Progressive Multifocal Leukoencephalopathy Associated With Sarcoidosis Without Therapeutic Immune Suppression.
McEntire CRS, Fletcher A, Toledano M, Epstein S, White E, Tan CS, Mao-Draayer Y, Banks SA, Aksamit AJ, Gelfand JM, Thakur KT, Anand P, Cortese I, Bhattacharyya S
JAMA Neurol 2023 Jun 1;80(6):624-633. doi: 10.1001/jamaneurol.2023.0841. PMID: 37093609Free PMC Article
The role of immunological testing and intervention in reproductive medicine: A fertile collaboration?
Ali SB, Jeelall Y, Pennell CE, Hart R, McLean-Tooke A, Lucas M
Am J Reprod Immunol 2018 Mar;79(3) Epub 2017 Nov 20 doi: 10.1111/aji.12784. PMID: 29154465
Statin-Associated Autoimmune Myopathy: A Systematic Review of 100 Cases.
Nazir S, Lohani S, Tachamo N, Poudel D, Donato A
J Clin Rheumatol 2017 Apr;23(3):149-154. doi: 10.1097/RHU.0000000000000497. PMID: 28277343
Cancer Recurrence Following Immune-Suppressive Therapies in Patients With Immune-Mediated Diseases: A Systematic Review and Meta-analysis.
Shelton E, Laharie D, Scott FI, Mamtani R, Lewis JD, Colombel JF, Ananthakrishnan AN
Gastroenterology 2016 Jul;151(1):97-109.e4. Epub 2016 Apr 1 doi: 10.1053/j.gastro.2016.03.037. PMID: 27039969Free PMC Article
Smoking habit, immune suppression, oral contraceptive use, and hormone replacement therapy use and cervical carcinogenesis: a review of the literature.
Gadducci A, Barsotti C, Cosio S, Domenici L, Riccardo Genazzani A
Gynecol Endocrinol 2011 Aug;27(8):597-604. Epub 2011 Mar 25 doi: 10.3109/09513590.2011.558953. PMID: 21438669

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