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Small Intestinal Undifferentiated Carcinoma

MedGen UID:
328037
•Concept ID:
C1710114
•
Neoplastic Process

Definition

A carcinoma that arises from the small intestine. It is composed of malignant epithelial cells which do not display evidence of glandular, squamous, or transitional cell differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSmall Intestinal Undifferentiated Carcinoma

Professional guidelines

PubMed

Clinical practice guidelines for duodenal cancer 2021.
Nakagawa K, Sho M, Fujishiro M, Kakushima N, Horimatsu T, Okada KI, Iguchi M, Uraoka T, Kato M, Yamamoto Y, Aoyama T, Akahori T, Eguchi H, Kanaji S, Kanetaka K, Kuroda S, Nagakawa Y, Nunobe S, Higuchi R, Fujii T, Yamashita H, Yamada S, Narita Y, Honma Y, Muro K, Ushiku T, Ejima Y, Yamaue H, Kodera Y
J Gastroenterol 2022 Dec;57(12):927-941. Epub 2022 Oct 19 doi: 10.1007/s00535-022-01919-y. PMID: 36260172Free PMC Article
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
Small Intestinal Bacterial Overgrowth and Non-Alcoholic Fatty Liver Disease: What Do We Know in 2023?
Gudan A, Kozłowska-Petriczko K, Wunsch E, Bodnarczuk T, Stachowska E
Nutrients 2023 Mar 8;15(6) doi: 10.3390/nu15061323. PMID: 36986052Free PMC Article
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Small bowel strictures.
Durmush D, Kaffes AJ
Curr Opin Gastroenterol 2019 May;35(3):235-242. doi: 10.1097/MOG.0000000000000531. PMID: 30865041
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842

Diagnosis

Updates in the diagnosis and management of small-bowel tumors.
Vlachou E, Koffas A, Toumpanakis C, Keuchel M
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101860. Epub 2023 Aug 12 doi: 10.1016/j.bpg.2023.101860. PMID: 37652650
The hairpin turn.
Bailey R, LeGout JD
Abdom Radiol (NY) 2020 Apr;45(4):1218-1219. doi: 10.1007/s00261-020-02422-9. PMID: 32008113
Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, Venook AP, Al-Hawary MM, Arain MA, Chen YJ, Ciombor KK, Cohen SA, Cooper HS, Deming DA, Garrido-Laguna I, Grem JL, Hoffe SE, Hubbard J, Hunt S, Kamel A, Kirilcuk N, Krishnamurthi S, Messersmith WA, Meyerhardt J, Miller ED, Mulcahy MF, Nurkin S, Overman MJ, Parikh A, Patel H, Pedersen KS, Saltz LB, Schneider C, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Johnson-Chilla A, Gregory KM, Gurski LA
J Natl Compr Canc Netw 2019 Sep 1;17(9):1109-1133. doi: 10.6004/jnccn.2019.0043. PMID: 31487687Free PMC Article
Small bowel strictures.
Durmush D, Kaffes AJ
Curr Opin Gastroenterol 2019 May;35(3):235-242. doi: 10.1097/MOG.0000000000000531. PMID: 30865041
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735

Therapy

Gastrointestinal toxicity of systemic oncology immunotherapy.
Bureš J, Kohoutová D, Zavoral M
Klin Onkol 2022 Fall;35(5):346-357. doi: 10.48095/ccko2022346. PMID: 36443091
Molecular pathways and targeted therapy in cholangiocarcinoma.
Dabney RS, Khalife M, Shahid K, Phan AT
Clin Adv Hematol Oncol 2019 Nov;17(11):630-637. PMID: 31851165
Small bowel strictures.
Durmush D, Kaffes AJ
Curr Opin Gastroenterol 2019 May;35(3):235-242. doi: 10.1097/MOG.0000000000000531. PMID: 30865041
Small Bowel Adenocarcinoma.
Aparicio T, Zaanan A, Mary F, Afchain P, Manfredi S, Evans TR
Gastroenterol Clin North Am 2016 Sep;45(3):447-57. doi: 10.1016/j.gtc.2016.04.004. PMID: 27546842
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Prognosis

The evolving management of small bowel adenocarcinoma.
de Bree E, Rovers KP, Stamatiou D, Souglakos J, Michelakis D, de Hingh IH
Acta Oncol 2018 Jun;57(6):712-722. Epub 2018 Jan 30 doi: 10.1080/0284186X.2018.1433321. PMID: 29381126
Advanced small bowel adenocarcinoma: Molecular characteristics and therapeutic perspectives.
Zaaimi Y, Aparicio T, Laurent-Puig P, Taieb J, Zaanan A
Clin Res Hepatol Gastroenterol 2016 Apr;40(2):154-60. Epub 2015 Nov 4 doi: 10.1016/j.clinre.2015.09.008. PMID: 26547136
Small bowel adenocarcinoma.
Zouhairi ME, Venner A, Charabaty A, Pishvaian MJ
Curr Treat Options Oncol 2008 Dec;9(4-6):388-99. Epub 2009 Apr 14 doi: 10.1007/s11864-009-0098-0. PMID: 19365735
Small-bowel tumors.
Minardi AJ Jr, Zibari GB, Aultman DF, McMillan RW, McDonald JC
J Am Coll Surg 1998 Jun;186(6):664-8. doi: 10.1016/s1072-7515(98)00092-1. PMID: 9632155
An overview of adenocarcinoma of the small intestine.
Neugut AI, Marvin MR, Rella VA, Chabot JA
Oncology (Williston Park) 1997 Apr;11(4):529-36; discussion 545, 549-50. PMID: 9130275

Clinical prediction guides

Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
Matsueda K, Kanzaki H, Takenaka R, Nakagawa M, Matsueda K, Iwamuro M, Kawano S, Kawahara Y, Toji T, Tanaka T, Yagi T, Fujiwara T, Okada H
PLoS One 2021;16(8):e0256797. Epub 2021 Aug 27 doi: 10.1371/journal.pone.0256797. PMID: 34449813Free PMC Article
Characterization and Clinical Outcomes of DNA Mismatch Repair-deficient Small Bowel Adenocarcinoma.
Latham A, Shia J, Patel Z, Reidy-Lagunes DL, Segal NH, Yaeger R, Ganesh K, Connell L, Kemeny NE, Kelsen DP, Hechtman JF, Nash GM, Paty PB, Zehir A, Tkachuk KA, Sheikh R, Markowitz AJ, Mandelker D, Offit K, Berger MF, Cercek A, Garcia-Aguilar J, Saltz LB, Weiser MR, Stadler ZK
Clin Cancer Res 2021 Mar 1;27(5):1429-1437. Epub 2020 Nov 16 doi: 10.1158/1078-0432.CCR-20-2892. PMID: 33199489Free PMC Article
SMALL INTESTINAL TUMORS.
Bozhkov V, Magjov R, Chernopolsky P, Arnaudov P, Plachkov I, Ivanov T
Khirurgiia (Sofiia) 2015;81(2):4-8. PMID: 26668984
A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Periampullary carcinomas.
Filiz G, Yerci O, Adim SB, Gurel S, Dolar E, Memik F
Hepatogastroenterology 2007 Jun;54(76):1247-9. PMID: 17629080

Recent systematic reviews

Evaluation of Systemic Treatments of Small Intestinal Adenocarcinomas: A Systematic Review and Meta-analysis.
de Back T, Nijskens I, Schafrat P, Chalabi M, Kazemier G, Vermeulen L, Sommeijer D
JAMA Netw Open 2023 Feb 1;6(2):e230631. doi: 10.1001/jamanetworkopen.2023.0631. PMID: 36826817Free PMC Article
A systematic review of the possible carcinogenic role of the aristolochic acid.
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I
Rom J Morphol Embryol 2017;58(1):41-44. PMID: 28523296
Natural history of diminutive and small colorectal polyps: a systematic literature review.
Vleugels JLA, Hazewinkel Y, Fockens P, Dekker E
Gastrointest Endosc 2017 Jun;85(6):1169-1176.e1. Epub 2016 Dec 23 doi: 10.1016/j.gie.2016.12.014. PMID: 28024986
Lifestyle factors and small intestine adenocarcinoma risk: A systematic review and meta-analysis.
Bennett CM, Coleman HG, Veal PG, Cantwell MM, Lau CC, Murray LJ
Cancer Epidemiol 2015 Jun;39(3):265-73. Epub 2015 Feb 27 doi: 10.1016/j.canep.2015.02.001. PMID: 25736860
Minimally invasive adrenalectomy in children.
Heloury Y, Muthucumaru M, Panabokke G, Cheng W, Kimber C, Leclair MD
J Pediatr Surg 2012 Feb;47(2):415-21. doi: 10.1016/j.jpedsurg.2011.08.003. PMID: 22325405

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