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B-Symptoms

MedGen UID:
353402
•Concept ID:
C1706867
•
Sign or Symptom

Definition

Features commonly associated with lymphoma, including fever above 38C, drenching night sweats, and weight loss of more than 10% of body mass in the previous 6 months. B symptoms are signs of a poor prognosis in patients with lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-Symptoms

Professional guidelines

PubMed

Diagnosis and Treatment of Chronic Lymphocytic Leukemia: A Review.
Shadman M
JAMA 2023 Mar 21;329(11):918-932. doi: 10.1001/jama.2023.1946. PMID: 36943212
EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2022 update on diagnosis, risk-stratification, and management.
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Comparative Effectiveness of Antibiotic Treatment Duration in Children With Pyelonephritis.
Fox MT, Amoah J, Hsu AJ, Herzke CA, Gerber JS, Tamma PD
JAMA Netw Open 2020 May 1;3(5):e203951. doi: 10.1001/jamanetworkopen.2020.3951. PMID: 32364593Free PMC Article

Recent clinical studies

Etiology

Pediatric classical Hodgkin lymphoma.
Lo AC, Dieckmann K, Pelz T, Gallop-Evans E, Engenhart-Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, Hodgson D
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28562. doi: 10.1002/pbc.28562. PMID: 33818890
Current treatment and future prospects for peripheral T-cell lymphoma.
Eyre TA, Collins GP
Drugs Today (Barc) 2013 Oct;49(10):631-46. doi: 10.1358/dot.2013.49.10.2025391. PMID: 24191256
Predicting transformation in follicular lymphoma.
de Jong D, de Boer JP
Leuk Lymphoma 2009 Sep;50(9):1406-11. doi: 10.1080/10428190903093815. PMID: 19606378
Primary testicular lymphoma.
Vitolo U, Ferreri AJ, Zucca E
Crit Rev Oncol Hematol 2008 Feb;65(2):183-9. Epub 2007 Oct 24 doi: 10.1016/j.critrevonc.2007.08.005. PMID: 17962036
Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole.
Pereira Rde S
J Pineal Res 2006 Oct;41(3):195-200. doi: 10.1111/j.1600-079X.2006.00359.x. PMID: 16948779

Diagnosis

B Symptoms and Gastric Pain.
Hudowenz O, Müller-Ladner U, Klemm P
Dtsch Arztebl Int 2020 Jun 12;117(24):420. doi: 10.3238/arztebl.2020.0420. PMID: 32865493Free PMC Article
The Treatment of Chronic Lymphatic Leukemia.
Tresckow JV, Eichhorst B, Bahlo J, Hallek M
Dtsch Arztebl Int 2019 Jan 25;116(4):41-46. doi: 10.3238/arztebl.2019.0041. PMID: 30855005Free PMC Article
Primary hepatic lymphoma.
Padhan RK, Das P, Shalimar
Trop Gastroenterol 2015 Jan-Mar;36(1):14-20. doi: 10.7869/tg.239. PMID: 26591949
Intravascular large B-cell lymphoma.
Orwat DE, Batalis NI
Arch Pathol Lab Med 2012 Mar;136(3):333-8. doi: 10.5858/arpa.2010-0747-RS. PMID: 22372911
Lymphoplasmacytic lymphoma-Waldenstrom's macroglobulinemia.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Therapy

Nivolumab and brentuximab vedotin with or without bendamustine for R/R Hodgkin lymphoma in children, adolescents, and young adults.
Harker-Murray P, Mauz-Körholz C, Leblanc T, Mascarin M, Michel G, Cooper S, Beishuizen A, Leger KJ, Amoroso L, Buffardi S, Rigaud C, Hoppe BS, Lisano J, Francis S, Sacchi M, Cole PD, Drachtman RA, Kelly KM, Daw S
Blood 2023 Apr 27;141(17):2075-2084. doi: 10.1182/blood.2022017118. PMID: 36564047Free PMC Article
Pediatric classical Hodgkin lymphoma.
Lo AC, Dieckmann K, Pelz T, Gallop-Evans E, Engenhart-Cabillic R, Vordermark D, Kelly KM, Schwartz CL, Constine LS, Roberts K, Hodgson D
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28562. doi: 10.1002/pbc.28562. PMID: 33818890
The treatment of older Hodgkin lymphoma patients.
Böll B, Görgen H
Br J Haematol 2019 Jan;184(1):82-92. Epub 2018 Nov 8 doi: 10.1111/bjh.15652. PMID: 30407626
Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole.
Pereira Rde S
J Pineal Res 2006 Oct;41(3):195-200. doi: 10.1111/j.1600-079X.2006.00359.x. PMID: 16948779
Gastrointestinal lymphoma.
Thomas CR Jr, Share R
Med Pediatr Oncol 1991;19(1):48-60. doi: 10.1002/mpo.2950190109. PMID: 1990257

Prognosis

Neutrophil-to-Lymphocyte Ratio and Ferritin as Measurable Tools for Disease Burden and B Symptoms in Pediatric Patients With Hodgkin Lymphoma.
Jan S, Mustafa O, Elgaml A, Ahmad N, Abbas A, Althubaiti S
J Pediatr Hematol Oncol 2022 Mar 1;44(2):e567-e571. doi: 10.1097/MPH.0000000000002346. PMID: 34654761
Epidemiology of Non-Hodgkin's Lymphoma in India.
Nair R, Arora N, Mallath MK
Oncology 2016;91 Suppl 1:18-25. Epub 2016 Jul 28 doi: 10.1159/000447577. PMID: 27462703
Anaplastic large cell lymphoma, ALK-negative.
Ferreri AJ, Govi S, Pileri SA, Savage KJ
Crit Rev Oncol Hematol 2013 Feb;85(2):206-15. Epub 2012 Jul 11 doi: 10.1016/j.critrevonc.2012.06.004. PMID: 22789917
Peripheral T-cell lymphoma--not otherwise specified.
Savage KJ, Ferreri AJ, Zinzani PL, Pileri SA
Crit Rev Oncol Hematol 2011 Sep;79(3):321-9. Epub 2010 Aug 10 doi: 10.1016/j.critrevonc.2010.07.007. PMID: 20702104
Predicting transformation in follicular lymphoma.
de Jong D, de Boer JP
Leuk Lymphoma 2009 Sep;50(9):1406-11. doi: 10.1080/10428190903093815. PMID: 19606378

Clinical prediction guides

Clinical characteristics and treatment of NK/T-cell lymphoma-associated HLH.
Meng G, Wang J, Cui T, Wang Z
Ann Hematol 2022 Oct;101(10):2289-2296. Epub 2022 Aug 24 doi: 10.1007/s00277-022-04953-1. PMID: 35999388
EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2022 update on diagnosis, risk-stratification, and management.
Malpica L, Marques-Piubelli ML, Beltran BE, Chavez JC, Miranda RN, Castillo JJ
Am J Hematol 2022 Jul;97(7):951-965. Epub 2022 May 3 doi: 10.1002/ajh.26579. PMID: 35472248
Smoldering mantle cell lymphoma.
Ye H, Desai A, Zeng D, Nomie K, Romaguera J, Ahmed M, Wang ML
J Exp Clin Cancer Res 2017 Dec 15;36(1):185. doi: 10.1186/s13046-017-0652-8. PMID: 29246179Free PMC Article
Primary adrenal lymphoma: a systematic review.
Rashidi A, Fisher SI
Ann Hematol 2013 Dec;92(12):1583-93. Epub 2013 Jun 15 doi: 10.1007/s00277-013-1812-3. PMID: 23771429
Lymphoplasmacytic lymphoma-Waldenstrom's macroglobulinemia.
Vitolo U, Ferreri AJ, Montoto S
Crit Rev Oncol Hematol 2008 Aug;67(2):172-85. Epub 2008 May 21 doi: 10.1016/j.critrevonc.2008.03.008. PMID: 18499469

Recent systematic reviews

Current evidence on diagnosis and treatment of parotid gland lymphomas: a systematic review.
Di Santo D, Bramati C, Festa BM, Pace GM, Comini LV, Luparello P, Cascardi E, Galizia D, Galli A, De Virgilio A, Giordano L, Bondi S
Eur Arch Otorhinolaryngol 2023 Dec;280(12):5219-5227. Epub 2023 Aug 28 doi: 10.1007/s00405-023-08206-3. PMID: 37638999
Inferior survival and frequent hepatic dysfunction in non-Hodgkin's lymphoma patients with HBV infection: a systematic review and meta-analysis.
Zhang MY, Gao F, Zhao YW, Ni BW, Huang HH, Hou J
Hematology 2022 Dec;27(1):70-79. doi: 10.1080/16078454.2021.2011546. PMID: 34957924
Primary Gastrointestinal Non-Hodgkin's Lymphoma of the Small and Large Intestines: a Systematic Review.
Lightner AL, Shannon E, Gibbons MM, Russell MM
J Gastrointest Surg 2016 Apr;20(4):827-39. Epub 2015 Dec 16 doi: 10.1007/s11605-015-3052-4. PMID: 26676930
Clinical manifestations in children with tonsillar lymphoma: A systematic review.
Guimarães AC, de Carvalho GM, Bento LR, Correa C, Gusmão RJ
Crit Rev Oncol Hematol 2014 May;90(2):146-51. Epub 2013 Dec 14 doi: 10.1016/j.critrevonc.2013.12.005. PMID: 24387945
Primary adrenal lymphoma: a systematic review.
Rashidi A, Fisher SI
Ann Hematol 2013 Dec;92(12):1583-93. Epub 2013 Jun 15 doi: 10.1007/s00277-013-1812-3. PMID: 23771429

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