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Gallbladder Clear Cell Adenocarcinoma

MedGen UID:
353726
•Concept ID:
C1708172
•
Neoplastic Process

Definition

A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells. The cells display hyperchromic nuclei and well-defined cytoplasmic borders. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGallbladder Clear Cell Adenocarcinoma

Professional guidelines

PubMed

The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.
Dundr P, Bazalová B, Bártů M, Bosse T, Drozenová J, Fabian P, Fadare O, Hausnerová J, Jakša R, Laco J, Lax SF, Matěj R, McCluggage WG, Méhes G, Michálková R, Němejcová K, Singh N, Stolnicu S, Škapa P, Švajdler M, Stružinská I
Virchows Arch 2022 Aug;481(2):201-212. Epub 2022 May 13 doi: 10.1007/s00428-022-03338-z. PMID: 35554675

Recent clinical studies

Etiology

Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis.
Hara S, Kijima H, Okada K, Igarashi Y
Biomed Res 2010 Apr;31(2):89-95. doi: 10.2220/biomedres.31.89. PMID: 20460736
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Unusual malignant epithelial tumors of the gallbladder.
Albores-Saavedra J, Molberg K, Henson DE
Semin Diagn Pathol 1996 Nov;13(4):326-38. PMID: 8946610

Diagnosis

The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.
Dundr P, Bazalová B, Bártů M, Bosse T, Drozenová J, Fabian P, Fadare O, Hausnerová J, Jakša R, Laco J, Lax SF, Matěj R, McCluggage WG, Méhes G, Michálková R, Němejcová K, Singh N, Stolnicu S, Škapa P, Švajdler M, Stružinská I
Virchows Arch 2022 Aug;481(2):201-212. Epub 2022 May 13 doi: 10.1007/s00428-022-03338-z. PMID: 35554675
Alpha-fetoprotein-producing clear cell carcinoma of the gallbladder with neuroendocrine differentiation.
Sentani K, Uraoka N, Oue N, Yasui W
Med Mol Morphol 2014 Mar;47(1):54-6. Epub 2013 Jul 17 doi: 10.1007/s00795-013-0049-5. PMID: 23860909
From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Clear cell carcinoma of the gallbladder. A histological and immunohistochemical study.
Bittinger A, Altekrüger I, Barth P
Pathol Res Pract 1995 Dec;191(12):1259-65; discussion 1266. doi: 10.1016/S0344-0338(11)81136-2. PMID: 8927575
Clear cell carcinomas of the gallbladder and extrahepatic bile ducts.
Vardaman C, Albores-Saavedra J
Am J Surg Pathol 1995 Jan;19(1):91-9. doi: 10.1097/00000478-199501000-00011. PMID: 7802141

Prognosis

The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.
Dundr P, Bazalová B, Bártů M, Bosse T, Drozenová J, Fabian P, Fadare O, Hausnerová J, Jakša R, Laco J, Lax SF, Matěj R, McCluggage WG, Méhes G, Michálková R, Němejcová K, Singh N, Stolnicu S, Škapa P, Švajdler M, Stružinská I
Virchows Arch 2022 Aug;481(2):201-212. Epub 2022 May 13 doi: 10.1007/s00428-022-03338-z. PMID: 35554675
Cytological features of hepatoid adenocarcinoma of the gallbladder: A case report with immunocytochemical analyzes.
Yoshioka S, Ishida M, Okano K, Sandoh K, Ebisu Y, Miyasaka C, Yamamoto T, Ryota H, Satoi S, Tsuta K
Diagn Cytopathol 2018 Aug;46(8):711-715. Epub 2018 Apr 10 doi: 10.1002/dc.23935. PMID: 29637715
Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis.
Hara S, Kijima H, Okada K, Igarashi Y
Biomed Res 2010 Apr;31(2):89-95. doi: 10.2220/biomedres.31.89. PMID: 20460736
Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma.
Kornprat P, Rehak P, Lemmerer M, Gogg-Kamerer M, Langner C
Virchows Arch 2005 May;446(5):505-10. Epub 2005 Apr 9 doi: 10.1007/s00428-005-1240-4. PMID: 15821928
Combined small cell carcinoma and clear cell carcinoma of the gallbladder: report of a case and review of the literature.
Piana S, Cavazza A, Corrado S, Putrino I, Gardini G
Pathol Res Pract 2002;198(12):821-4. doi: 10.1078/0344-0338-00341. PMID: 12608659

Clinical prediction guides

Enteroblastic cholangiocarcinoma: An uncommon, underrecognized subtype of bile duct cancer.
Chun J, Moore M, Kelly P, Kanzawa M, Itoh T, Hong SM, Zen Y
Hum Pathol 2024 Feb;144:46-52. Epub 2024 Jan 30 doi: 10.1016/j.humpath.2024.01.011. PMID: 38301963
The cytokeratin 17 expression in primary ovarian tumors has diagnostic but not prognostic significance.
Dundr P, Bazalová B, Bártů M, Bosse T, Drozenová J, Fabian P, Fadare O, Hausnerová J, Jakša R, Laco J, Lax SF, Matěj R, McCluggage WG, Méhes G, Michálková R, Němejcová K, Singh N, Stolnicu S, Škapa P, Švajdler M, Stružinská I
Virchows Arch 2022 Aug;481(2):201-212. Epub 2022 May 13 doi: 10.1007/s00428-022-03338-z. PMID: 35554675
Fetal gut-like differentiation in gallbladder cancer.
Koyama K, Maeda D, Tamura D, Narita C, Kudo-Asabe Y, Sato T, Yamamoto Y, Sageshima M, Nanjo H, Goto A
Hum Pathol 2017 Dec;70:27-34. Epub 2017 Sep 29 doi: 10.1016/j.humpath.2017.09.009. PMID: 28970139
Invasive micropapillary variant of the gallbladder adenocarcinoma and its aggressive potential for lymph node metastasis.
Hara S, Kijima H, Okada K, Igarashi Y
Biomed Res 2010 Apr;31(2):89-95. doi: 10.2220/biomedres.31.89. PMID: 20460736
Analysis of trefoil factor family protein 1 (TFF1, pS2) expression in chronic cholecystitis and gallbladder carcinoma.
Kornprat P, Rehak P, Lemmerer M, Gogg-Kamerer M, Langner C
Virchows Arch 2005 May;446(5):505-10. Epub 2005 Apr 9 doi: 10.1007/s00428-005-1240-4. PMID: 15821928

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