U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lung Fetal Adenocarcinoma

MedGen UID:
353690
•Concept ID:
C1708045
•
Neoplastic Process
Synonyms: Fetal Adenocarcinoma; Fetal adenocarcinoma of lung; Pulmonary Adenocarcinoma of Fetal Type; Pulmonary Endodermal Tumor Resembling Fetal Lung; Well-Differentiated Fetal Lung Adenocarcinoma
SNOMED CT: Fetal adenocarcinoma of lung (1260087003)

Definition

A rare morphologic variant of lung adenocarcinoma characterized by the presence of glandular structures containing glycogen-rich cells forming tubules that resemble fetal lung tubules. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLung Fetal Adenocarcinoma

Professional guidelines

PubMed

Gestational Trophoblastic Disease with Coexisting Progressing Pregnancy: Personalised Treatment Modalities.
Ulrikh E, Dikareva E, Govorov I, Komlichenko E, Pervunina T, Li O, Zhamborova O, Dzharbaeva A, Deynega V, Artemenko V, Urmancheeva A
Int J Clin Pract 2023;2023:5502317. Epub 2023 Oct 26 doi: 10.1155/2023/5502317. PMID: 37927849Free PMC Article
FDA Approval Summary: Pralsetinib for the Treatment of Lung and Thyroid Cancers With RET Gene Mutations or Fusions.
Kim J, Bradford D, Larkins E, Pai-Scherf LH, Chatterjee S, Mishra-Kalyani PS, Wearne E, Helms WS, Ayyoub A, Bi Y, Sun J, Charlab R, Liu J, Zhao H, Liang D, Ghosh S, Philip R, Pazdur R, Theoret MR, Beaver JA, Singh H
Clin Cancer Res 2021 Oct 15;27(20):5452-5456. Epub 2021 May 27 doi: 10.1158/1078-0432.CCR-21-0967. PMID: 34045295
Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology.
Gai W, Zhou Z, Agbor-Enoh S, Fan X, Lian S, Jiang P, Cheng SH, Wong J, Chan SL, Jang MK, Yang Y, Liang RH, Chan WK, Ma ES, Leung TY, Chiu RW, Valantine H, Chan KA, Lo YD
Elife 2021 Mar 23;10 doi: 10.7554/eLife.64356. PMID: 33752803Free PMC Article

Recent clinical studies

Etiology

Clinical and Pathological Characteristics and Prognosis of Lung Adenocarcinoma With High-Grade Fetal Features: A Retrospective Analysis.
Gu Y, Zhang S, Liang X, Zhao H, Li X, Lu J
Int J Surg Pathol 2024 Jun;32(4):667-678. Epub 2023 Jul 24 doi: 10.1177/10668969231188890. PMID: 37488988
The prognostic value of histopathology in invasive lung adenocarcinoma: a comparative review of the main proposed grading systems.
Lucà S, Zannini G, Morgillo F, Della Corte CM, Fiorelli A, Zito Marino F, Campione S, Vicidomini G, Guggino G, Ronchi A, Accardo M, Franco R
Expert Rev Anticancer Ther 2023 Mar;23(3):265-277. Epub 2023 Feb 20 doi: 10.1080/14737140.2023.2179990. PMID: 36772823
Morphologic, Immunohistochemical, and Genetic Differences Between High-grade and Low-grade Fetal Adenocarcinomas of the Lung.
Li Y, Xi SY, Yong JJ, Wu XY, Yang XH, Wang F
Am J Surg Pathol 2021 Nov 1;45(11):1464-1475. doi: 10.1097/PAS.0000000000001744. PMID: 34138800Free PMC Article
Clinicopathologic features and genomic analysis of pulmonary blastomatoid carcinosarcoma.
Zhao J, Xiang C, Zhao R, Guo P, Zheng J, Han-Zhang H, Yu K, Zhang J, Han Y
BMC Cancer 2020 Mar 24;20(1):248. doi: 10.1186/s12885-020-06748-x. PMID: 32209061Free PMC Article
Novel gene mutations in well-differentiated fetal adenocarcinoma of the lung in the next generation sequencing era.
Fu Y, Wu Q, Su F, Tang Y, Lin Y, Wang W, Jiang L
Lung Cancer 2018 Oct;124:1-5. Epub 2018 Jul 23 doi: 10.1016/j.lungcan.2018.07.016. PMID: 30268445

Diagnosis

Novel genetic characteristics in low-grade fetal adenocarcinoma of the lung.
Zhang S, Yin H, Zhang J, Yang L, Yang G, Jia J, Jiao Y, Ying J, Wang Y
Thorac Cancer 2021 Oct;12(20):2789-2795. Epub 2021 Aug 31 doi: 10.1111/1759-7714.14126. PMID: 34464028Free PMC Article
Morphologic, Immunohistochemical, and Genetic Differences Between High-grade and Low-grade Fetal Adenocarcinomas of the Lung.
Li Y, Xi SY, Yong JJ, Wu XY, Yang XH, Wang F
Am J Surg Pathol 2021 Nov 1;45(11):1464-1475. doi: 10.1097/PAS.0000000000001744. PMID: 34138800Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Therapy

Trastuzumab Deruxtecan: A Review in Gastric or Gastro-Oesophageal Junction Adenocarcinoma.
Kang C
Target Oncol 2023 Nov;18(6):981-989. Epub 2023 Oct 3 doi: 10.1007/s11523-023-00998-y. PMID: 37787931
LncRNA RP3-326I13.1 promotes cisplatin resistance in lung adenocarcinoma by binding to HSP90B and upregulating MMP13.
Zhou H, Huang X, Shi W, Xu S, Chen J, Huang K, Wang Y
Cell Cycle 2022 Jul;21(13):1391-1405. Epub 2022 Mar 17 doi: 10.1080/15384101.2022.2051971. PMID: 35298351Free PMC Article
Lung adenocarcinoma during pregnancy: clinical case and literature review.
Bellido C, Barbero P, Forcén L, Blanco M, Alonso-Riaño M, Galindo A
J Matern Fetal Neonatal Med 2019 Oct;32(19):3300-3302. Epub 2018 Apr 18 doi: 10.1080/14767058.2018.1461830. PMID: 29618241
Gene therapy of lung adenocarcinoma using herpes virus expressing a fusogenic membrane glycoprotein.
Zhu B, Yang JR, Jiang YQ, Chen SF, Fu XP
Cell Biochem Biophys 2014 Jul;69(3):583-7. doi: 10.1007/s12013-014-9836-4. PMID: 24510538
The clinical implications of isolated alpha(1) adrenergic stimulation.
Thiele RH, Nemergut EC, Lynch C 3rd
Anesth Analg 2011 Aug;113(2):297-304. Epub 2011 Apr 25 doi: 10.1213/ANE.0b013e3182120ca5. PMID: 21519053

Prognosis

Novel genetic characteristics in low-grade fetal adenocarcinoma of the lung.
Zhang S, Yin H, Zhang J, Yang L, Yang G, Jia J, Jiao Y, Ying J, Wang Y
Thorac Cancer 2021 Oct;12(20):2789-2795. Epub 2021 Aug 31 doi: 10.1111/1759-7714.14126. PMID: 34464028Free PMC Article
Adenocarcinoma classification: patterns and prognosis.
Kuhn E, Morbini P, Cancellieri A, Damiani S, Cavazza A, Comin CE
Pathologica 2018 Mar;110(1):5-11. PMID: 30259909
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Pulmonary blastomas.
Koss MN, Hochholzer L, O'Leary T
Cancer 1991 May 1;67(9):2368-81. doi: 10.1002/1097-0142(19910501)67:9<2368::aid-cncr2820670926>3.0.co;2-g. PMID: 1849449

Clinical prediction guides

Novel genetic characteristics in low-grade fetal adenocarcinoma of the lung.
Zhang S, Yin H, Zhang J, Yang L, Yang G, Jia J, Jiao Y, Ying J, Wang Y
Thorac Cancer 2021 Oct;12(20):2789-2795. Epub 2021 Aug 31 doi: 10.1111/1759-7714.14126. PMID: 34464028Free PMC Article
Morphologic, Immunohistochemical, and Genetic Differences Between High-grade and Low-grade Fetal Adenocarcinomas of the Lung.
Li Y, Xi SY, Yong JJ, Wu XY, Yang XH, Wang F
Am J Surg Pathol 2021 Nov 1;45(11):1464-1475. doi: 10.1097/PAS.0000000000001744. PMID: 34138800Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article
Pulmonary blastomas.
Koss MN, Hochholzer L, O'Leary T
Cancer 1991 May 1;67(9):2368-81. doi: 10.1002/1097-0142(19910501)67:9<2368::aid-cncr2820670926>3.0.co;2-g. PMID: 1849449

Recent systematic reviews

Wharton's Jelly Mesenchymal Stem Cell-Derived Extracellular Vesicles Reduce SARS-CoV2-Induced Inflammatory Cytokines Under High Glucose and Uremic Toxin Conditions.
Khanh VC, Fukushige M, Chang YH, Hoang NN, Yamashita T, Obata-Yasuoka M, Hamada H, Osaka M, Hiramatsu Y, Ohneda O
Stem Cells Dev 2021 Aug 1;30(15):758-772. Epub 2021 Jul 5 doi: 10.1089/scd.2021.0065. PMID: 34074129Free PMC Article
International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, Beer DG, Powell CA, Riely GJ, Van Schil PE, Garg K, Austin JH, Asamura H, Rusch VW, Hirsch FR, Scagliotti G, Mitsudomi T, Huber RM, Ishikawa Y, Jett J, Sanchez-Cespedes M, Sculier JP, Takahashi T, Tsuboi M, Vansteenkiste J, Wistuba I, Yang PC, Aberle D, Brambilla C, Flieder D, Franklin W, Gazdar A, Gould M, Hasleton P, Henderson D, Johnson B, Johnson D, Kerr K, Kuriyama K, Lee JS, Miller VA, Petersen I, Roggli V, Rosell R, Saijo N, Thunnissen E, Tsao M, Yankelewitz D
J Thorac Oncol 2011 Feb;6(2):244-85. doi: 10.1097/JTO.0b013e318206a221. PMID: 21252716Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...