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Malignant lymphoma, centroblastic type, follicular

MedGen UID:: 36334
•Concept ID:: C0079745
•: Neoplastic Process

Synonyms:

Follicular Large Cell Lymphoma; Follicular Large-Cell Lymphoma; Follicular Large-Cell Lymphomas; Histiocytic Lymphoma, Nodular; Histiocytic Lymphomas, Nodular; Large Cell Lymphoma, Follicular; Large Lymphoid Lymphoma, Nodular; Large-Cell Lymphoma, Follicular; Large-Cell Lymphomas, Follicular; Lymphoma, Follicular Large Cell; Lymphoma, Follicular Large-Cell; Lymphoma, Histiocytic, Nodular; Lymphoma, Large Cell, Follicular; Lymphoma, Large Lymphoid, Nodular; Lymphoma, Large-Cell, Follicular; Lymphoma, Nodular Histiocytic; Lymphoma, Nodular, Large Follicular Center Cell; Lymphoma, Nodular, Large Follicular Center-Cell; Lymphomas, Follicular Large-Cell; Lymphomas, Nodular Histiocytic; Nodular Histiocytic Lymphoma; Nodular Histiocytic Lymphomas; Nodular Large Follicular Center Cell Lymphoma; Nodular Large Follicular Center-Cell Lymphoma

SNOMED CT:

Malignant lymphoma, centroblastic, follicular (40411000); Malignant lymphoma, centroblastic type, follicular (307647008); Germinoblastic sarcoma, follicular (307647008); Malignant lymphoma, large cell, follicular (40411000); Malignant lymphoma, large cell, noncleaved, follicular (40411000); Malignant lymphoma, histiocytic, nodular (40411000); Malignant lymphoma, large cleaved cell, follicular (40411000); Malignant lymphoma, noncleaved, follicular (40411000)

Definition

An antiquated term that refers to a follicular non-Hodgkin lymphoma composed predominantly of large B-lymphocytes. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant lymphoma, centroblastic type, follicular

Hematologic neoplasm
- Lymphoma
  - Non-Hodgkin lymphoma
    - Non-Hodgkin Lymphoma by Clinical Course
      - Aggressive Non-Hodgkin Lymphoma
        Aggressive B-cell non-Hodgkin lymphoma
        Malignant lymphoma, centroblastic type, follicular
        Ann Arbor Stage I Grade 3 Follicular Lymphoma
        Ann Arbor Stage II Grade 3 Follicular Lymphoma
        Ann Arbor Stage II Grade 3 Contiguous Follicular Lymphoma
        Ann Arbor Stage II Grade 3 Non-Contiguous Follicular Lymphoma
        Ann Arbor Stage III Grade 3 Follicular Lymphoma
        Ann Arbor Stage IV Grade 3 Follicular Lymphoma
        Grade 3 Cutaneous Follicular Lymphoma
        Grade 3a Follicular Lymphoma
        Recurrent Grade 3a Follicular Lymphoma
        Refractory Grade 3a Follicular Lymphoma
        Grade 3b Follicular Lymphoma
        Recurrent Grade 3b Follicular Lymphoma
        Refractory Grade 3b Follicular Lymphoma
        Recurrent Grade 3 Follicular Lymphoma
        Refractory Grade 3 Follicular Lymphoma
        Stage I Centroblastic Follicular Lymphoma
        Stage II Centroblastic Follicular Lymphoma

Professional guidelines

PubMed

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA).

Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I
Ann Oncol 2022 Mar;33(3):259-275. Epub 2021 Dec 16 doi: 10.1016/j.annonc.2021.12.003. PMID: 34923107

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

See all (732)

Recent clinical studies

Etiology

Update on follicular lymphoma.

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960 Free PMC Article

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Epidemiology of Follicular Lymphoma.

Cerhan JR
Hematol Oncol Clin North Am 2020 Aug;34(4):631-646. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.02.001. PMID: 32586570 Free PMC Article

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Transformed follicular lymphoma.

Fischer T, Zing NPC, Chiattone CS, Federico M, Luminari S
Ann Hematol 2018 Jan;97(1):17-29. Epub 2017 Oct 18 doi: 10.1007/s00277-017-3151-2. PMID: 29043381

See all (3822)

Diagnosis

Update on follicular lymphoma.

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960 Free PMC Article

Follicular lymphoma and marginal zone lymphoma: how many diseases?

Laurent C, Cook JR, Yoshino T, Quintanilla-Martinez L, Jaffe ES
Virchows Arch 2023 Jan;482(1):149-162. Epub 2022 Nov 17 doi: 10.1007/s00428-022-03432-2. PMID: 36394631 Free PMC Article

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Follicular lymphoma: an update on diagnosis, prognosis, and management.

Mozas P, Sorigué M, López-Guillermo A
Med Clin (Barc) 2021 Nov 12;157(9):440-448. Epub 2021 Jun 29 doi: 10.1016/j.medcli.2021.03.041. PMID: 34210513

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

See all (4611)

Therapy

Follicular lymphoma: The long and winding road leading to your cure?

Gordon MJ, Smith MR, Nastoupil LJ
Blood Rev 2023 Jan;57:100992. Epub 2022 Jul 23 doi: 10.1016/j.blre.2022.100992. PMID: 35908982

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Dreyling M, Ghielmini M, Rule S, Salles G, Ladetto M, Tonino SH, Herfarth K, Seymour JF, Jerkeman M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Mar;32(3):298-308. Epub 2020 Nov 26 doi: 10.1016/j.annonc.2020.11.008. PMID: 33249059

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

Follicular lymphoma.

Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752

See all (3612)

Prognosis

Update on follicular lymphoma.

Friedberg JW
Hematol Oncol 2023 Jun;41 Suppl 1(Suppl 1):43-47. doi: 10.1002/hon.3138. PMID: 37294960 Free PMC Article

Follicular lymphoma: an update on diagnosis, prognosis, and management.

Mozas P, Sorigué M, López-Guillermo A
Med Clin (Barc) 2021 Nov 12;157(9):440-448. Epub 2021 Jun 29 doi: 10.1016/j.medcli.2021.03.041. PMID: 34210513

Newly diagnosed and relapsed follicular lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Epidemiology of Follicular Lymphoma.

Cerhan JR
Hematol Oncol Clin North Am 2020 Aug;34(4):631-646. Epub 2020 May 5 doi: 10.1016/j.hoc.2020.02.001. PMID: 32586570 Free PMC Article

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

See all (3721)

Clinical prediction guides

Follicular lymphoma: 2023 update on diagnosis and management.

Jacobsen E
Am J Hematol 2022 Dec;97(12):1638-1651. Epub 2022 Oct 18 doi: 10.1002/ajh.26737. PMID: 36255040

Treatment patterns and outcomes of patients with relapsed or refractory follicular lymphoma receiving three or more lines of systemic therapy (LEO CReWE): a multicentre cohort study.

Casulo C, Larson MC, Lunde JJ, Habermann TM, Lossos IS, Wang Y, Nastoupil LJ, Strouse C, Chihara D, Martin P, Cohen JB, Kahl BS, Burack WR, Koff JL, Mun Y, Masaquel A, Wu M, Wei MC, Shewade A, Li J, Cerhan J, Flowers CR, Link BK, Maurer MJ
Lancet Haematol 2022 Apr;9(4):e289-e300. doi: 10.1016/S2352-3026(22)00033-3. PMID: 35358443 Free PMC Article

Validation of POD24 as a robust early clinical end point of poor survival in FL from 5225 patients on 13 clinical trials.

Casulo C, Dixon JG, Le-Rademacher J, Hoster E, Hochster HS, Hiddemann W, Marcus R, Kimby E, Herold M, Sebban C, Gyan E, Foon K, Nielsen T, Vitolo U, Salles GA, Shi Q, Flowers CR
Blood 2022 Mar 17;139(11):1684-1693. doi: 10.1182/blood.2020010263. PMID: 34614146 Free PMC Article

Follicular lymphoma in the modern era: survival, treatment outcomes, and identification of high-risk subgroups.

Batlevi CL, Sha F, Alperovich A, Ni A, Smith K, Ying Z, Soumerai JD, Caron PC, Falchi L, Hamilton A, Hamlin PA, Horwitz SM, Joffe E, Kumar A, Matasar MJ, Moskowitz AJ, Moskowitz CH, Noy A, Owens C, Palomba LM, Straus D, von Keudell G, Zelenetz AD, Seshan VE, Younes A
Blood Cancer J 2020 Jul 17;10(7):74. doi: 10.1038/s41408-020-00340-z. PMID: 32678074 Free PMC Article

Follicular lymphoma: 2020 update on diagnosis and management.

Freedman A, Jacobsen E
Am J Hematol 2020 Mar;95(3):316-327. Epub 2019 Dec 22 doi: 10.1002/ajh.25696. PMID: 31814159

See all (2871)

Recent systematic reviews

Late relapse after CAR-T cell therapy for adult patients with hematologic malignancies: A definite evidence from systematic review and meta-analysis on individual data.

Zinzi A, Gaio M, Liguori V, Cagnotta C, Paolino D, Paolisso G, Castaldo G, Nicoletti GF, Rossi F, Capuano A, Rafaniello C
Pharmacol Res 2023 Apr;190:106742. Epub 2023 Mar 22 doi: 10.1016/j.phrs.2023.106742. PMID: 36963592

A systematic review and meta-analysis of occupational exposures and risk of follicular lymphoma.

Odutola MK, Benke G, Fritschi L, Giles GG, van Leeuwen MT, Vajdic CM
Environ Res 2021 Jun;197:110887. Epub 2021 Feb 17 doi: 10.1016/j.envres.2021.110887. PMID: 33607095

Human Pegivirus Infection and Lymphoma Risk: A Systematic Review and Meta-analysis.

Fama A, Larson MC, Link BK, Habermann TM, Feldman AL, Call TG, Ansell SM, Liebow M, Xiang J, Maurer MJ, Slager SL, Nowakowski GS, Stapleton JT, Cerhan JR
Clin Infect Dis 2020 Aug 22;71(5):1221-1228. doi: 10.1093/cid/ciz940. PMID: 31671178 Free PMC Article

Prognostic value of interim and end-of-treatment FDG-PET in follicular lymphoma: a systematic review.

Adams HJA, Nievelstein RAJ, Kwee TC
Ann Hematol 2016 Jan;95(1):11-18. Epub 2015 Nov 18 doi: 10.1007/s00277-015-2553-2. PMID: 26576560 Free PMC Article

Randomized controlled trials in relapsed/refractory follicular lymphoma: a systematic review and meta-analysis.

Police RL, Trask PC, Wang J, Olivares R, Khan S, Abbe A, Colosia A, Njue A, Sherril B, Ruiz-Soto R, Kaye JA, Hamadani M
J Oncol Pharm Pract 2016 Oct;22(5):666-78. Epub 2015 Aug 28 doi: 10.1177/1078155215603230. PMID: 26320127

See all (76)

MedGen

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Malignant lymphoma, centroblastic type, follicular

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity