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Thyroid Gland Paraganglioma

MedGen UID:: 328114
•Concept ID:: C1710416
•: Neoplastic Process

Definition

A rare, circumscribed or encapsulated neuroendocrine tumor arising from the thyroid gland. Microscopically, it is characterized by the presence of tumor cells arranged in a nesting (Zellballen) growth pattern. The reported cases have followed a benign clinical course. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVThyroid Gland Paraganglioma

Phenotypic abnormality
- Neoplasm
  - Extra-Adrenal Paraganglioma
    - Paraganglioma of head and neck
      - Thyroid Gland Paraganglioma

Professional guidelines

PubMed

Genetic evaluation of patients and families with concern for hereditary endocrine tumor syndromes.

Anderson JL, Pilarski R, Kirschner L, Brock P
Fam Cancer 2022 Jan;21(1):93-100. Epub 2021 Jan 7 doi: 10.1007/s10689-020-00222-0. PMID: 33409929

Diagnosis for Pheochromocytoma and Paraganglioma: A Joint Position Statement of the Korean Pheochromocytoma and Paraganglioma Task Force.

Ku EJ, Kim KJ, Kim JH, Kim MK, Ahn CH, Lee KA, Lee SH, Lee YB, Park KH, Choi YM, Hong N, Hong AR, Kang SW, Park BK, Seong MW, Kim M, Jung KC, Jung CK, Cho YS, Paeng JC, Kim JH, Ryu OH, Rhee Y, Kim CH, Lee EJ
Endocrinol Metab (Seoul) 2021 Apr;36(2):322-338. Epub 2021 Apr 6 doi: 10.3803/EnM.2020.908. PMID: 33820394 Free PMC Article

Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.

Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662

See all (40)

Recent clinical studies

Etiology

Immunotherapy for endocrine tumours: a clinician's perspective.

Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757

Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations.

Chevalier B, Dupuis H, Jannin A, Lemaitre M, Do Cao C, Cardot-Bauters C, Espiard S, Vantyghem MC
Front Endocrinol (Lausanne) 2021;12:678869. Epub 2021 May 6 doi: 10.3389/fendo.2021.678869. PMID: 34025587 Free PMC Article

Genetics, diagnosis, and management of medullary thyroid carcinoma and pheochromocytoma/paraganglioma.

Moraitis AG, Martucci VL, Pacak K
Endocr Pract 2014 Feb;20(2):176-87. doi: 10.4158/EP13268.RA. PMID: 24449662

Familial pheochromocytoma.

Erlic Z, Neumann HP
Hormones (Athens) 2009 Jan-Mar;8(1):29-38. doi: 10.14310/horm.2002.1219. PMID: 19269919

Multiple endocrine neoplasia.

Caruso DR, O'Dorisio TM, Mazzaferri EL
Curr Opin Oncol 1991 Feb;3(1):103-8. doi: 10.1097/00001622-199102000-00015. PMID: 1675123

See all (196)

Diagnosis

Anesthesia for Endocrine Emergencies.

Peramunage D, Nikravan S
Anesthesiol Clin 2020 Mar;38(1):149-163. Epub 2020 Jan 2 doi: 10.1016/j.anclin.2019.10.006. PMID: 32008649

Applications of Immunohistochemistry to Endocrine Pathology.

Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042

Surgical approaches in hereditary endocrine tumors.

Iacobone M, Citton M, Viel G, Schiavone D, Torresan F
Updates Surg 2017 Jun;69(2):181-191. Epub 2017 Apr 28 doi: 10.1007/s13304-017-0451-y. PMID: 28455835

Thyroid-associated paragangliomas.

Phitayakorn R, Faquin W, Wei N, Barbesino G, Stephen AE
Thyroid 2011 Jul;21(7):725-33. Epub 2011 May 26 doi: 10.1089/thy.2010.0362. PMID: 21615305

Familial pheochromocytoma.

Erlic Z, Neumann HP
Hormones (Athens) 2009 Jan-Mar;8(1):29-38. doi: 10.14310/horm.2002.1219. PMID: 19269919

See all (456)

Therapy

Immunotherapy for endocrine tumours: a clinician's perspective.

Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757

The role of an anti-diabetic drug metformin in the treatment of endocrine tumors.

Thakur S, Daley B, Klubo-Gwiezdzinska J
J Mol Endocrinol 2019 Aug;63(2):R17-R35. doi: 10.1530/JME-19-0083. PMID: 31307011 Free PMC Article

Theranostics: evolution of the radiopharmaceutical meta-iodobenzylguanidine in endocrine tumors.

Sisson JC, Yanik GA
Semin Nucl Med 2012 May;42(3):171-84. doi: 10.1053/j.semnuclmed.2011.11.004. PMID: 22475426

Endocrine oncology in pregnancy.

Lansdown A, Rees DA
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):911-26. doi: 10.1016/j.beem.2011.06.011. PMID: 22115166

Imaging of neuroendocrine tumors.

Rufini V, Calcagni ML, Baum RP
Semin Nucl Med 2006 Jul;36(3):228-47. doi: 10.1053/j.semnuclmed.2006.03.007. PMID: 16762613

See all (73)

Prognosis

Immunotherapy for endocrine tumours: a clinician's perspective.

Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757

Phakomatoses and Endocrine Gland Tumors: Noteworthy and (Not so) Rare Associations.

Applications of Immunohistochemistry to Endocrine Pathology.

Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042

Endocrine oncology in pregnancy.

Lansdown A, Rees DA
Best Pract Res Clin Endocrinol Metab 2011 Dec;25(6):911-26. doi: 10.1016/j.beem.2011.06.011. PMID: 22115166

Familial pheochromocytoma.

Bissada MA, Safwat AS, Seyam RM, Al Sobhi S, Hanash KA, Bissada NK
Urol Oncol 2008 Jul-Aug;26(4):361-3. Epub 2007 Dec 21 doi: 10.1016/j.urolonc.2007.03.025. PMID: 18367101

See all (144)

Clinical prediction guides

Updates on the genetics of multiple endocrine neoplasia.

Sahakian N, Castinetti F, Romanet P, Reznik Y, Brue T
Ann Endocrinol (Paris) 2024 Apr;85(2):127-135. Epub 2024 Feb 5 doi: 10.1016/j.ando.2023.11.005. PMID: 38325596

Immunotherapy for endocrine tumours: a clinician's perspective.

Angelousi A, Tzoulis P, Tsoli M, Chatzellis E, Koumarianou A, Kaltsas G
Endocr Relat Cancer 2024 Apr 1;31(4) Epub 2024 Feb 12 doi: 10.1530/ERC-23-0296. PMID: 38235757

Update on C-Cell Neuroendocrine Neoplasm: Prognostic and Predictive Histopathologic and Molecular Features of Medullary Thyroid Carcinoma.

Jung CK, Agarwal S, Hang JF, Lim DJ, Bychkov A, Mete O
Endocr Pathol 2023 Mar;34(1):1-22. Epub 2023 Mar 8 doi: 10.1007/s12022-023-09753-5. PMID: 36890425

Applications of Immunohistochemistry to Endocrine Pathology.

Higgins SE, Barletta JA
Adv Anat Pathol 2018 Nov;25(6):413-429. doi: 10.1097/PAP.0000000000000209. PMID: 30157042

Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma.

Bílek R, Zelinka T, Vlček P, Dušková J, Michalský D, Novák K, Václavíková E, Widimský J Jr
Physiol Res 2017 Sep 26;66(Suppl 3):S397-S408. doi: 10.33549/physiolres.933719. PMID: 28948824

See all (109)

Recent systematic reviews

Adrenal Medullary Hyperplasia: A Systematic Review and Meta-analysis.

Ganni R, Torpy DJ, Falhammar H, Louise Rushworth R
J Clin Endocrinol Metab 2023 Aug 18;108(9):e885-e892. doi: 10.1210/clinem/dgad121. PMID: 36896586 Free PMC Article

Thyroid paraganglioma: A case-based systematic review of literature.

Mishra P, Padhi S, Behera G
J Cancer Res Ther 2020 Dec;16(Supplement):S11-S21. doi: 10.4103/jcrt.JCRT_713_18. PMID: 33380646

Ki67 in endocrine neoplasms: to count or not to count, this is the question! A systematic review from the English language literature.

Guadagno E, D'Avella E, Cappabianca P, Colao A, Del Basso De Caro M
J Endocrinol Invest 2020 Oct;43(10):1429-1445. Epub 2020 May 15 doi: 10.1007/s40618-020-01275-9. PMID: 32415572

Thyroid Paraganglioma: Our Experience and Systematic Review of the Literature on a Rare Tumor.

Pelizzo MR, Conti C, Pennelli G, Bellan E, Cook GJ, Wong KK, Colletti PM, Merante Boschin I, Rubello D
Am J Clin Oncol 2018 Apr;41(4):416-423. doi: 10.1097/COC.0000000000000295. PMID: 27163832

Efficacy and Safety of Everolimus in Extrapancreatic Neuroendocrine Tumor: A Comprehensive Review of Literature.

Faggiano A, Malandrino P, Modica R, Agrimi D, Aversano M, Bassi V, Giordano EA, Guarnotta V, Logoluso FA, Messina E, Nicastro V, Nuzzo V, Sciaraffia M, Colao A
Oncologist 2016 Jul;21(7):875-86. Epub 2016 Apr 6 doi: 10.1634/theoncologist.2015-0420. PMID: 27053503 Free PMC Article

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Thyroid Gland Paraganglioma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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