U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

New York Heart Association Class IV

MedGen UID:
362154
Concept ID:
C1882087
Finding
Synonym: NYHA Class IV

Definition

A finding associated with a patient with defined or presumed cardiac disease with inability to carry on any physical activity without discomfort. Symptoms are present even at rest or minimal exertion. (from The Criteria Committee of the New York Heart Association. Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. 9th ed. Boston, Mass: Little, Brown & Co; 1994:253-256.) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNew York Heart Association Class IV

Professional guidelines

PubMed

Chang YK, Kaplan H, Geng Y, Mo L, Philip J, Collins A, Allen LA, McClung JA, Denvir MA, Hui D
Circ Heart Fail 2020 Sep;13(9):e006881. Epub 2020 Sep 9 doi: 10.1161/CIRCHEARTFAILURE.120.006881. PMID: 32900233Free PMC Article
Al-Mohammad A
ESC Heart Fail 2019 Aug;6(4):878-883. Epub 2019 May 22 doi: 10.1002/ehf2.12459. PMID: 31119890Free PMC Article
Quaglietti SE, Atwood JE, Ackerman L, Froelicher V
Prog Cardiovasc Dis 2000 Nov-Dec;43(3):259-74. doi: 10.1053/pcad.2000.19803. PMID: 11153512

Recent clinical studies

Etiology

Vader JM, Givertz MM, Starling RC, McNulty SE, Anstrom KJ, Desvigne-Nickens P, Hernandez AF, Braunwald E, Mann DL; LIFE Investigators
JACC Heart Fail 2022 Jul;10(7):449-456. doi: 10.1016/j.jchf.2022.04.013. PMID: 35772853
Wasilewski G, Kędziora A, Górkiewicz-Kot I, Stąpór M, Hymczak H, Wierzbicki K
Transplant Proc 2022 May;54(4):1054-1057. Epub 2022 May 7 doi: 10.1016/j.transproceed.2022.02.052. PMID: 35534280
Mann DL, Givertz MM, Vader JM, Starling RC, Shah P, McNulty SE, Anstrom KJ, Margulies KB, Kiernan MS, Mahr C, Gupta D, Redfield MM, Lala A, Lewis GD, DeVore AD, Desvigne-Nickens P, Hernandez AF, Braunwald E; LIFE Investigators
JAMA Cardiol 2022 Jan 1;7(1):17-25. doi: 10.1001/jamacardio.2021.4567. PMID: 34730769Free PMC Article
Nashef SA, Roques F, Sharples LD, Nilsson J, Smith C, Goldstone AR, Lockowandt U
Eur J Cardiothorac Surg 2012 Apr;41(4):734-44; discussion 744-5. Epub 2012 Feb 29 doi: 10.1093/ejcts/ezs043. PMID: 22378855
Spies CD, Sander M, Stangl K, Fernandez-Sola J, Preedy VR, Rubin E, Andreasson S, Hanna EZ, Kox WJ
Curr Opin Crit Care 2001 Oct;7(5):337-43. doi: 10.1097/00075198-200110000-00004. PMID: 11805530

Diagnosis

Romero J, Gabr M, Alviz I, Briceno D, Diaz JC, Rodriguez D, Patel K, Polanco D, Trivedi C, Mohanty S, Della Rocca D, Lakkireddy D, Natale A, Di Biase L
J Cardiovasc Electrophysiol 2022 Nov;33(11):2356-2366. Epub 2022 Aug 10 doi: 10.1111/jce.15622. PMID: 35842804
Stevenson LW, Pagani FD, Young JB, Jessup M, Miller L, Kormos RL, Naftel DC, Ulisney K, Desvigne-Nickens P, Kirklin JK
J Heart Lung Transplant 2009 Jun;28(6):535-41. doi: 10.1016/j.healun.2009.02.015. PMID: 19481012
Macdonald PS, Keogh AM, Aboyoun CL, Lund M, Amor R, McCaffrey DJ
J Am Coll Cardiol 1999 Mar 15;33(4):924-31. doi: 10.1016/s0735-1097(98)00680-9. PMID: 10091817
Patterson JH, Adams KF Jr
Pharmacotherapy 1993 Sep-Oct;13(5 Pt 2):73S-81S. PMID: 8233996
Rider AK, Copeland JG, Hunt SA, Mason J, Specter MJ, Winkle RA, Bieber CP, Billingham ME, Dong E Jr, Griepp RB, Schroeder JS, Stinson EB, Harrison DC, Shumway NE
Circulation 1975 Oct;52(4):531-9. doi: 10.1161/01.cir.52.4.531. PMID: 1098809

Therapy

Vader JM, Givertz MM, Starling RC, McNulty SE, Anstrom KJ, Desvigne-Nickens P, Hernandez AF, Braunwald E, Mann DL; LIFE Investigators
JACC Heart Fail 2022 Jul;10(7):449-456. doi: 10.1016/j.jchf.2022.04.013. PMID: 35772853
Wasilewski G, Kędziora A, Górkiewicz-Kot I, Stąpór M, Hymczak H, Wierzbicki K
Transplant Proc 2022 May;54(4):1054-1057. Epub 2022 May 7 doi: 10.1016/j.transproceed.2022.02.052. PMID: 35534280
Mann DL, Givertz MM, Vader JM, Starling RC, Shah P, McNulty SE, Anstrom KJ, Margulies KB, Kiernan MS, Mahr C, Gupta D, Redfield MM, Lala A, Lewis GD, DeVore AD, Desvigne-Nickens P, Hernandez AF, Braunwald E; LIFE Investigators
JAMA Cardiol 2022 Jan 1;7(1):17-25. doi: 10.1001/jamacardio.2021.4567. PMID: 34730769Free PMC Article
Nashef SA, Roques F, Sharples LD, Nilsson J, Smith C, Goldstone AR, Lockowandt U
Eur J Cardiothorac Surg 2012 Apr;41(4):734-44; discussion 744-5. Epub 2012 Feb 29 doi: 10.1093/ejcts/ezs043. PMID: 22378855
Castel MA, Magnani S, Mont L, Roig E, Tamborero D, Méndez-Zurita F, Femenia JF, Tolosana JM, Pérez-Villa F, Brugada J
Europace 2010 Aug;12(8):1136-40. Epub 2010 Jun 12 doi: 10.1093/europace/euq163. PMID: 20543199

Prognosis

Vader JM, Givertz MM, Starling RC, McNulty SE, Anstrom KJ, Desvigne-Nickens P, Hernandez AF, Braunwald E, Mann DL; LIFE Investigators
JACC Heart Fail 2022 Jul;10(7):449-456. doi: 10.1016/j.jchf.2022.04.013. PMID: 35772853
Lee SS, Kwon HJ, Park KM, On YK, Kim JS, Park SJ
ESC Heart Fail 2020 Oct;7(5):3109-3118. Epub 2020 Aug 13 doi: 10.1002/ehf2.12940. PMID: 32790157Free PMC Article
Chinitz JS, d'Avila A, Goldman M, Reddy V, Dukkipati S
Ann Glob Health 2014 Jan-Feb;80(1):61-8. Epub 2013 Dec 25 doi: 10.1016/j.aogh.2013.12.003. PMID: 24751566
Nashef SA, Roques F, Sharples LD, Nilsson J, Smith C, Goldstone AR, Lockowandt U
Eur J Cardiothorac Surg 2012 Apr;41(4):734-44; discussion 744-5. Epub 2012 Feb 29 doi: 10.1093/ejcts/ezs043. PMID: 22378855
Stevenson LW, Pagani FD, Young JB, Jessup M, Miller L, Kormos RL, Naftel DC, Ulisney K, Desvigne-Nickens P, Kirklin JK
J Heart Lung Transplant 2009 Jun;28(6):535-41. doi: 10.1016/j.healun.2009.02.015. PMID: 19481012

Clinical prediction guides

Vader JM, Givertz MM, Starling RC, McNulty SE, Anstrom KJ, Desvigne-Nickens P, Hernandez AF, Braunwald E, Mann DL; LIFE Investigators
JACC Heart Fail 2022 Jul;10(7):449-456. doi: 10.1016/j.jchf.2022.04.013. PMID: 35772853
Mann DL, Givertz MM, Vader JM, Starling RC, Shah P, McNulty SE, Anstrom KJ, Margulies KB, Kiernan MS, Mahr C, Gupta D, Redfield MM, Lala A, Lewis GD, DeVore AD, Desvigne-Nickens P, Hernandez AF, Braunwald E; LIFE Investigators
JAMA Cardiol 2022 Jan 1;7(1):17-25. doi: 10.1001/jamacardio.2021.4567. PMID: 34730769Free PMC Article
Cai A, Miyazawa A, Sunderland N, Piper SE, Gibbs TGJ, Wang D, Redding S, Amin-Youseff G, Wendler O, Byrne J, MacCarthy PA, Shah AM, McDonagh TA, Dworakowski R
Cardiol J 2021;28(1):129-135. Epub 2019 Jun 21 doi: 10.5603/CJ.a2019.0052. PMID: 31225635Free PMC Article
Chinitz JS, d'Avila A, Goldman M, Reddy V, Dukkipati S
Ann Glob Health 2014 Jan-Feb;80(1):61-8. Epub 2013 Dec 25 doi: 10.1016/j.aogh.2013.12.003. PMID: 24751566
Nashef SA, Roques F, Sharples LD, Nilsson J, Smith C, Goldstone AR, Lockowandt U
Eur J Cardiothorac Surg 2012 Apr;41(4):734-44; discussion 744-5. Epub 2012 Feb 29 doi: 10.1093/ejcts/ezs043. PMID: 22378855

Recent systematic reviews

Romero J, Gabr M, Alviz I, Briceno D, Diaz JC, Rodriguez D, Patel K, Polanco D, Trivedi C, Mohanty S, Della Rocca D, Lakkireddy D, Natale A, Di Biase L
J Cardiovasc Electrophysiol 2022 Nov;33(11):2356-2366. Epub 2022 Aug 10 doi: 10.1111/jce.15622. PMID: 35842804
Chang YK, Kaplan H, Geng Y, Mo L, Philip J, Collins A, Allen LA, McClung JA, Denvir MA, Hui D
Circ Heart Fail 2020 Sep;13(9):e006881. Epub 2020 Sep 9 doi: 10.1161/CIRCHEARTFAILURE.120.006881. PMID: 32900233Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...