U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bone pain, periodic

MedGen UID:
350612
•Concept ID:
C1862176
•
Finding
Synonym: BONE PAIN, PERIODIC
 
Monarch Initiative: MONDO:0007206
OMIM®: 112270

Clinical features

From HPO
Bone pain
MedGen UID:
57489
•Concept ID:
C0151825
•
Sign or Symptom
An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
See: Feature record | Search on this feature

Professional guidelines

PubMed

Diagnosis and Management of Lumbar Spinal Stenosis: A Review.
Katz JN, Zimmerman ZE, Mass H, Makhni MC
JAMA 2022 May 3;327(17):1688-1699. doi: 10.1001/jama.2022.5921. PMID: 35503342
Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline.
Ralston SH, Corral-Gudino L, Cooper C, Francis RM, Fraser WD, Gennari L, Guañabens N, Javaid MK, Layfield R, O'Neill TW, Russell RGG, Stone MD, Simpson K, Wilkinson D, Wills R, Zillikens MC, Tuck SP
J Bone Miner Res 2019 Apr;34(4):579-604. Epub 2019 Feb 25 doi: 10.1002/jbmr.3657. PMID: 30803025Free PMC Article
Osteoarthritis: diagnosis and treatment.
Sinusas K
Am Fam Physician 2012 Jan 1;85(1):49-56. PMID: 22230308

Recent clinical studies

Etiology

Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review.
Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S
Int J Implant Dent 2021 Dec 19;7(1):117. doi: 10.1186/s40729-021-00393-0. PMID: 34923613Free PMC Article
Two manual therapy techniques for management of lumbar radiculopathy: a randomized clinical trial.
Danazumi MS, Bello B, Yakasai AM, Kaka B
J Osteopath Med 2021 Feb 26;121(4):391-400. doi: 10.1515/jom-2020-0261. PMID: 33705612
Gaucher Disease in Bone: From Pathophysiology to Practice.
Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, Kindmark A, Mistry P, Poll L, Weinreb N, Deegan P
J Bone Miner Res 2019 Jun;34(6):996-1013. Epub 2019 Jun 24 doi: 10.1002/jbmr.3734. PMID: 31233632Free PMC Article
Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cervicogenic headache: a multi-center randomized clinical trial.
Dunning JR, Butts R, Mourad F, Young I, Fernandez-de-Las Peñas C, Hagins M, Stanislawski T, Donley J, Buck D, Hooks TR, Cleland JA
BMC Musculoskelet Disord 2016 Feb 6;17:64. doi: 10.1186/s12891-016-0912-3. PMID: 26852024Free PMC Article

Diagnosis

Stress fractures.
da Rocha Lemos Costa TM, Borba VZC, Correa RGP, Moreira CA
Arch Endocrinol Metab 2022 Nov 11;66(5):765-773. doi: 10.20945/2359-3997000000562. PMID: 36382766Free PMC Article
Diagnosis and Management of Lumbar Spinal Stenosis: A Review.
Katz JN, Zimmerman ZE, Mass H, Makhni MC
JAMA 2022 May 3;327(17):1688-1699. doi: 10.1001/jama.2022.5921. PMID: 35503342
Two manual therapy techniques for management of lumbar radiculopathy: a randomized clinical trial.
Danazumi MS, Bello B, Yakasai AM, Kaka B
J Osteopath Med 2021 Feb 26;121(4):391-400. doi: 10.1515/jom-2020-0261. PMID: 33705612
Athletic Pubalgia (Sports Hernia): Presentation and Treatment.
Drager J, Rasio J, Newhouse A
Arthroscopy 2020 Dec;36(12):2952-2953. doi: 10.1016/j.arthro.2020.09.022. PMID: 33276883
Gaucher Disease in Bone: From Pathophysiology to Practice.
Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, Kindmark A, Mistry P, Poll L, Weinreb N, Deegan P
J Bone Miner Res 2019 Jun;34(6):996-1013. Epub 2019 Jun 24 doi: 10.1002/jbmr.3734. PMID: 31233632Free PMC Article

Therapy

Diagnosis and Management of Lumbar Spinal Stenosis: A Review.
Katz JN, Zimmerman ZE, Mass H, Makhni MC
JAMA 2022 May 3;327(17):1688-1699. doi: 10.1001/jama.2022.5921. PMID: 35503342
Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review.
Al-Maawi S, Becker K, Schwarz F, Sader R, Ghanaati S
Int J Implant Dent 2021 Dec 19;7(1):117. doi: 10.1186/s40729-021-00393-0. PMID: 34923613Free PMC Article
Two manual therapy techniques for management of lumbar radiculopathy: a randomized clinical trial.
Danazumi MS, Bello B, Yakasai AM, Kaka B
J Osteopath Med 2021 Feb 26;121(4):391-400. doi: 10.1515/jom-2020-0261. PMID: 33705612
Isometric exercise and pain in patellar tendinopathy: A randomized crossover trial.
Holden S, Lyng K, Graven-Nielsen T, Riel H, Olesen JL, Larsen LH, Rathleff MS
J Sci Med Sport 2020 Mar;23(3):208-214. Epub 2019 Oct 10 doi: 10.1016/j.jsams.2019.09.015. PMID: 31735531
Effects of Adding a Neurodynamic Mobilization to Motor Control Training in Patients With Lumbar Radiculopathy Due to Disc Herniation: A Randomized Clinical Trial.
Plaza-Manzano G, Cancela-Cilleruelo I, Fernández-de-Las-Peñas C, Cleland JA, Arias-Buría JL, Thoomes-de-Graaf M, Ortega-Santiago R
Am J Phys Med Rehabil 2020 Feb;99(2):124-132. doi: 10.1097/PHM.0000000000001295. PMID: 31464753

Prognosis

Gaucher Disease in Bone: From Pathophysiology to Practice.
Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, Kindmark A, Mistry P, Poll L, Weinreb N, Deegan P
J Bone Miner Res 2019 Jun;34(6):996-1013. Epub 2019 Jun 24 doi: 10.1002/jbmr.3734. PMID: 31233632Free PMC Article
Hallmarks of Bone Metastasis.
Johnson RW, Suva LJ
Calcif Tissue Int 2018 Feb;102(2):141-151. Epub 2017 Nov 14 doi: 10.1007/s00223-017-0362-4. PMID: 29138883Free PMC Article
Surgical treatment for periacetabular metastatic lesions.
Charles T, Ameye L, Gebhart M
Eur J Surg Oncol 2017 Sep;43(9):1727-1732. Epub 2017 Apr 8 doi: 10.1016/j.ejso.2017.03.018. PMID: 28483275
Restriction in lateral bending range of motion, lumbar lordosis, and hamstring flexibility predicts the development of low back pain: a systematic review of prospective cohort studies.
Sadler SG, Spink MJ, Ho A, De Jonge XJ, Chuter VH
BMC Musculoskelet Disord 2017 May 5;18(1):179. doi: 10.1186/s12891-017-1534-0. PMID: 28476110Free PMC Article
Upper cervical and upper thoracic manipulation versus mobilization and exercise in patients with cervicogenic headache: a multi-center randomized clinical trial.
Dunning JR, Butts R, Mourad F, Young I, Fernandez-de-Las Peñas C, Hagins M, Stanislawski T, Donley J, Buck D, Hooks TR, Cleland JA
BMC Musculoskelet Disord 2016 Feb 6;17:64. doi: 10.1186/s12891-016-0912-3. PMID: 26852024Free PMC Article

Clinical prediction guides

Effect of Spinal Cord Burst Stimulation vs Placebo Stimulation on Disability in Patients With Chronic Radicular Pain After Lumbar Spine Surgery: A Randomized Clinical Trial.
Hara S, Andresen H, Solheim O, Carlsen SM, Sundstrøm T, Lønne G, Lønne VV, Taraldsen K, Tronvik EA, Øie LR, Gulati AM, Sagberg LM, Jakola AS, Solberg TK, Nygaard ØP, Salvesen ØO, Gulati S
JAMA 2022 Oct 18;328(15):1506-1514. doi: 10.1001/jama.2022.18231. PMID: 36255427Free PMC Article
Diagnosis and Management of Lumbar Spinal Stenosis: A Review.
Katz JN, Zimmerman ZE, Mass H, Makhni MC
JAMA 2022 May 3;327(17):1688-1699. doi: 10.1001/jama.2022.5921. PMID: 35503342
Gaucher Disease in Bone: From Pathophysiology to Practice.
Hughes D, Mikosch P, Belmatoug N, Carubbi F, Cox T, Goker-Alpan O, Kindmark A, Mistry P, Poll L, Weinreb N, Deegan P
J Bone Miner Res 2019 Jun;34(6):996-1013. Epub 2019 Jun 24 doi: 10.1002/jbmr.3734. PMID: 31233632Free PMC Article
Upper thoracic spine mobilization and mobility exercise versus upper cervical spine mobilization and stabilization exercise in individuals with forward head posture: a randomized clinical trial.
Cho J, Lee E, Lee S
BMC Musculoskelet Disord 2017 Dec 12;18(1):525. doi: 10.1186/s12891-017-1889-2. PMID: 29233164Free PMC Article
Restriction in lateral bending range of motion, lumbar lordosis, and hamstring flexibility predicts the development of low back pain: a systematic review of prospective cohort studies.
Sadler SG, Spink MJ, Ho A, De Jonge XJ, Chuter VH
BMC Musculoskelet Disord 2017 May 5;18(1):179. doi: 10.1186/s12891-017-1534-0. PMID: 28476110Free PMC Article

Recent systematic reviews

Incidence of Spontaneous Resorption of Lumbar Disc Herniation: A Meta-Analysis.
Zhong M, Liu JT, Jiang H, Mo W, Yu PF, Li XC, Xue RR
Pain Physician 2017 Jan-Feb;20(1):E45-E52. PMID: 28072796
Impacted wisdom teeth.
Dodson TB, Susarla SM
BMJ Clin Evid 2014 Aug 29;2014 PMID: 25170946Free PMC Article
Rehabilitation after lumbar disc surgery.
Oosterhuis T, Costa LO, Maher CG, de Vet HC, van Tulder MW, Ostelo RW
Cochrane Database Syst Rev 2014 Mar 14;2014(3):CD003007. doi: 10.1002/14651858.CD003007.pub3. PMID: 24627325Free PMC Article
Rehabilitation for ankle fractures in adults.
Lin CW, Donkers NA, Refshauge KM, Beckenkamp PR, Khera K, Moseley AM
Cochrane Database Syst Rev 2012 Nov 14;11:CD005595. doi: 10.1002/14651858.CD005595.pub3. PMID: 23152232
Interventions for preventing falls in older people living in the community.
Gillespie LD, Robertson MC, Gillespie WJ, Sherrington C, Gates S, Clemson LM, Lamb SE
Cochrane Database Syst Rev 2012 Sep 12;2012(9):CD007146. doi: 10.1002/14651858.CD007146.pub3. PMID: 22972103Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...