U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bone Leiomyoma

MedGen UID:
353430
•Concept ID:
C1706980
•
Neoplastic Process

Definition

A rare leiomyoma affecting the bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBone Leiomyoma

Professional guidelines

PubMed

New treatment options for nonsurgical management of uterine fibroids.
Lee S, Stewart EA
Curr Opin Obstet Gynecol 2023 Aug 1;35(4):288-293. Epub 2023 May 3 doi: 10.1097/GCO.0000000000000880. PMID: 37144584Free PMC Article
Oral Gonadotropin-Releasing Hormone Antagonists for the Treatment of Uterine Leiomyomas.
Neblett MF 2nd, Stewart EA
Obstet Gynecol 2023 May 1;141(5):901-910. Epub 2023 Apr 5 doi: 10.1097/AOG.0000000000005145. PMID: 37103532
EMAS position statement: management of uterine fibroids.
Pérez-López FR, Ornat L, Ceausu I, Depypere H, Erel CT, Lambrinoudaki I, Schenck-Gustafsson K, Simoncini T, Tremollieres F, Rees M; EMAS
Maturitas 2014 Sep;79(1):106-16. Epub 2014 Jun 9 doi: 10.1016/j.maturitas.2014.06.002. PMID: 24975954

Recent clinical studies

Etiology

Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials.
Donnez J, Taylor HS, Stewart EA, Bradley L, Marsh E, Archer D, Al-Hendy A, Petraglia F, Watts N, Gotteland JP, Bestel E, Terrill P, Loumaye E, Humberstone A, Garner E
Lancet 2022 Sep 17;400(10356):896-907. doi: 10.1016/S0140-6736(22)01475-1. PMID: 36116480
Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, Critchley HOD, Li Y, McKain L, Arjona Ferreira JC, Langenberg AGM, Wagman RB, Stewart EA
N Engl J Med 2021 Feb 18;384(7):630-642. doi: 10.1056/NEJMoa2008283. PMID: 33596357Free PMC Article
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Vitamin D and female fertility.
Lerchbaum E, Rabe T
Curr Opin Obstet Gynecol 2014 Jun;26(3):145-50. doi: 10.1097/GCO.0000000000000065. PMID: 24717915

Diagnosis

Magnetic Resonance-Guided High-Intensity Focused Ultrasound (MR-HIFU): Technical Background and Overview of Current Clinical Applications (Part 1).
Siedek F, Yeo SY, Heijman E, Grinstein O, Bratke G, Heneweer C, Puesken M, Persigehl T, Maintz D, Grüll H
Rofo 2019 Jun;191(6):522-530. Epub 2019 Jan 10 doi: 10.1055/a-0817-5645. PMID: 30630200
Indications for morcellation in gynecologic surgery.
Parker WH
Curr Opin Obstet Gynecol 2018 Feb;30(1):75-80. doi: 10.1097/GCO.0000000000000427. PMID: 29251677
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Soft tissue tumors with muscle differentiation.
Davies CE, Davies AM, Kindblom LG, James SL
Semin Musculoskelet Radiol 2010 Jun;14(2):245-56. Epub 2010 May 18 doi: 10.1055/s-0030-1253165. PMID: 20486032
Frontal intradiploic angioleiomyoma.
Vijayasaradhi M, Uppin SG, Sreedhar V, Sundaram C, Panigrahi MK
J Neurosurg Pediatr 2008 Oct;2(4):266-8. doi: 10.3171/PED.2008.2.10.266. PMID: 18831661

Therapy

Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Relugolix/Estradiol/Norethisterone (Norethindrone) Acetate: A Review in Symptomatic Uterine Fibroids.
Syed YY
Drugs 2022 Oct;82(15):1549-1556. Epub 2022 Nov 4 doi: 10.1007/s40265-022-01790-4. PMID: 36331779Free PMC Article
Linzagolix with and without hormonal add-back therapy for the treatment of symptomatic uterine fibroids: two randomised, placebo-controlled, phase 3 trials.
Donnez J, Taylor HS, Stewart EA, Bradley L, Marsh E, Archer D, Al-Hendy A, Petraglia F, Watts N, Gotteland JP, Bestel E, Terrill P, Loumaye E, Humberstone A, Garner E
Lancet 2022 Sep 17;400(10356):896-907. doi: 10.1016/S0140-6736(22)01475-1. PMID: 36116480
Treatment of Uterine Fibroid Symptoms with Relugolix Combination Therapy.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, Critchley HOD, Li Y, McKain L, Arjona Ferreira JC, Langenberg AGM, Wagman RB, Stewart EA
N Engl J Med 2021 Feb 18;384(7):630-642. doi: 10.1056/NEJMoa2008283. PMID: 33596357Free PMC Article
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article

Prognosis

Clinical Utility of Diffusion-Weighted Imaging in Gynecological Imaging: Revisited.
Fujii S, Gonda T, Yunaga H
Invest Radiol 2024 Jan 1;59(1):78-91. Epub 2023 Jul 27 doi: 10.1097/RLI.0000000000001004. PMID: 37493356
Benign Metastasizing Leiomyoma: Is "Wait and Watch" Strategy Feasible?
Liu Y, Li D, Li X, Wang J, Wang J
Reprod Sci 2023 Dec;30(12):3568-3577. Epub 2023 Aug 2 doi: 10.1007/s43032-023-01314-9. PMID: 37531066
A Deep Learning-Based System Trained for Gastrointestinal Stromal Tumor Screening Can Identify Multiple Types of Soft Tissue Tumors.
Meng Z, Wang G, Su F, Liu Y, Wang Y, Yang J, Luo J, Cao F, Zhen P, Huang B, Yin Y, Zhao Z, Guo L
Am J Pathol 2023 Jul;193(7):899-912. Epub 2023 Apr 15 doi: 10.1016/j.ajpath.2023.03.012. PMID: 37068638
Indications for morcellation in gynecologic surgery.
Parker WH
Curr Opin Obstet Gynecol 2018 Feb;30(1):75-80. doi: 10.1097/GCO.0000000000000427. PMID: 29251677
Fracture risk and bone density of peri- and early postmenopausal women with uterine leiomyomas.
Randell KM, Honkanen RJ, Tuppurainen MT, Kröger H, Jurvelin JS, Saarikoski S
Maturitas 2006 Feb 20;53(3):333-42. Epub 2005 Jul 12 doi: 10.1016/j.maturitas.2005.06.002. PMID: 16019169

Clinical prediction guides

Clinical Utility of Diffusion-Weighted Imaging in Gynecological Imaging: Revisited.
Fujii S, Gonda T, Yunaga H
Invest Radiol 2024 Jan 1;59(1):78-91. Epub 2023 Jul 27 doi: 10.1097/RLI.0000000000001004. PMID: 37493356
Relugolix combination therapy in European women with symptomatic uterine fibroids: a subgroup analysis from the randomized phase 3 LIBERTY pivotal trials.
Venturella R, Rechberger T, Zatik J, Wagman RB, Zhu E, Rakov VG, Petraglia F
Gynecol Endocrinol 2023 Aug 17;39(1):2249107. doi: 10.1080/09513590.2023.2249107. PMID: 37634528
Long-term Relugolix Combination Therapy for Symptomatic Uterine Leiomyomas.
Al-Hendy A, Lukes AS, Poindexter AN 3rd, Venturella R, Villarroel C, McKain L, Li Y, Wagman RB, Stewart EA
Obstet Gynecol 2022 Dec 1;140(6):920-930. Epub 2022 Nov 2 doi: 10.1097/AOG.0000000000004988. PMID: 36357960Free PMC Article
Add-back therapy with GnRH analogues for uterine fibroids.
Moroni RM, Martins WP, Ferriani RA, Vieira CS, Nastri CO, Candido Dos Reis FJ, Brito LG
Cochrane Database Syst Rev 2015 Mar 20;2015(3):CD010854. doi: 10.1002/14651858.CD010854.pub2. PMID: 25793972Free PMC Article
Vitamin D and female fertility.
Lerchbaum E, Rabe T
Curr Opin Obstet Gynecol 2014 Jun;26(3):145-50. doi: 10.1097/GCO.0000000000000065. PMID: 24717915

Recent systematic reviews

Endometrial Angiogenesis of Abnormal Uterine Bleeding and Infertility in Patients with Uterine Fibroids-A Systematic Review.
Don EE, Middelkoop MA, Hehenkamp WJK, Mijatovic V, Griffioen AW, Huirne JAF
Int J Mol Sci 2023 Apr 10;24(8) doi: 10.3390/ijms24087011. PMID: 37108180Free PMC Article
Elagolix treatment in women with heavy menstrual bleeding associated with uterine fibroid: a systematic review and meta-analysis.
Muhammad J, Yusof Y, Ahmad I, Norhayati MN
BMC Womens Health 2022 Jan 15;22(1):14. doi: 10.1186/s12905-022-01596-2. PMID: 35033041Free PMC Article
Skull Base Leiomyomas and Angioleiomyomas: A Systematic Literature Review and an Uncommon Case Report.
Rincon-Torroella J, Snyder MH, Galaiya DJ, Morris M, Weingart JD, Stewart CM
World Neurosurg 2021 Oct;154:154-166.e1. Epub 2021 Jun 26 doi: 10.1016/j.wneu.2021.06.096. PMID: 34182177Free PMC Article
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Add-back therapy with GnRH analogues for uterine fibroids.
Moroni RM, Martins WP, Ferriani RA, Vieira CS, Nastri CO, Candido Dos Reis FJ, Brito LG
Cochrane Database Syst Rev 2015 Mar 20;2015(3):CD010854. doi: 10.1002/14651858.CD010854.pub2. PMID: 25793972Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...