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Metastatic Signet Ring Cell Carcinoma

MedGen UID:
364045
•Concept ID:
C1881801
•
Neoplastic Process
Synonyms: Metastatic signet ring cell carcinoma; Metastatic Signet-Ring Cell Carcinoma
SNOMED CT: Metastatic signet ring cell carcinoma (4305004)

Definition

A signet ring cell carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Signet Ring Cell Carcinoma

Professional guidelines

PubMed

Decision-making in postoperative chemotherapy for ovarian metastasis from colorectal cancer: a retrospective single-center study.
Hamasaki S, Fukunaga Y, Nagayama S, Fujimoto Y, Akiyoshi T, Nagasaki T, Ueno M
World J Surg Oncol 2022 Feb 1;20(1):28. doi: 10.1186/s12957-022-02498-1. PMID: 35105353Free PMC Article
Clinical features, treatment, and prognosis of different histological types of primary small bowel adenocarcinoma: A propensity score matching analysis based on the SEER database.
Zhou YW, Xia RL, Chen YY, Ma XL, Liu JY
Eur J Surg Oncol 2021 Aug;47(8):2108-2118. Epub 2021 Apr 2 doi: 10.1016/j.ejso.2021.03.260. PMID: 33849741
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article

Recent clinical studies

Etiology

Ovarian malignant Mullerian mixed tumor (heterologous) whose epithelial component is composed predominantly of signet ring cell carcinoma.
Terada T
Arch Gynecol Obstet 2011 Jun;283(6):1403-6. Epub 2010 Jul 23 doi: 10.1007/s00404-010-1591-1. PMID: 20652287
Signet-ring stromal tumor of the testis: a case report and literature review.
Kuo CY, Wen MC, Wang J, Jan YJ
Hum Pathol 2009 Apr;40(4):584-7. Epub 2008 Oct 5 doi: 10.1016/j.humpath.2008.07.012. PMID: 18835626
Clinicopathologic analysis of solid papillary carcinoma of the breast and associated invasive carcinomas.
Nassar H, Qureshi H, Adsay NV, Visscher D
Am J Surg Pathol 2006 Apr;30(4):501-7. doi: 10.1097/00000478-200604000-00011. PMID: 16625097
Signet ring cell carcinoma of the breast as a source of pelvic floor metastatic mass. A case report.
Colak T, Akca T, Dirlik M, Caglikulekci M, Seyrek E, Cinel L, Bozdogan R, Aydin S
Acta Chir Belg 2005 Apr;105(2):224-6. PMID: 15906923

Diagnosis

Pseudoachalasia as the first manifestation of signet-ring cell duodenal carcinoma.
Trad N, Bel Hadj Mabrouk E, Mensi A, Zaimi Y, Ksantini M, Said Y
Tunis Med 2023 Feb 12;101(2):317-320. PMID: 37682279
Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report.
Zhang L, Min Q, Bi J, Yu X, Liang Y, Shao M
BMC Womens Health 2023 Mar 23;23(1):119. doi: 10.1186/s12905-023-02285-4. PMID: 36949419Free PMC Article
Signet ring cell carcinoma of bladder: a dilemma between primary and metastatic.
Nisa Z
BMJ Case Rep 2021 Nov 30;14(11) doi: 10.1136/bcr-2021-246374. PMID: 34848423Free PMC Article
Metastatic Signet-Ring Cell Carcinoma of the Bladder in Cerebrospinal Fluid.
Lin DM, Park JW, Gattuso P
Diagn Cytopathol 2017 Jan;45(1):73-76. Epub 2016 Sep 15 doi: 10.1002/dc.23603. PMID: 27629260
Metastatic signet-ring cell carcinoma of unknown primary origin.
Gregoire C, Muller G, Machiels JP, Goeminne JC
Acta Clin Belg 2014 Apr;69(2):135-8. doi: 10.1179/0001551213Z.0000000002. PMID: 24724758

Therapy

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report.
Zhang L, Min Q, Bi J, Yu X, Liang Y, Shao M
BMC Womens Health 2023 Mar 23;23(1):119. doi: 10.1186/s12905-023-02285-4. PMID: 36949419Free PMC Article
Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852
Metastatic signet-ring cell carcinoma of unknown primary origin.
Gregoire C, Muller G, Machiels JP, Goeminne JC
Acta Clin Belg 2014 Apr;69(2):135-8. doi: 10.1179/0001551213Z.0000000002. PMID: 24724758
Ovarian malignant Mullerian mixed tumor (heterologous) whose epithelial component is composed predominantly of signet ring cell carcinoma.
Terada T
Arch Gynecol Obstet 2011 Jun;283(6):1403-6. Epub 2010 Jul 23 doi: 10.1007/s00404-010-1591-1. PMID: 20652287
Metastatic foci of signet ring cell carcinoma in a tubular adenoma of the colon.
Bismar TA, Maluf H, Wang HL
Arch Pathol Lab Med 2003 Nov;127(11):1509-12. doi: 10.5858/2003-127-1509-MFOSRC. PMID: 14567750

Prognosis

Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report.
Zhang L, Min Q, Bi J, Yu X, Liang Y, Shao M
BMC Womens Health 2023 Mar 23;23(1):119. doi: 10.1186/s12905-023-02285-4. PMID: 36949419Free PMC Article
Metastatic Signet Ring Cell Carcinoma of the Ampulla of Vater with an Unusually Prolonged Survival.
Javvaji C, Bledsoe JR, Hutchinson L, Cosar EF, McIntosh LJ, Bathini VG
J Gastrointest Cancer 2020 Mar;51(1):354-358. doi: 10.1007/s12029-019-00297-8. PMID: 31456115
Metastatic Signet-Ring Cell Carcinoma of the Skin.
Chrysanthos NV, Nezi V, Zafiropoulou R, Papatheodoridis G, Manesis E
Am J Gastroenterol 2018 Oct;113(10):1427. doi: 10.1038/s41395-018-0099-3. PMID: 29891852
Metastatic Signet-Ring Cell Carcinoma of the Bladder in Cerebrospinal Fluid.
Lin DM, Park JW, Gattuso P
Diagn Cytopathol 2017 Jan;45(1):73-76. Epub 2016 Sep 15 doi: 10.1002/dc.23603. PMID: 27629260
Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach.
Sakashita N, Yokose C, Fujii K, Matsumoto M, Ohnishi K, Takeya M
Pathol Int 2007 Jun;57(6):383-7. doi: 10.1111/j.1440-1827.2007.02111.x. PMID: 17539970

Clinical prediction guides

Fluorescent periodic acid Schiff-like staining combined with standard cytologic staining of the same cytologic specimen may facilitate cytopathologic diagnosis.
Hachisuka D, Nakano S, Takase H, Sugiyama M, Sugiura M, Fujii K, Masaki A, Murase T, Inagaki H
Diagn Cytopathol 2024 Mar;52(3):139-144. Epub 2023 Nov 24 doi: 10.1002/dc.25256. PMID: 37997615
Signet-ring stromal tumor of the testis: a case report and literature review.
Kuo CY, Wen MC, Wang J, Jan YJ
Hum Pathol 2009 Apr;40(4):584-7. Epub 2008 Oct 5 doi: 10.1016/j.humpath.2008.07.012. PMID: 18835626
Signet-ring-cell carcinoma of the prostate. Electron-microscopic and immunohistochemical studies of eight cases.
Ro JY, el-Naggar A, Ayala AG, Mody DR, Ordóñez NG
Am J Surg Pathol 1988 Jun;12(6):453-60. doi: 10.1097/00000478-198806000-00005. PMID: 2454036

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