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Premature graying of body hair

MedGen UID:
341386
•Concept ID:
C1849125
•
Finding
Synonym: Premature greying of body hair
 
HPO: HP:0004771

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPremature graying of body hair

Conditions with this feature

Hereditary spastic paraplegia 23
MedGen UID:
167094
•Concept ID:
C0796019
•
Disease or Syndrome
Spastic paraplegia-23 (SPG23) is an autosomal recessive neurologic disorder characterized by childhood-onset spastic paraplegia resulting in gait difficulties and associated with pigmentary abnormalities, including premature graying of the hair and vitiligo-like or hyperpigmented skin lesions. Some patients may also have a peripheral neuropathy (summary by Lee et al., 2017).
See: Condition Record
Hereditary spastic paraplegia 23

Recent clinical studies

Etiology

Cardiovascular risk markers in premature canities.
Das S, Chander R, Garg T, Mendiratta V, Singh R, Sanke S
Indian J Dermatol Venereol Leprol 2023 Jan-Mar;89(2):221-225. doi: 10.25259/IJDVL_501_2021. PMID: 35841351
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Relationship between diet, atopy, family history, and premature hair graying.
Acer E, Kaya Erdoğan H, İğrek A, Parlak H, Saraçoğlu ZN, Bilgin M
J Cosmet Dermatol 2019 Apr;18(2):665-670. Epub 2018 Dec 16 doi: 10.1111/jocd.12840. PMID: 30556257
Association of premature hair graying with family history, smoking, and obesity: a cross-sectional study.
Shin H, Ryu HH, Yoon J, Jo S, Jang S, Choi M, Kwon O, Jo SJ
J Am Acad Dermatol 2015 Feb;72(2):321-7. Epub 2014 Dec 4 doi: 10.1016/j.jaad.2014.11.008. PMID: 25484268
Werner's syndrome.
Duvic M, Lemak NA
Dermatol Clin 1995 Jan;13(1):163-8. PMID: 7712642

Diagnosis

Cardiovascular risk markers in premature canities.
Das S, Chander R, Garg T, Mendiratta V, Singh R, Sanke S
Indian J Dermatol Venereol Leprol 2023 Jan-Mar;89(2):221-225. doi: 10.25259/IJDVL_501_2021. PMID: 35841351
Skin changes in the obese patient.
Hirt PA, Castillo DE, Yosipovitch G, Keri JE
J Am Acad Dermatol 2019 Nov;81(5):1037-1057. doi: 10.1016/j.jaad.2018.12.070. PMID: 31610857
Relationship between diet, atopy, family history, and premature hair graying.
Acer E, Kaya Erdoğan H, İğrek A, Parlak H, Saraçoğlu ZN, Bilgin M
J Cosmet Dermatol 2019 Apr;18(2):665-670. Epub 2018 Dec 16 doi: 10.1111/jocd.12840. PMID: 30556257
Dermatologic manifestations of ataxia-telangiectasia syndrome.
Greenberger S, Berkun Y, Ben-Zeev B, Levi YB, Barziliai A, Nissenkorn A
J Am Acad Dermatol 2013 Jun;68(6):932-6. Epub 2013 Jan 27 doi: 10.1016/j.jaad.2012.12.950. PMID: 23360865
Premature hair whitening is an independent predictor of carotid intima-media thickness in young and middle-aged men.
Erdoğan T, Kocaman SA, Çetin M, Durakoğlugil ME, Uğurlu Y, Şahin İ, Çanga A
Intern Med 2013;52(1):29-36. Epub 2013 Jan 1 doi: 10.2169/internalmedicine.52.7842. PMID: 23291671

Therapy

Relationship between diet, atopy, family history, and premature hair graying.
Acer E, Kaya Erdoğan H, İğrek A, Parlak H, Saraçoğlu ZN, Bilgin M
J Cosmet Dermatol 2019 Apr;18(2):665-670. Epub 2018 Dec 16 doi: 10.1111/jocd.12840. PMID: 30556257

Prognosis

Premature hair whitening is an independent predictor of carotid intima-media thickness in young and middle-aged men.
Erdoğan T, Kocaman SA, Çetin M, Durakoğlugil ME, Uğurlu Y, Şahin İ, Çanga A
Intern Med 2013;52(1):29-36. Epub 2013 Jan 1 doi: 10.2169/internalmedicine.52.7842. PMID: 23291671
The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age.
Kocaman SA, Çetin M, Durakoğlugil ME, Erdoğan T, Çanga A, Çiçek Y, Doğan S, Şahin I, Şatıroğlu O, Bostan M
Anadolu Kardiyol Derg 2012 Sep;12(6):457-63. Epub 2012 Jun 7 doi: 10.5152/akd.2012.150. PMID: 22677402
Cutaneous factors related to the risk of malignant melanoma.
Beral V, Evans S, Shaw H, Milton G
Br J Dermatol 1983 Aug;109(2):165-72. doi: 10.1111/j.1365-2133.1983.tb07077.x. PMID: 6871096

Clinical prediction guides

Relationship between diet, atopy, family history, and premature hair graying.
Acer E, Kaya Erdoğan H, İğrek A, Parlak H, Saraçoğlu ZN, Bilgin M
J Cosmet Dermatol 2019 Apr;18(2):665-670. Epub 2018 Dec 16 doi: 10.1111/jocd.12840. PMID: 30556257
Risk Factors for Premature Hair Graying in Young Turkish Adults.
Akin Belli A, Etgu F, Ozbas Gok S, Kara B, Dogan G
Pediatr Dermatol 2016 Jul;33(4):438-42. Epub 2016 Jun 13 doi: 10.1111/pde.12881. PMID: 27292443
Dermatologic manifestations of ataxia-telangiectasia syndrome.
Greenberger S, Berkun Y, Ben-Zeev B, Levi YB, Barziliai A, Nissenkorn A
J Am Acad Dermatol 2013 Jun;68(6):932-6. Epub 2013 Jan 27 doi: 10.1016/j.jaad.2012.12.950. PMID: 23360865
Premature hair whitening is an independent predictor of carotid intima-media thickness in young and middle-aged men.
Erdoğan T, Kocaman SA, Çetin M, Durakoğlugil ME, Uğurlu Y, Şahin İ, Çanga A
Intern Med 2013;52(1):29-36. Epub 2013 Jan 1 doi: 10.2169/internalmedicine.52.7842. PMID: 23291671
The degree of premature hair graying as an independent risk marker for coronary artery disease: a predictor of biological age rather than chronological age.
Kocaman SA, Çetin M, Durakoğlugil ME, Erdoğan T, Çanga A, Çiçek Y, Doğan S, Şahin I, Şatıroğlu O, Bostan M
Anadolu Kardiyol Derg 2012 Sep;12(6):457-63. Epub 2012 Jun 7 doi: 10.5152/akd.2012.150. PMID: 22677402

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