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Pleural sarcomatoid mesothelioma

MedGen UID:
354059
•Concept ID:
C1709578
•
Neoplastic Process
Synonyms: pleura sarcomatoid mesothelioma; Pleural Sarcomatoid Mesothelioma; pleural sarcomatoid mesothelioma; sarcomatoid mesothelioma of pleura
 
Monarch Initiative: MONDO:0006380

Definition

Malignant mesothelioma that arises from the pleura. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPleural sarcomatoid mesothelioma

Professional guidelines

PubMed

The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639
Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Takeshima Y, Amatya VJ, Kushitani K, Kaneko M, Inai K
Histopathology 2009 May;54(6):667-76. doi: 10.1111/j.1365-2559.2009.03298.x. PMID: 19438742

Recent clinical studies

Etiology

Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma.
Terra SBSP, Roden AC, Aubry MC, Yi ESJ, Boland JM
Arch Pathol Lab Med 2021 Feb 1;145(2):208-213. doi: 10.5858/arpa.2019-0647-OA. PMID: 33501493
Frequent expression of conventional endothelial markers in pleural mesothelioma: usefulness of claudin-5 as well as combined traditional markers to distinguish mesothelioma from angiosarcoma.
Nakashima Y, Inamura K, Ninomiya H, Okumura S, Mun M, Kirimura S, Kobayashi M, Okubo K, Ishikawa Y
Lung Cancer 2020 Oct;148:20-27. Epub 2020 Jul 30 doi: 10.1016/j.lungcan.2020.07.029. PMID: 32777673
Mesothelial and related neoplasms in children and adolescents: a clinicopathologic and immunohistochemical analysis of eight cases.
Coffin CM, Dehner LP
Pediatr Pathol 1992 May-Jun;12(3):333-47. doi: 10.3109/15513819209023314. PMID: 1384016

Diagnosis

Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma.
Terra SBSP, Roden AC, Aubry MC, Yi ESJ, Boland JM
Arch Pathol Lab Med 2021 Feb 1;145(2):208-213. doi: 10.5858/arpa.2019-0647-OA. PMID: 33501493
Frequent expression of conventional endothelial markers in pleural mesothelioma: usefulness of claudin-5 as well as combined traditional markers to distinguish mesothelioma from angiosarcoma.
Nakashima Y, Inamura K, Ninomiya H, Okumura S, Mun M, Kirimura S, Kobayashi M, Okubo K, Ishikawa Y
Lung Cancer 2020 Oct;148:20-27. Epub 2020 Jul 30 doi: 10.1016/j.lungcan.2020.07.029. PMID: 32777673
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Takeshima Y
Mod Pathol 2017 May;30(5):672-681. Epub 2017 Jan 27 doi: 10.1038/modpathol.2016.181. PMID: 28128276
Value of immunohistochemistry in the differential diagnosis of pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Takeshima Y, Amatya VJ, Kushitani K, Kaneko M, Inai K
Histopathology 2009 May;54(6):667-76. doi: 10.1111/j.1365-2559.2009.03298.x. PMID: 19438742

Therapy

The YAP1 Signaling Inhibitors, Verteporfin and CA3, Suppress the Mesothelioma Cancer Stem Cell Phenotype.
Kandasamy S, Adhikary G, Rorke EA, Friedberg JS, Mickle MB, Alexander HR, Eckert RL
Mol Cancer Res 2020 Mar;18(3):343-351. Epub 2019 Nov 15 doi: 10.1158/1541-7786.MCR-19-0914. PMID: 31732616Free PMC Article

Prognosis

The YAP1 Signaling Inhibitors, Verteporfin and CA3, Suppress the Mesothelioma Cancer Stem Cell Phenotype.
Kandasamy S, Adhikary G, Rorke EA, Friedberg JS, Mickle MB, Alexander HR, Eckert RL
Mol Cancer Res 2020 Mar;18(3):343-351. Epub 2019 Nov 15 doi: 10.1158/1541-7786.MCR-19-0914. PMID: 31732616Free PMC Article
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Takeshima Y
Mod Pathol 2017 May;30(5):672-681. Epub 2017 Jan 27 doi: 10.1038/modpathol.2016.181. PMID: 28128276
Mesothelial and related neoplasms in children and adolescents: a clinicopathologic and immunohistochemical analysis of eight cases.
Coffin CM, Dehner LP
Pediatr Pathol 1992 May-Jun;12(3):333-47. doi: 10.3109/15513819209023314. PMID: 1384016

Clinical prediction guides

Utility of Immunohistochemistry for MUC4 and GATA3 to Aid in the Distinction of Pleural Sarcomatoid Mesothelioma From Pulmonary Sarcomatoid Carcinoma.
Terra SBSP, Roden AC, Aubry MC, Yi ESJ, Boland JM
Arch Pathol Lab Med 2021 Feb 1;145(2):208-213. doi: 10.5858/arpa.2019-0647-OA. PMID: 33501493
The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639
MUC4, a novel immunohistochemical marker identified by gene expression profiling, differentiates pleural sarcomatoid mesothelioma from lung sarcomatoid carcinoma.
Amatya VJ, Kushitani K, Mawas AS, Miyata Y, Okada M, Kishimoto T, Inai K, Takeshima Y
Mod Pathol 2017 May;30(5):672-681. Epub 2017 Jan 27 doi: 10.1038/modpathol.2016.181. PMID: 28128276

Recent systematic reviews

The differential diagnosis between pleural sarcomatoid mesothelioma and spindle cell/pleomorphic (sarcomatoid) carcinomas of the lung: evidence-based guidelines from the International Mesothelioma Panel and the MESOPATH National Reference Center.
Marchevsky AM, LeStang N, Hiroshima K, Pelosi G, Attanoos R, Churg A, Chirieac L, Dacic S, Husain A, Khoor A, Klebe S, Lantuejoul S, Roggli V, Vignaud JM, Weynard B, Sauter J, Henderson D, Nabeshima K, Galateau-Salle F
Hum Pathol 2017 Sep;67:160-168. Epub 2017 Aug 4 doi: 10.1016/j.humpath.2017.07.015. PMID: 28782639

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