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Increased retinal vascularity

MedGen UID:
336208
•Concept ID:
C1847882
•
Finding
HPO: HP:0007986

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased retinal vascularity

Conditions with this feature

PHACE syndrome
MedGen UID:
376231
•Concept ID:
C1847874
•
Disease or Syndrome
PHACE is an acronym for a neurocutaneous syndrome encompassing the following features: posterior fossa brain malformations, hemangiomas of the face (large or complex), arterial anomalies, cardiac anomalies, and eye abnormalities. The association is referred to as PHACES when ventral developmental defects, such as sternal clefting or supraumbilical raphe, are present (summary by Bracken et al., 2011).
See: Condition Record
PHACE syndrome

Professional guidelines

PubMed

A review of neovascular glaucoma. Etiopathogenesis and treatment.
Dumbrăveanu L, Cușnir V, Bobescu D
Rom J Ophthalmol 2021 Oct-Dec;65(4):315-329. doi: 10.22336/rjo.2021.66. PMID: 35087972Free PMC Article
Diabetic macular edema: Evidence-based management.
Browning DJ, Stewart MW, Lee C
Indian J Ophthalmol 2018 Dec;66(12):1736-1750. doi: 10.4103/ijo.IJO_1240_18. PMID: 30451174Free PMC Article
Guidelines for the Management of Diabetic Macular Edema by the European Society of Retina Specialists (EURETINA).
Schmidt-Erfurth U, Garcia-Arumi J, Bandello F, Berg K, Chakravarthy U, Gerendas BS, Jonas J, Larsen M, Tadayoni R, Loewenstein A
Ophthalmologica 2017;237(4):185-222. Epub 2017 Apr 20 doi: 10.1159/000458539. PMID: 28423385

Recent clinical studies

Etiology

Retinal Microvasculature: A Potential Window Into Heart Failure Prevention.
Chaikijurajai T, Ehlers JP, Tang WHW
JACC Heart Fail 2022 Nov;10(11):785-791. Epub 2022 Sep 7 doi: 10.1016/j.jchf.2022.07.004. PMID: 36328644
Visuopathy of prematurity: is retinopathy just the tip of the iceberg?
Ingvaldsen SH, Morken TS, Austeng D, Dammann O
Pediatr Res 2022 Apr;91(5):1043-1048. Epub 2021 Jun 24 doi: 10.1038/s41390-021-01625-0. PMID: 34168272Free PMC Article
Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Retinal Vascular Signs and Cerebrovascular Diseases.
Rim TH, Teo AWJ, Yang HHS, Cheung CY, Wong TY
J Neuroophthalmol 2020 Mar;40(1):44-59. doi: 10.1097/WNO.0000000000000888. PMID: 31977663
Somatolactogens and diabetic retinopathy.
Bermea KC, Rodríguez-García A, Tsin A, Barrera-Saldaña HA
Growth Horm IGF Res 2018 Aug;41:42-47. Epub 2018 Feb 6 doi: 10.1016/j.ghir.2018.02.002. PMID: 29452885

Diagnosis

Vascular abnormalities in uveitis.
Ebrahimiadib N, Maleki A, Fadakar K, Manhapra A, Ghassemi F, Foster CS
Surv Ophthalmol 2021 Jul-Aug;66(4):653-667. Epub 2021 Jan 5 doi: 10.1016/j.survophthal.2020.12.006. PMID: 33412171
Pathogenesis of ocular toxoplasmosis.
Smith JR, Ashander LM, Arruda SL, Cordeiro CA, Lie S, Rochet E, Belfort R Jr, Furtado JM
Prog Retin Eye Res 2021 Mar;81:100882. Epub 2020 Jul 24 doi: 10.1016/j.preteyeres.2020.100882. PMID: 32717377
Proteomic Biomarkers of Retinal Inflammation in Diabetic Retinopathy.
Youngblood H, Robinson R, Sharma A, Sharma S
Int J Mol Sci 2019 Sep 25;20(19) doi: 10.3390/ijms20194755. PMID: 31557880Free PMC Article
RETINAL CAPILLARY MACROANEURYSMS.
Spaide RF, Barquet LA
Retina 2019 Oct;39(10):1889-1895. doi: 10.1097/IAE.0000000000002406. PMID: 30489449
NEOVASCULAR SECONDARY GLAUCOMA, ETIOLOGY AND PATHOGENESIS.
Barac IR, Pop MD, Gheorghe AI, Taban C
Rom J Ophthalmol 2015 Jan-Mar;59(1):24-8. PMID: 27373111Free PMC Article

Therapy

A Linkage between Angiogenesis and Inflammation in Neovascular Age-Related Macular Degeneration.
Heloterä H, Kaarniranta K
Cells 2022 Nov 1;11(21) doi: 10.3390/cells11213453. PMID: 36359849Free PMC Article
Updates on sphingolipids: Spotlight on retinopathy.
Shiwani HA, Elfaki MY, Memon D, Ali S, Aziz A, Egom EE
Biomed Pharmacother 2021 Nov;143:112197. Epub 2021 Sep 21 doi: 10.1016/j.biopha.2021.112197. PMID: 34560541
Retinal and choroidal vascularity changes in healthcare professionals wearing FFP3 respirators.
Yildiz MB, Balci S, Özçelik Köse A, Yenerel NM, Yildiz HE
Cutan Ocul Toxicol 2021 Jun;40(2):70-77. Epub 2021 Mar 15 doi: 10.1080/15569527.2021.1900218. PMID: 33719844
Thrombosis and Hemorrhage in Diabetic Retinopathy: A Perspective from an Inflammatory Standpoint.
Murugesan N, Üstunkaya T, Feener EP
Semin Thromb Hemost 2015 Sep;41(6):659-64. Epub 2015 Aug 25 doi: 10.1055/s-0035-1556731. PMID: 26305236Free PMC Article
Ranibizumab for diabetic retinopathy.
Rodriguez-Fontal M, Alfaro V, Kerrison JB, Jablon EP
Curr Diabetes Rev 2009 Feb;5(1):47-51. doi: 10.2174/157339909787314239. PMID: 19199898

Prognosis

Association of Retinal Age Gap With Arterial Stiffness and Incident Cardiovascular Disease.
Zhu Z, Chen Y, Wang W, Wang Y, Hu W, Shang X, Liao H, Shi D, Huang Y, Ha J, Tan Z, Kiburg KV, Zhang X, Tang S, Yu H, Yang X, He M
Stroke 2022 Nov;53(11):3320-3328. Epub 2022 Jul 26 doi: 10.1161/STROKEAHA.122.038809. PMID: 35880520
Risk of Inflammation, Retinal Vasculitis, and Retinal Occlusion-Related Events with Brolucizumab: Post Hoc Review of HAWK and HARRIER.
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Retinal Vascular Signs and Cerebrovascular Diseases.
Rim TH, Teo AWJ, Yang HHS, Cheung CY, Wong TY
J Neuroophthalmol 2020 Mar;40(1):44-59. doi: 10.1097/WNO.0000000000000888. PMID: 31977663
RETINAL CAPILLARY MACROANEURYSMS.
Spaide RF, Barquet LA
Retina 2019 Oct;39(10):1889-1895. doi: 10.1097/IAE.0000000000002406. PMID: 30489449
NEOVASCULAR SECONDARY GLAUCOMA, ETIOLOGY AND PATHOGENESIS.
Barac IR, Pop MD, Gheorghe AI, Taban C
Rom J Ophthalmol 2015 Jan-Mar;59(1):24-8. PMID: 27373111Free PMC Article

Clinical prediction guides

Endothelial function in cardiovascular medicine: a consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.
Alexander Y, Osto E, Schmidt-Trucksäss A, Shechter M, Trifunovic D, Duncker DJ, Aboyans V, Bäck M, Badimon L, Cosentino F, De Carlo M, Dorobantu M, Harrison DG, Guzik TJ, Hoefer I, Morris PD, Norata GD, Suades R, Taddei S, Vilahur G, Waltenberger J, Weber C, Wilkinson F, Bochaton-Piallat ML, Evans PC
Cardiovasc Res 2021 Jan 1;117(1):29-42. doi: 10.1093/cvr/cvaa085. PMID: 32282914Free PMC Article
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity.
Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt SM, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K
Circ Res 2020 Jul 31;127(4):466-482. Epub 2020 May 14 doi: 10.1161/CIRCRESAHA.119.316463. PMID: 32404031Free PMC Article
Retinal Vascular Signs and Cerebrovascular Diseases.
Rim TH, Teo AWJ, Yang HHS, Cheung CY, Wong TY
J Neuroophthalmol 2020 Mar;40(1):44-59. doi: 10.1097/WNO.0000000000000888. PMID: 31977663
RETINAL CAPILLARY MACROANEURYSMS.
Spaide RF, Barquet LA
Retina 2019 Oct;39(10):1889-1895. doi: 10.1097/IAE.0000000000002406. PMID: 30489449
Somatolactogens and diabetic retinopathy.
Bermea KC, Rodríguez-García A, Tsin A, Barrera-Saldaña HA
Growth Horm IGF Res 2018 Aug;41:42-47. Epub 2018 Feb 6 doi: 10.1016/j.ghir.2018.02.002. PMID: 29452885

Recent systematic reviews

Comparative Efficacy, Durability and Safety of Faricimab in the Treatment of Diabetic Macular Edema: A Systematic Literature Review and Network Meta-Analysis.
Watkins C, Paulo T, Bührer C, Holekamp NM, Bagijn M
Adv Ther 2023 Dec;40(12):5204-5221. Epub 2023 Sep 26 doi: 10.1007/s12325-023-02675-y. PMID: 37751021Free PMC Article
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.
Perais J, Agarwal R, Evans JR, Loveman E, Colquitt JL, Owens D, Hogg RE, Lawrenson JG, Takwoingi Y, Lois N
Cochrane Database Syst Rev 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. PMID: 36815723Free PMC Article
Global epidemiology of retinal vein occlusion: a systematic review and meta-analysis of prevalence, incidence, and risk factors.
Song P, Xu Y, Zha M, Zhang Y, Rudan I
J Glob Health 2019 Jun;9(1):010427. doi: 10.7189/jogh.09.010427. PMID: 31131101Free PMC Article
Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis.
Song P, Yu J, Chan KY, Theodoratou E, Rudan I
J Glob Health 2018 Jun;8(1):010803. doi: 10.7189/jogh.08.010803. PMID: 29899983Free PMC Article
Obesity and the microvasculature: a systematic review and meta-analysis.
Boillot A, Zoungas S, Mitchell P, Klein R, Klein B, Ikram MK, Klaver C, Wang JJ, Gopinath B, Tai ES, Neubauer AS, Hercberg S, Brazionis L, Saw SM, Wong TY, Czernichow S; META-EYE Study Group
PLoS One 2013;8(2):e52708. Epub 2013 Feb 6 doi: 10.1371/journal.pone.0052708. PMID: 23405065Free PMC Article

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    Clinical resources

    Practice guidelines

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