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Major affective disorder 2(MAFD2)

MedGen UID:
326975
•Concept ID:
C1839839
•
Mental or Behavioral Dysfunction
Synonyms: MAFD2; MANIC-DEPRESSIVE ILLNESS; MANIC-DEPRESSIVE PSYCHOSIS, X-LINKED
 
Monarch Initiative: MONDO:0010648
OMIM®: 309200

Clinical features

From HPO
Bipolar affective disorder
MedGen UID:
2649
•Concept ID:
C0005586
•
Mental or Behavioral Dysfunction
Bipolar disorder is an illness of mood characterized by alternating episodes of elevated and depressed moods, which are interspersed with euthymic periods.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Curated

UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

Recent clinical studies

Etiology

Empirical validity of Leonhard's psychoses: A long-term follow-up study of first-episode psychosis patients.
Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995
Philipp Jolly and his 1913 "the heredity of psychosis": Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic-depressive illness and dementia praecox.
Kendler KS, Klee A
Am J Med Genet B Neuropsychiatr Genet 2021 Mar;186(2):90-100. Epub 2021 Jan 22 doi: 10.1002/ajmg.b.32831. PMID: 33484094

Diagnosis

Kraepelin's final views on manic-depressive Illness.
Kendler KS
J Affect Disord 2021 Mar 1;282:979-990. Epub 2021 Jan 6 doi: 10.1016/j.jad.2020.12.200. PMID: 33601743
Dreyfus and the shift of melancholia in Kraepelin's textbooks from an involutional to a manic-depressive illness.
Kendler KS, Engstrom EJ
J Affect Disord 2020 Jun 1;270:42-50. Epub 2020 Mar 29 doi: 10.1016/j.jad.2020.03.094. PMID: 32275219
The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900.
Kendler KS
Mol Psychiatry 2017 Nov;22(11):1539-1553. Epub 2017 Aug 8 doi: 10.1038/mp.2017.148. PMID: 28785109
Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness.
Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114Free PMC Article
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Therapy

Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness.
Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114Free PMC Article
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279
Prescribing patterns of antidepressants, antipsychotics and mood stabilizers in bipolar patients misdiagnosed with major depressive disorder in China.
Xiang YT, Hu C, Wang G, Zheng QW, Fang YR, Ungvari GS, Kilbourne AM, Lai KY, Si TM, Chen DF, Lu Z, Yang HC, Hu J, Chen ZY, Huang Y, Sun J, Wang XP, Li HC, Zhang JB, Chiu HF
Hum Psychopharmacol 2012 Nov;27(6):626-31. Epub 2012 Oct 2 doi: 10.1002/hup.2262. PMID: 23027671

Prognosis

Empirical validity of Leonhard's psychoses: A long-term follow-up study of first-episode psychosis patients.
Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995
Dreyfus and the shift of melancholia in Kraepelin's textbooks from an involutional to a manic-depressive illness.
Kendler KS, Engstrom EJ
J Affect Disord 2020 Jun 1;270:42-50. Epub 2020 Mar 29 doi: 10.1016/j.jad.2020.03.094. PMID: 32275219
The genealogy of major depression: symptoms and signs of melancholia from 1880 to 1900.
Kendler KS
Mol Psychiatry 2017 Nov;22(11):1539-1553. Epub 2017 Aug 8 doi: 10.1038/mp.2017.148. PMID: 28785109

Clinical prediction guides

Empirical validity of Leonhard's psychoses: A long-term follow-up study of first-episode psychosis patients.
Cuesta MJ, Sánchez-Torres AM, García de Jalón E, Moreno-Izco L, Gil-Berrozpe GJ, Zarzuela A, Papiol S, Fañanás L, Peralta V; SEGPEPs Group
Schizophr Res 2024 Jan;263:237-245. Epub 2023 Jan 20 doi: 10.1016/j.schres.2022.12.022. PMID: 36682995
Philipp Jolly and his 1913 "the heredity of psychosis": Homogeneity versus heterogeneity of familial transmission and an early look at Mendelian models for manic-depressive illness and dementia praecox.
Kendler KS, Klee A
Am J Med Genet B Neuropsychiatr Genet 2021 Mar;186(2):90-100. Epub 2021 Jan 22 doi: 10.1002/ajmg.b.32831. PMID: 33484094
Antidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness.
Demontis F, Serra F, Serra G
Curr Neuropharmacol 2017 Apr;15(3):417-423. doi: 10.2174/1570159X14666160715165648. PMID: 28503114Free PMC Article
Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Recent systematic reviews

Depressive mixed states: A reappraisal of Koukopoulos' criteria.
Faedda GL, Marangoni C, Reginaldi D
J Affect Disord 2015 May 1;176:18-23. Epub 2015 Feb 4 doi: 10.1016/j.jad.2015.01.053. PMID: 25687279

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE Clinical Guideline CG185, Bipolar disorder: assessment and management, 2023

    Consumer resources

    Reviews

    Related information

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    • OMIM
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    • PMC Articles
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