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Skin Nodular Solid Basal Cell Carcinoma

MedGen UID:
362653
•Concept ID:
C1879347
•
Neoplastic Process
Synonym: Circumscribed solid basal cell carcinoma
SNOMED CT: Circumscribed solid basal cell carcinoma (403910009)

Definition

A basal cell carcinoma often presenting as elevated skin nodules which may become ulcerated or cystic. In cases which present as endophytic nodules, the overlying skin surface shows indurated flat lesions. It occurs most frequently on the head. Morphologically, the neoplastic basaloid cells form lobules with peripheral nuclear palisading. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSkin Nodular Solid Basal Cell Carcinoma

Recent clinical studies

Etiology

Optical coherence tomography-guided Nd:YAG laser treatment and follow-up of basal cell carcinoma.
Kranz S, Brunnmeier G, Yilmaz P, Thamm J, Schiele S, Müller G, Key C, Welzel J, Schuh S
Lasers Surg Med 2023 Mar;55(3):257-267. Epub 2023 Feb 5 doi: 10.1002/lsm.23638. PMID: 36740365
Nicotinamide N-methyltransferase in nonmelanoma skin cancers.
Pompei V, Salvolini E, Rubini C, Lucarini G, Molinelli E, Brisigotti V, Pozzi V, Sartini D, Campanati A, Offidani A, Emanuelli M
Eur J Clin Invest 2019 Dec;49(12):e13175. Epub 2019 Oct 26 doi: 10.1111/eci.13175. PMID: 31571214
Macrophage subtypes in recurrent nodular basal cell carcinoma after Mohs micrographic surgery.
Padoveze EH, Chiacchio ND, Ocampo-Garza J, Cernea SS, Belda W, Sotto MN
Int J Dermatol 2017 Dec;56(12):1366-1372. Epub 2017 Oct 9 doi: 10.1111/ijd.13790. PMID: 28994114
Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α.
Wettstein R, Erba P, Itin P, Schaefer DJ, Kalbermatten DF
J Plast Reconstr Aesthet Surg 2013 Jul;66(7):912-6. Epub 2013 Apr 6 doi: 10.1016/j.bjps.2013.03.008. PMID: 23566745
5 years review of periocular basal cell carcinoma and proposed follow-up protocol.
Ho SF, Brown L, Bamford M, Sampath R, Burns J
Eye (Lond) 2013 Jan;27(1):78-83. Epub 2012 Nov 16 doi: 10.1038/eye.2012.230. PMID: 23154501Free PMC Article

Diagnosis

Optical coherence tomography-guided Nd:YAG laser treatment and follow-up of basal cell carcinoma.
Kranz S, Brunnmeier G, Yilmaz P, Thamm J, Schiele S, Müller G, Key C, Welzel J, Schuh S
Lasers Surg Med 2023 Mar;55(3):257-267. Epub 2023 Feb 5 doi: 10.1002/lsm.23638. PMID: 36740365
In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study.
Jerjes W, Hamdoon Z, Rashed D, Sattar AA, Hopper C
Photodiagnosis Photodyn Ther 2021 Dec;36:102493. Epub 2021 Aug 20 doi: 10.1016/j.pdpdt.2021.102493. PMID: 34419675
PIGMENTED NODULAR CYSTIC HIDRADENOMA OF THE ANKLE.
Wollina U, Schönlebe J, Goldman A
Georgian Med News 2021 Jun;(315):7-9. PMID: 34365416
CARCINOSARCOMA OF SKIN (SARCOMATOID CARCINOMA) - A RARE NON-MELANOMA SKIN CANCER (CASE REVIEW).
Wollina U, Koch A, Schönlebe J, Tchernev G
Georgian Med News 2017 Feb;(263):7-10. PMID: 28452720
Trichoadenoma of the upper lip.
Bombeccari GP, Guzzi G, Mariani U, Gianatti A, Ruffoni D, Santoro F, Spadari F
Stomatologija 2015;17(3):102-4. PMID: 26879403

Therapy

Optical coherence tomography-guided Nd:YAG laser treatment and follow-up of basal cell carcinoma.
Kranz S, Brunnmeier G, Yilmaz P, Thamm J, Schiele S, Müller G, Key C, Welzel J, Schuh S
Lasers Surg Med 2023 Mar;55(3):257-267. Epub 2023 Feb 5 doi: 10.1002/lsm.23638. PMID: 36740365
Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial.
Choi SH, Kim KH, Song KH
J Eur Acad Dermatol Venereol 2016 May;30(5):783-8. Epub 2015 Nov 9 doi: 10.1111/jdv.13453. PMID: 26551044
Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α.
Wettstein R, Erba P, Itin P, Schaefer DJ, Kalbermatten DF
J Plast Reconstr Aesthet Surg 2013 Jul;66(7):912-6. Epub 2013 Apr 6 doi: 10.1016/j.bjps.2013.03.008. PMID: 23566745
Photodynamic therapy for basal cell carcinomas in organ-transplant recipients.
Guleng GE, Helsing P
Clin Exp Dermatol 2012 Jun;37(4):367-9. Epub 2012 Mar 15 doi: 10.1111/j.1365-2230.2011.04248.x. PMID: 22420420
Combination of Er:YAG laser and photodynamic therapy in the treatment of nodular basal cell carcinoma.
Smucler R, Vlk M
Lasers Surg Med 2008 Feb;40(2):153-8. doi: 10.1002/lsm.20606. PMID: 18306163

Prognosis

Optical coherence tomography-guided Nd:YAG laser treatment and follow-up of basal cell carcinoma.
Kranz S, Brunnmeier G, Yilmaz P, Thamm J, Schiele S, Müller G, Key C, Welzel J, Schuh S
Lasers Surg Med 2023 Mar;55(3):257-267. Epub 2023 Feb 5 doi: 10.1002/lsm.23638. PMID: 36740365
Comparative Analyses of Tumour Volume Doubling Times for Periocular and Non-periocular Head and Neck Basal Cell Carcinomas.
Khoo ABS, Goon PKC, Sudhoff H, Goon PKC
Acta Derm Venereol 2019 Dec 1;99(13):1266-1269. doi: 10.2340/00015555-3325. PMID: 31573662
Nicotinamide N-methyltransferase in nonmelanoma skin cancers.
Pompei V, Salvolini E, Rubini C, Lucarini G, Molinelli E, Brisigotti V, Pozzi V, Sartini D, Campanati A, Offidani A, Emanuelli M
Eur J Clin Invest 2019 Dec;49(12):e13175. Epub 2019 Oct 26 doi: 10.1111/eci.13175. PMID: 31571214
Superficial basal cell carcinoma: A comparison of superficial only subtype with superficial combined with other subtypes by age, sex and anatomic site in 3150 cases.
Pyne JH, Myint E, Barr EM, Clark SP, David M, Na R, Hou R
J Cutan Pathol 2017 Aug;44(8):677-683. Epub 2017 Jun 7 doi: 10.1111/cup.12959. PMID: 28493477
Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α.
Wettstein R, Erba P, Itin P, Schaefer DJ, Kalbermatten DF
J Plast Reconstr Aesthet Surg 2013 Jul;66(7):912-6. Epub 2013 Apr 6 doi: 10.1016/j.bjps.2013.03.008. PMID: 23566745

Clinical prediction guides

In vivo optical coherence tomography in assessment of suspicious facial lesions: A prospective study.
Jerjes W, Hamdoon Z, Rashed D, Sattar AA, Hopper C
Photodiagnosis Photodyn Ther 2021 Dec;36:102493. Epub 2021 Aug 20 doi: 10.1016/j.pdpdt.2021.102493. PMID: 34419675
Treatment of basal cell carcinoma with surgical excision and perilesional interferon-α.
Wettstein R, Erba P, Itin P, Schaefer DJ, Kalbermatten DF
J Plast Reconstr Aesthet Surg 2013 Jul;66(7):912-6. Epub 2013 Apr 6 doi: 10.1016/j.bjps.2013.03.008. PMID: 23566745
755 nm alexandrite laser for the reduction of tumor burden in basal cell Nevus syndrome.
Ibrahimi OA, Sakamoto FH, Tannous Z, Anderson RR
Lasers Surg Med 2011 Feb;43(2):68-71. doi: 10.1002/lsm.20953. PMID: 21384386
Basal cell carcinoma in childhood: case report and literature review.
Griffin JR, Cohen PR, Tschen JA, Mullans EA, Schulze KE, Martinelli PT, Nelson BR
J Am Acad Dermatol 2007 Nov;57(5 Suppl):S97-102. doi: 10.1016/j.jaad.2006.09.032. PMID: 17938034
Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma.
Yamamoto O, Asahi M
Br J Dermatol 1999 Jan;140(1):8-16. doi: 10.1046/j.1365-2133.1999.02601.x. PMID: 10215762

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