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Lithium transport

MedGen UID:
331956
•Concept ID:
C1835356
•
Finding
Synonym: LITHIUM TRANSPORT
 
Monarch Initiative: MONDO:0007912
OMIM®: 152420

Clinical features

From HPO
Bipolar affective disorder
MedGen UID:
2649
•Concept ID:
C0005586
•
Mental or Behavioral Dysfunction
Bipolar disorder is an illness of mood characterized by alternating episodes of elevated and depressed moods, which are interspersed with euthymic periods.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Low rate of membrane lithium transport during treatment correlates with outcome of maintenance pharmacotherapy in bipolar disorder.
Mallinger AG, Frank E, Thase ME, Dippold CS, Kupfer DJ
Neuropsychopharmacology 1997 May;16(5):325-32. doi: 10.1016/S0893-133X(96)00241-2. PMID: 9109103
Erythrocyte lithium transport during lithium treatment in patients with affective disorders.
Zaremba D, Rybakowski J
Pharmacopsychiatry 1986 Mar;19(2):63-7. doi: 10.1055/s-2007-1017156. PMID: 3085111
Effect of combined haloperidol-lithium treatment on vitro RBC lithium uptake in patients with affective disorders.
Werstiuk ES, Grof P, Rotstein E, Werner L
Prog Neuropsychopharmacol Biol Psychiatry 1983;7(4-6):831-4. doi: 10.1016/0278-5846(83)90077-5. PMID: 6686715

Recent clinical studies

Etiology

Controversies surrounding erythrocyte sodium-lithium countertransport.
Hardman TC, Lant AF
J Hypertens 1996 Jun;14(6):695-703. doi: 10.1097/00004872-199606000-00004. PMID: 8793691
Sodium-lithium transport in adolescents with IDDM. Relationship to incipient nephropathy and glycemic control.
Crompton CH, Balfe JW, Balfe JA, Chatzilias A, Daneman D
Diabetes Care 1994 Jul;17(7):704-10. doi: 10.2337/diacare.17.7.704. PMID: 7924781
Effect of lithium and neuroleptic combination on lithium transport, blood pressure, and weight in bipolar patients.
Ghadirian AM, Nair NP, Schwartz G
Biol Psychiatry 1989 Jun;26(2):139-44. doi: 10.1016/0006-3223(89)90017-6. PMID: 2736263
Lithium transport in human fibroblasts: relationship to RBC lithium transport and psychiatric diagnoses.
Hitzemann R, Kao L, Hirschowitz J, Garver D, Gruenstein E
Psychiatry Res 1988 Jun;24(3):337-44. doi: 10.1016/0165-1781(88)90114-x. PMID: 2841710
Essential hypertension and membrane lithium transport in depressed patients.
Mallinger AG, Mallinger J, Himmelhoch JM, Rossi A, Hanin I
Psychiatry Res 1983 Sep;10(1):11-6. doi: 10.1016/0165-1781(83)90023-9. PMID: 6580654

Diagnosis

A half-century of participant observation in psychiatry. Part II: Affective disorders.
Rybakowski J
Psychiatr Pol 2020 Aug 31;54(4):641-659. doi: 10.12740/PP/123167. PMID: 33386718
Empagliflozin-Mediated Lithium Excretion: A Case Study and Clinical Applications.
Armstrong GP
Am J Case Rep 2020 Jun 10;21:e923311. doi: 10.12659/AJCR.923311. PMID: 32518219Free PMC Article
Lithium poisoning: is determination of the red blood cell lithium concentration useful?
El Balkhi S, Megarbane B, Poupon J, Baud FJ, Galliot-Guilley M
Clin Toxicol (Phila) 2009 Jan;47(1):8-13. doi: 10.1080/15563650802392398. PMID: 18821095
EEG sleep, lithium transport, dexamethasone suppression, and monoamine oxidase activity in borderline personality disorder.
Lahmeyer HW, Val E, Gaviria FM, Prasad RB, Pandey GN, Rodgers P, Weiler MA, Altman EG
Psychiatry Res 1988 Jul;25(1):19-30. doi: 10.1016/0165-1781(88)90154-0. PMID: 3217463
Lithium transport in human fibroblasts: relationship to RBC lithium transport and psychiatric diagnoses.
Hitzemann R, Kao L, Hirschowitz J, Garver D, Gruenstein E
Psychiatry Res 1988 Jun;24(3):337-44. doi: 10.1016/0165-1781(88)90114-x. PMID: 2841710

Therapy

A half-century of participant observation in psychiatry. Part II: Affective disorders.
Rybakowski J
Psychiatr Pol 2020 Aug 31;54(4):641-659. doi: 10.12740/PP/123167. PMID: 33386718
Empagliflozin-Mediated Lithium Excretion: A Case Study and Clinical Applications.
Armstrong GP
Am J Case Rep 2020 Jun 10;21:e923311. doi: 10.12659/AJCR.923311. PMID: 32518219Free PMC Article
Lithium poisoning: is determination of the red blood cell lithium concentration useful?
El Balkhi S, Megarbane B, Poupon J, Baud FJ, Galliot-Guilley M
Clin Toxicol (Phila) 2009 Jan;47(1):8-13. doi: 10.1080/15563650802392398. PMID: 18821095
Dissimilar effects of lithium and carbamazepine on erythrocyte lithium transport in vivo: clinical implications.
Rybakowski J, Lehmann W, Matkowski K
Pol J Pharmacol Pharm 1990 Mar-Apr;42(2):113-20. PMID: 2274469
Erythrocyte lithium transport during lithium treatment in patients with affective disorders.
Zaremba D, Rybakowski J
Pharmacopsychiatry 1986 Mar;19(2):63-7. doi: 10.1055/s-2007-1017156. PMID: 3085111

Prognosis

Lithium poisoning: is determination of the red blood cell lithium concentration useful?
El Balkhi S, Megarbane B, Poupon J, Baud FJ, Galliot-Guilley M
Clin Toxicol (Phila) 2009 Jan;47(1):8-13. doi: 10.1080/15563650802392398. PMID: 18821095
Low rate of membrane lithium transport during treatment correlates with outcome of maintenance pharmacotherapy in bipolar disorder.
Mallinger AG, Frank E, Thase ME, Dippold CS, Kupfer DJ
Neuropsychopharmacology 1997 May;16(5):325-32. doi: 10.1016/S0893-133X(96)00241-2. PMID: 9109103
An attempt to predict daily erythrocyte lithium fluctuations.
Sögüt O, Yalçinkaya C, Saygili R, Tuglular I, Kayali A
Eur J Drug Metab Pharmacokinet 1995 Oct-Dec;20(4):271-4. doi: 10.1007/BF03190243. PMID: 8983931
Sodium-lithium transport in adolescents with IDDM. Relationship to incipient nephropathy and glycemic control.
Crompton CH, Balfe JW, Balfe JA, Chatzilias A, Daneman D
Diabetes Care 1994 Jul;17(7):704-10. doi: 10.2337/diacare.17.7.704. PMID: 7924781
A heritable disorder of lithium transport in erythrocytes of a subpopulation of manic-depressive patients.
Ostrow DG, Pandey GN, Davis JM, Hurt SW, Tosteson DC
Am J Psychiatry 1978 Sep;135(9):1070-8. doi: 10.1176/ajp.135.9.1070. PMID: 696928

Clinical prediction guides

A half-century of participant observation in psychiatry. Part II: Affective disorders.
Rybakowski J
Psychiatr Pol 2020 Aug 31;54(4):641-659. doi: 10.12740/PP/123167. PMID: 33386718
Lithium poisoning: is determination of the red blood cell lithium concentration useful?
El Balkhi S, Megarbane B, Poupon J, Baud FJ, Galliot-Guilley M
Clin Toxicol (Phila) 2009 Jan;47(1):8-13. doi: 10.1080/15563650802392398. PMID: 18821095
Controversies surrounding erythrocyte sodium-lithium countertransport.
Hardman TC, Lant AF
J Hypertens 1996 Jun;14(6):695-703. doi: 10.1097/00004872-199606000-00004. PMID: 8793691
Abnormalities of lithium transport across the erythrocyte membrane in depression and schizophrenia.
Rybakowski JK, Lehmann W
Biol Psychiatry 1991 Feb 15;29(4):340-6. doi: 10.1016/0006-3223(91)90219-c. PMID: 2036477
Evaluation of lithium clearance as a marker of proximal tubule sodium handling.
Koomans HA, Boer WH, Dorhout Mees EJ
Kidney Int 1989 Jul;36(1):2-12. doi: 10.1038/ki.1989.153. PMID: 2681925

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