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Coronary artery disease, susceptibility to

MedGen UID:
333498
•Concept ID:
C1840169
•
Finding
Synonym: CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO
 
OMIM®: 147545; 168820

Clinical features

From HPO
Abnormality of metabolism/homeostasis
MedGen UID:
867398
•Concept ID:
C4021768
•
Finding
See: Feature record | Search on this feature

Professional guidelines

PubMed

Associations of P2Y12R gene polymorphisms with susceptibility to coronary heart disease and clinical efficacy of antiplatelet treatment with clopidogrel.
Yang HH, Chen Y, Gao CY
Cardiovasc Ther 2016 Dec;34(6):460-467. doi: 10.1111/1755-5922.12223. PMID: 27566695
Quantitative assessment of the influence of PSMA6 variant (rs1048990) on coronary artery disease risk.
Wang H, Jiang M, Zhu H, Chen Q, Gong P, Lin J, Lu J, Qiu J
Mol Biol Rep 2013 Feb;40(2):1035-41. Epub 2012 Oct 31 doi: 10.1007/s11033-012-2146-2. PMID: 23111455
Translating genomic analyses into improved management of coronary artery disease.
Johansen CT, Lanktree MB, Hegele RA
Future Cardiol 2010 Jul;6(4):507-21. doi: 10.2217/fca.10.28. PMID: 20608823

Recent clinical studies

Etiology

Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Effects of Coronary Artery Disease-Associated Variants on Vascular Smooth Muscle Cells.
Solomon CU, McVey DG, Andreadi C, Gong P, Turner L, Stanczyk PJ, Khemiri S, Chamberlain JC, Yang W, Webb TR, Nelson CP, Samani NJ, Ye S
Circulation 2022 Sep 20;146(12):917-929. Epub 2022 Jun 23 doi: 10.1161/CIRCULATIONAHA.121.058389. PMID: 35735005Free PMC Article
Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches.
Medina-Leyte DJ, Zepeda-García O, Domínguez-Pérez M, González-Garrido A, Villarreal-Molina T, Jacobo-Albavera L
Int J Mol Sci 2021 Apr 8;22(8) doi: 10.3390/ijms22083850. PMID: 33917744Free PMC Article
Screening and Risk Assessment of Coronary Artery Disease in Patients With Type 2 Diabetes: An Updated Review.
Patsouras A, Farmaki P, Garmpi A, Damaskos C, Garmpis N, Mantas D, Diamantis E
In Vivo 2019 Jul-Aug;33(4):1039-1049. doi: 10.21873/invivo.11572. PMID: 31280191Free PMC Article
A review on coronary artery disease, its risk factors, and therapeutics.
Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S
J Cell Physiol 2019 Aug;234(10):16812-16823. Epub 2019 Feb 20 doi: 10.1002/jcp.28350. PMID: 30790284

Diagnosis

Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction.
Nurmohamed NS, Kraaijenhof JM, Mayr M, Nicholls SJ, Koenig W, Catapano AL, Stroes ESG
Eur Heart J 2023 May 7;44(18):1594-1607. doi: 10.1093/eurheartj/ehad161. PMID: 36988179Free PMC Article
Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study.
Liu HM, Zhang Q, Shen WD, Li BY, Lv WQ, Xiao HM, Deng HW
Aging (Albany NY) 2020 Feb 16;12(4):3340-3353. doi: 10.18632/aging.102815. PMID: 32062614Free PMC Article
Screening and Risk Assessment of Coronary Artery Disease in Patients With Type 2 Diabetes: An Updated Review.
Patsouras A, Farmaki P, Garmpi A, Damaskos C, Garmpis N, Mantas D, Diamantis E
In Vivo 2019 Jul-Aug;33(4):1039-1049. doi: 10.21873/invivo.11572. PMID: 31280191Free PMC Article
A review on coronary artery disease, its risk factors, and therapeutics.
Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S
J Cell Physiol 2019 Aug;234(10):16812-16823. Epub 2019 Feb 20 doi: 10.1002/jcp.28350. PMID: 30790284

Therapy

Relationship between NAFLD and coronary artery disease: A Mendelian randomization study.
Ren Z, Simons PIHG, Wesselius A, Stehouwer CDA, Brouwers MCGJ
Hepatology 2023 Jan 1;77(1):230-238. Epub 2022 May 18 doi: 10.1002/hep.32534. PMID: 35441719Free PMC Article
Effects of Coronary Artery Disease-Associated Variants on Vascular Smooth Muscle Cells.
Solomon CU, McVey DG, Andreadi C, Gong P, Turner L, Stanczyk PJ, Khemiri S, Chamberlain JC, Yang W, Webb TR, Nelson CP, Samani NJ, Ye S
Circulation 2022 Sep 20;146(12):917-929. Epub 2022 Jun 23 doi: 10.1161/CIRCULATIONAHA.121.058389. PMID: 35735005Free PMC Article
Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study.
Frerich S, Malik R, Georgakis MK, Sinner MF, Kittner SJ, Mitchell BD, Dichgans M
Stroke 2022 Apr;53(4):e130-e135. Epub 2021 Dec 16 doi: 10.1161/STROKEAHA.121.036306. PMID: 34911345Free PMC Article
Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study.
Liu HM, Zhang Q, Shen WD, Li BY, Lv WQ, Xiao HM, Deng HW
Aging (Albany NY) 2020 Feb 16;12(4):3340-3353. doi: 10.18632/aging.102815. PMID: 32062614Free PMC Article
Sleep Duration and Myocardial Infarction.
Daghlas I, Dashti HS, Lane J, Aragam KG, Rutter MK, Saxena R, Vetter C
J Am Coll Cardiol 2019 Sep 10;74(10):1304-1314. doi: 10.1016/j.jacc.2019.07.022. PMID: 31488267Free PMC Article

Prognosis

Coronary Artery Calcification: Current Concepts and Clinical Implications.
Onnis C, Virmani R, Kawai K, Nardi V, Lerman A, Cademartiri F, Scicolone R, Boi A, Congiu T, Faa G, Libby P, Saba L
Circulation 2024 Jan 16;149(3):251-266. doi: 10.1161/CIRCULATIONAHA.123.065657. PMID: 38227718Free PMC Article
Relationship between NAFLD and coronary artery disease: A Mendelian randomization study.
Ren Z, Simons PIHG, Wesselius A, Stehouwer CDA, Brouwers MCGJ
Hepatology 2023 Jan 1;77(1):230-238. Epub 2022 May 18 doi: 10.1002/hep.32534. PMID: 35441719Free PMC Article
Sarcopenia-related traits and coronary artery disease: a bi-directional Mendelian randomization study.
Liu HM, Zhang Q, Shen WD, Li BY, Lv WQ, Xiao HM, Deng HW
Aging (Albany NY) 2020 Feb 16;12(4):3340-3353. doi: 10.18632/aging.102815. PMID: 32062614Free PMC Article
Screening and Risk Assessment of Coronary Artery Disease in Patients With Type 2 Diabetes: An Updated Review.
Patsouras A, Farmaki P, Garmpi A, Damaskos C, Garmpis N, Mantas D, Diamantis E
In Vivo 2019 Jul-Aug;33(4):1039-1049. doi: 10.21873/invivo.11572. PMID: 31280191Free PMC Article
Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study.
Said MA, Verweij N, van der Harst P
JAMA Cardiol 2018 Aug 1;3(8):693-702. doi: 10.1001/jamacardio.2018.1717. PMID: 29955826Free PMC Article

Clinical prediction guides

Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study.
Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y, Lu S, Aledan AKO, Wang Y, Wang Z
J Am Heart Assoc 2023 Jun 20;12(12):e029689. Epub 2023 Jun 10 doi: 10.1161/JAHA.123.029689. PMID: 37301769Free PMC Article
Proteomics and lipidomics in atherosclerotic cardiovascular disease risk prediction.
Nurmohamed NS, Kraaijenhof JM, Mayr M, Nicholls SJ, Koenig W, Catapano AL, Stroes ESG
Eur Heart J 2023 May 7;44(18):1594-1607. doi: 10.1093/eurheartj/ehad161. PMID: 36988179Free PMC Article
Polygenic risk scores for the prediction of cardiometabolic disease.
O'Sullivan JW, Ashley EA, Elliott PM
Eur Heart J 2023 Jan 7;44(2):89-99. doi: 10.1093/eurheartj/ehac648. PMID: 36478054
Effects of Coronary Artery Disease-Associated Variants on Vascular Smooth Muscle Cells.
Solomon CU, McVey DG, Andreadi C, Gong P, Turner L, Stanczyk PJ, Khemiri S, Chamberlain JC, Yang W, Webb TR, Nelson CP, Samani NJ, Ye S
Circulation 2022 Sep 20;146(12):917-929. Epub 2022 Jun 23 doi: 10.1161/CIRCULATIONAHA.121.058389. PMID: 35735005Free PMC Article
Screening and Risk Assessment of Coronary Artery Disease in Patients With Type 2 Diabetes: An Updated Review.
Patsouras A, Farmaki P, Garmpi A, Damaskos C, Garmpis N, Mantas D, Diamantis E
In Vivo 2019 Jul-Aug;33(4):1039-1049. doi: 10.21873/invivo.11572. PMID: 31280191Free PMC Article

Recent systematic reviews

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.
Gill D, Cameron AC, Burgess S, Li X, Doherty DJ, Karhunen V, Abdul-Rahim AH, Taylor-Rowan M, Zuber V, Tsao PS, Klarin D; VA Million Veteran Program, Evangelou E, Elliott P, Damrauer SM, Quinn TJ, Dehghan A, Theodoratou E, Dawson J, Tzoulaki I
Hypertension 2021 Feb;77(2):383-392. Epub 2020 Dec 28 doi: 10.1161/HYPERTENSIONAHA.120.16547. PMID: 33356394Free PMC Article
Rs10757274 gene polymorphisms in coronary artery disease: A systematic review and a meta-analysis.
Xu LB, Zhang YQ, Zhang NN, Li B, Weng JY, Li XY, Lu WC, Yu PR, Wang X, Li Y, Han Z, Chen L, He HT, Zhou YF, Ma XX, Xu GD
Medicine (Baltimore) 2020 Jan;99(3):e18841. doi: 10.1097/MD.0000000000018841. PMID: 32011499Free PMC Article
Human cytomegalovirus infection and coronary heart disease: a systematic review.
Du Y, Zhang G, Liu Z
Virol J 2018 Feb 6;15(1):31. doi: 10.1186/s12985-018-0937-3. PMID: 29409508Free PMC Article
Common Variants of Vitamin D Receptor Gene Polymorphisms and Susceptibility to Coronary Artery Disease: A Systematic Review and Meta-Analysis.
Alizadeh S, Djafarian K, Alizadeh H, Mohseni R, Shab-Bidar S
J Nutrigenet Nutrigenomics 2017;10(1-2):9-18. Epub 2017 Mar 29 doi: 10.1159/000455914. PMID: 28351026
Human Validation of Genes Associated With a Murine Atherosclerotic Phenotype.
Pasterkamp G, van der Laan SW, Haitjema S, Foroughi Asl H, Siemelink MA, Bezemer T, van Setten J, Dichgans M, Malik R, Worrall BB, Schunkert H, Samani NJ, de Kleijn DP, Markus HS, Hoefer IE, Michoel T, de Jager SC, Björkegren JL, den Ruijter HM, Asselbergs FW
Arterioscler Thromb Vasc Biol 2016 Jun;36(6):1240-6. Epub 2016 Apr 14 doi: 10.1161/ATVBAHA.115.306958. PMID: 27079880

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