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Nasopharyngeal Basaloid Carcinoma

MedGen UID:
328304
•Concept ID:
C1711232
•
Neoplastic Process
Synonym: Nasopharyngeal Basaloid Squamous Cell Carcinoma

Definition

An aggressive variant of squamous cell carcinoma that arises from the nasopharynx. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNasopharyngeal Basaloid Carcinoma

Professional guidelines

PubMed

The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.
Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article

Recent clinical studies

Etiology

Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study.
Ogun GO, Olusanya AA, Akinmoladun VI, Adeyemo AA, Ogunkeyede SA, Daniel A, Awosusi BL, Fatunla EO, Fasunla AJ, Onakoya PA, Adeosun AA, Nwaorgu OG
Pan Afr Med J 2020;36:82. Epub 2020 Jun 9 doi: 10.11604/pamj.2020.36.82.19657. PMID: 32774641Free PMC Article
The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.
Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor.
Unsal AA, Booth JR, Rossi NA, Byrd JK, Kountakis SE
Laryngoscope 2019 Dec;129(12):2727-2732. Epub 2019 Jan 10 doi: 10.1002/lary.27788. PMID: 30632158
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879
Basaloid squamous cell carcinoma of the head and neck.
Paulino AF, Singh B, Shah JP, Huvos AG
Laryngoscope 2000 Sep;110(9):1479-82. doi: 10.1097/00005537-200009000-00013. PMID: 10983946

Diagnosis

Basaloid Nasopharyngeal Carcinoma: An Entity That Remains Oblivious.
Ganeson SK, Saniasiaya J, Mohamad I, Abdul Gani N
Gulf J Oncolog 2020 Sep;1(34):83-86. PMID: 33431368
Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study.
Ogun GO, Olusanya AA, Akinmoladun VI, Adeyemo AA, Ogunkeyede SA, Daniel A, Awosusi BL, Fatunla EO, Fasunla AJ, Onakoya PA, Adeosun AA, Nwaorgu OG
Pan Afr Med J 2020;36:82. Epub 2020 Jun 9 doi: 10.11604/pamj.2020.36.82.19657. PMID: 32774641Free PMC Article
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor.
Unsal AA, Booth JR, Rossi NA, Byrd JK, Kountakis SE
Laryngoscope 2019 Dec;129(12):2727-2732. Epub 2019 Jan 10 doi: 10.1002/lary.27788. PMID: 30632158
Poorly differentiated sinonasal tract malignancies: A review focusing on recently described entities.
Agaimy A
Cesk Patol 2016;52(3):146-53. PMID: 27526015
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
The importance of adjuvant treatment and primary anatomical site in head and neck basaloid squamous cell carcinoma survival: an analysis of the National Cancer Database.
Gootee J, Patel M, Aurit S, Silberstein P
Clin Transl Oncol 2020 Dec;22(12):2264-2274. Epub 2020 May 21 doi: 10.1007/s12094-020-02370-2. PMID: 32440914
Basaloid nasopharyngeal carcinoma: A population-based analysis of a rare tumor.
Unsal AA, Booth JR, Rossi NA, Byrd JK, Kountakis SE
Laryngoscope 2019 Dec;129(12):2727-2732. Epub 2019 Jan 10 doi: 10.1002/lary.27788. PMID: 30632158
Poorly differentiated sinonasal tract malignancies: A review focusing on recently described entities.
Agaimy A
Cesk Patol 2016;52(3):146-53. PMID: 27526015
Basaloid squamous cell carcinoma of the head and neck: location means everything.
Fritsch VA, Lentsch EJ
J Surg Oncol 2014 May;109(6):616-22. Epub 2014 Jan 24 doi: 10.1002/jso.23536. PMID: 24464879

Clinical prediction guides

Histological subtype remains a prognostic factor for survival in nasopharyngeal carcinoma patients.
Pan XX, Liu YJ, Yang W, Chen YF, Tang WB, Li CR
Laryngoscope 2020 Mar;130(3):E83-E88. Epub 2019 Jun 12 doi: 10.1002/lary.28099. PMID: 31188486
Utility of p40 in the Differential Diagnosis of Small Round Blue Cell Tumors of the Sinonasal Tract.
Tilson MP, Bishop JA
Head Neck Pathol 2014 Jun;8(2):141-5. Epub 2013 Oct 11 doi: 10.1007/s12105-013-0496-2. PMID: 24114197Free PMC Article
Atypical squamous cell carcinoma of the larynx and hypopharynx: radiologic features and pathologic correlation.
Becker M, Moulin G, Kurt AM, Zbären P, Dulgerov P, Marchal F, Zanaret P, Lehmann W, Rüfenacht DA, Terrier F
Eur Radiol 1998;8(9):1541-51. doi: 10.1007/s003300050584. PMID: 9866759

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