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Zinc, elevated plasma

MedGen UID:
349756
•Concept ID:
C1860228
•
Finding
Synonyms: ALBUMIN BINDING OF ZINC, ELEVATED; HYPERZINCEMIA, FAMILIAL DYSALBUMINEMIC
 
Monarch Initiative: MONDO:0008691
OMIM®: 194470

Clinical features

From HPO
Abnormality of metabolism/homeostasis
MedGen UID:
867398
•Concept ID:
C4021768
•
Finding
See: Feature record | Search on this feature

Professional guidelines

PubMed

Health Risk Assessment of Heavy Metals Due to Wheat, Cabbage, and Spinach Consumption at Cold-Arid High Altitude Region.
Giri A, Bharti VK, Kalia S, Acharya S, Kumar B, Chaurasia OP
Biol Trace Elem Res 2022 Sep;200(9):4186-4198. Epub 2021 Nov 8 doi: 10.1007/s12011-021-03006-4. PMID: 34750742
Zinc deficiency and its association with treatment-related toxicity in children with cancer.
Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB
Pediatr Blood Cancer 2021 Sep;68(9):e29104. Epub 2021 Jun 1 doi: 10.1002/pbc.29104. PMID: 34061438
Circulating essential metals and lung cancer: Risk assessment and potential molecular effects.
Bai Y, Wang G, Fu W, Lu Y, Wei W, Chen W, Wu X, Meng H, Feng Y, Liu Y, Li G, Wang S, Wang K, Dai J, Li H, Li M, Huang J, Li Y, Wei S, Yuan J, Yao P, Miao X, He M, Zhang X, Yang H, Wu T, Guo H
Environ Int 2019 Jun;127:685-693. Epub 2019 Apr 13 doi: 10.1016/j.envint.2019.04.021. PMID: 30991224

Recent clinical studies

Etiology

Growth and Nutritional Status of Phenylketonuric Children and Adolescents.
Ahmadzadeh M, Sohrab G, Alaei M, Eini-Zinab H, Mohammadpour-Ahranjani B, Rastgoo S, Namkhah Z
BMC Pediatr 2022 Nov 17;22(1):664. doi: 10.1186/s12887-022-03715-2. PMID: 36384480Free PMC Article
Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Castro ÁDS, Albuquerque LDS, Melo MLP, D'Almeida JAC, Braga RAM, Assis RC, Marreiro DDN, Matos WO, Maia CSC
Mult Scler Relat Disord 2022 Oct;66:104063. Epub 2022 Jul 18 doi: 10.1016/j.msard.2022.104063. PMID: 35872505
Epigenetic alterations of CXCL5 in Cr(VI)-induced carcinogenesis.
Ge X, He J, Wang L, Zhao L, Wang Y, Wu G, Liu W, Shu Y, Gong W, Ma XL, Wang Y, Jiang BH, Liu LZ
Sci Total Environ 2022 Sep 10;838(Pt 1):155713. Epub 2022 Jun 1 doi: 10.1016/j.scitotenv.2022.155713. PMID: 35660107Free PMC Article
Association of Zinc and Copper Status with Cardiovascular Diseases and their Assessment Methods: A Review Study.
Malekahmadi M, Firouzi S, Rezayi M, Ghazizadeh H, Ranjbar G, Ferns GA, Mobarhan MG
Mini Rev Med Chem 2020;20(19):2067-2078. doi: 10.2174/1389557520666200729160416. PMID: 32727323
Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Fernández-Cao JC, Warthon-Medina M, H Moran V, Arija V, Doepking C, Serra-Majem L, Lowe NM
Nutrients 2019 May 8;11(5) doi: 10.3390/nu11051027. PMID: 31071930Free PMC Article

Diagnosis

Relationship between zinc-related nutritional status and the progression of multiple sclerosis.
Castro ÁDS, Albuquerque LDS, Melo MLP, D'Almeida JAC, Braga RAM, Assis RC, Marreiro DDN, Matos WO, Maia CSC
Mult Scler Relat Disord 2022 Oct;66:104063. Epub 2022 Jul 18 doi: 10.1016/j.msard.2022.104063. PMID: 35872505
Zinc deficiency and its association with treatment-related toxicity in children with cancer.
Chung JH, Phalke N, Hastings C, Killilea DW, Feusner JH, Fung EB
Pediatr Blood Cancer 2021 Sep;68(9):e29104. Epub 2021 Jun 1 doi: 10.1002/pbc.29104. PMID: 34061438
Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus.
Samadi A, Isikhan SY, Tinkov AA, Lay I, Doşa MD, Skalny AV, Skalnaya MG, Chirumbolo S, Bjørklund G
Clin Nutr 2020 Jun;39(6):1849-1856. Epub 2019 Aug 6 doi: 10.1016/j.clnu.2019.07.026. PMID: 31427180
Allosteric modulation of zinc speciation by fatty acids.
Barnett JP, Blindauer CA, Kassaar O, Khazaipoul S, Martin EM, Sadler PJ, Stewart AJ
Biochim Biophys Acta 2013 Dec;1830(12):5456-64. Epub 2013 May 29 doi: 10.1016/j.bbagen.2013.05.028. PMID: 23726993
Zinc-α2-glycoprotein as a marker of fat catabolism in humans.
Cabassi A, Tedeschi S
Curr Opin Clin Nutr Metab Care 2013 May;16(3):267-71. doi: 10.1097/MCO.0b013e32835f816c. PMID: 23448999

Therapy

Pathogenesis-directed therapy of 2019 novel coronavirus disease.
Stratton CW, Tang YW, Lu H
J Med Virol 2021 Mar;93(3):1320-1342. Epub 2020 Nov 10 doi: 10.1002/jmv.26610. PMID: 33073355
Selenium, Zinc, and Manganese Status in Pregnant Women and Its Relation to Maternal and Child Complications.
Iqbal S, Ali I, Rust P, Kundi M, Ekmekcioglu C
Nutrients 2020 Mar 10;12(3) doi: 10.3390/nu12030725. PMID: 32164189Free PMC Article
Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Fernández-Cao JC, Warthon-Medina M, H Moran V, Arija V, Doepking C, Serra-Majem L, Lowe NM
Nutrients 2019 May 8;11(5) doi: 10.3390/nu11051027. PMID: 31071930Free PMC Article
Red meat intake in chronic kidney disease patients: Two sides of the coin.
Mafra D, Borges NA, Cardozo LFMF, Anjos JS, Black AP, Moraes C, Bergman P, Lindholm B, Stenvinkel P
Nutrition 2018 Feb;46:26-32. Epub 2017 Sep 19 doi: 10.1016/j.nut.2017.08.015. PMID: 29290351
Discerning the Mauve factor, Part 2.
McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A, Lauda PH, Bibus DM, Jurnak F, Lietha R, Hoffer A
Altern Ther Health Med 2008 May-Jun;14(3):56-62. PMID: 18517107

Prognosis

Metabolic linkages between zinc exposure and lung cancer risk: A nested case-control study.
Bai Y, Cao Q, Guan X, Meng H, Feng Y, Wang C, Fu M, Hong S, Zhou Y, Yuan F, Zhang X, He M, Guo H
Sci Total Environ 2022 Sep 1;837:155796. Epub 2022 May 11 doi: 10.1016/j.scitotenv.2022.155796. PMID: 35561928
The Interplay between Non-Esterified Fatty Acids and Plasma Zinc and Its Influence on Thrombotic Risk in Obesity and Type 2 Diabetes.
Hierons SJ, Marsh JS, Wu D, Blindauer CA, Stewart AJ
Int J Mol Sci 2021 Sep 20;22(18) doi: 10.3390/ijms221810140. PMID: 34576303Free PMC Article
Effect of zinc supplementation on hemogram parameters and circulating concentrations of homocysteine, vitamin B(12), and folate in zinc-deficient children and adolescents.
Sonmez Ozkarakaya I, Celik B, Karakukcu C, Altuner Torun Y
J Trace Elem Med Biol 2021 May;65:126724. Epub 2021 Jan 23 doi: 10.1016/j.jtemb.2021.126724. PMID: 33550037
Pathogenesis-directed therapy of 2019 novel coronavirus disease.
Stratton CW, Tang YW, Lu H
J Med Virol 2021 Mar;93(3):1320-1342. Epub 2020 Nov 10 doi: 10.1002/jmv.26610. PMID: 33073355
Relationships between hyperinsulinaemia, magnesium, vitamin D, thrombosis and COVID-19: rationale for clinical management.
Cooper ID, Crofts CAP, DiNicolantonio JJ, Malhotra A, Elliott B, Kyriakidou Y, Brookler KH
Open Heart 2020 Sep;7(2) doi: 10.1136/openhrt-2020-001356. PMID: 32938758Free PMC Article

Clinical prediction guides

Alterations in metal homeostasis occur prior to canonical markers in Huntington disease.
Pfalzer AC, Yan Y, Kang H, Totten M, Silverman J, Bowman AB, Erikson K, Claassen DO
Sci Rep 2022 Jun 20;12(1):10373. doi: 10.1038/s41598-022-14169-y. PMID: 35725749Free PMC Article
Plasma metal concentrations and their interactions with genetic susceptibility on homocysteine levels.
Long P, Wang H, Zhang Z, Li W, Zhang Y, He S, Yu K, Jiang H, Liu X, Guo H, He M, Zhang X, Wu T, Yuan Y
Ecotoxicol Environ Saf 2022 Aug;241:113705. Epub 2022 Jun 7 doi: 10.1016/j.ecoenv.2022.113705. PMID: 35687997
The Interplay between Non-Esterified Fatty Acids and Plasma Zinc and Its Influence on Thrombotic Risk in Obesity and Type 2 Diabetes.
Hierons SJ, Marsh JS, Wu D, Blindauer CA, Stewart AJ
Int J Mol Sci 2021 Sep 20;22(18) doi: 10.3390/ijms221810140. PMID: 34576303Free PMC Article
Elevated serum levels of S100A1 and zinc α2-glycoprotein in patients with heart failure.
Soltani L, Kheirouri S, Enamzadeh E
Nutr Metab Cardiovasc Dis 2021 Jan 4;31(1):162-168. Epub 2020 Jul 29 doi: 10.1016/j.numecd.2020.07.029. PMID: 33257194
Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Fernández-Cao JC, Warthon-Medina M, H Moran V, Arija V, Doepking C, Serra-Majem L, Lowe NM
Nutrients 2019 May 8;11(5) doi: 10.3390/nu11051027. PMID: 31071930Free PMC Article

Recent systematic reviews

Systematic Review and Meta-Analysis of Oxidative Stress and Antioxidant Markers in Oral Lichen Planus.
Wang J, Yang J, Wang C, Zhao Z, Fan Y
Oxid Med Cell Longev 2021;2021:9914652. Epub 2021 Sep 27 doi: 10.1155/2021/9914652. PMID: 34616506Free PMC Article
The association of the adipokine zinc-alpha2-glycoprotein with non-alcoholic fatty liver disease and related risk factors: A comprehensive systematic review.
Namkhah Z, Naeini F, Ostadrahimi A, Tutunchi H, Hosseinzadeh-Attar MJ
Int J Clin Pract 2021 Jul;75(7):e13985. Epub 2021 Jan 21 doi: 10.1111/ijcp.13985. PMID: 33404166
A meta-analysis of zinc levels in breast cancer.
Jouybari L, Kiani F, Akbari A, Sanagoo A, Sayehmiri F, Aaseth J, Chartrand MS, Sayehmiri K, Chirumbolo S, Bjørklund G
J Trace Elem Med Biol 2019 Dec;56:90-99. Epub 2019 Jun 20 doi: 10.1016/j.jtemb.2019.06.017. PMID: 31442959
Zinc Intake and Status and Risk of Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.
Fernández-Cao JC, Warthon-Medina M, H Moran V, Arija V, Doepking C, Serra-Majem L, Lowe NM
Nutrients 2019 May 8;11(5) doi: 10.3390/nu11051027. PMID: 31071930Free PMC Article

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