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Lymphoma, Extranodal NK-T-Cell

MedGen UID:: 364981
•Concept ID:: C1955906
•: Neoplastic Process

Synonyms:

Extranodal NK T Cell Lymphoma; Extranodal NK-T-Cell Lymphoma; Extranodal NK-T-Cell Lymphomas; Lymphoma, Extranodal NK T Cell; Lymphomas, Extranodal NK-T-Cell; NK-T-Cell Lymphoma, Extranodal; NK-T-Cell Lymphomas, Extranodal

Definition

An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLymphoma, Extranodal NK-T-Cell

Neoplasm
- Neoplasm by anatomical site
  - Hematologic neoplasm
    - Lymphoma
      - Non-Hodgkin lymphoma
        T-cell lymphoma
        Lymphoma, Extranodal NK-T-Cell

Professional guidelines

PubMed

Current treatment approaches for NK/T-cell lymphoma.

Yamaguchi M, Miyazaki K
J Clin Exp Hematop 2017 Dec 27;57(3):98-108. Epub 2017 Jul 6 doi: 10.3960/jslrt.17018. PMID: 28679966 Free PMC Article

Disease-oriented treatment of T-cell lymphoma.

Makita S, Tobinai K
Hematol Oncol 2017 Jun;35 Suppl 1:54-59. doi: 10.1002/hon.2401. PMID: 28591416

The diagnosis and management of NK/T-cell lymphomas.

Tse E, Kwong YL
J Hematol Oncol 2017 Apr 14;10(1):85. doi: 10.1186/s13045-017-0452-9. PMID: 28410601 Free PMC Article

See all (64)

Recent clinical studies

Etiology

Extranodal T- and NK-cell lymphomas.

de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765 Free PMC Article

EBV-associated NK and T-cell lymphoid neoplasms.

Kimura H, de Leval L, Cai Q, Kim WS
Curr Opin Oncol 2022 Sep 1;34(5):422-431. Epub 2022 Jul 27 doi: 10.1097/CCO.0000000000000889. PMID: 35900729 Free PMC Article

Efficacy and Safety of a Pegasparaginase-Based Chemotherapy Regimen vs an L-asparaginase-Based Chemotherapy Regimen for Newly Diagnosed Advanced Extranodal Natural Killer/T-Cell Lymphoma: A Randomized Clinical Trial.

Wang X, Zhang L, Liu X, Li X, Li L, Fu X, Sun Z, Wu J, Zhang X, Yan J, Chang Y, Nan F, Zhou Z, Wu X, Tian L, Ma M, Li Z, Yu H, Zhu L, Wang Y, Shi C, Feng X, Li J, Ding M, Zhang J, Dong M, Xue H, Wang J, Zou L, Su L, Wu J, Liu L, Bao H, Zhang L, Guo Y, Guo S, Lu Y, Young KH, Li W, Zhang M
JAMA Oncol 2022 Jul 1;8(7):1035-1041. doi: 10.1001/jamaoncol.2022.1968. PMID: 35708709 Free PMC Article

Modern Radiation Therapy for Extranodal Nasal-Type NK/T-cell Lymphoma: Risk-Adapted Therapy, Target Volume, and Dose Guidelines from the International Lymphoma Radiation Oncology Group.

Qi SN, Li YX, Specht L, Oguchi M, Tsang R, Ng A, Suh CO, Ricardi U, Mac Manus M, Dabaja B, Yahalom J
Int J Radiat Oncol Biol Phys 2021 Jul 15;110(4):1064-1081. Epub 2021 Feb 11 doi: 10.1016/j.ijrobp.2021.02.011. PMID: 33581262

Sinonasal NK/T-cell lymphoma.

Hmidi M, Kettani M, Elboukhari A, Touiheme N, Messary A
Eur Ann Otorhinolaryngol Head Neck Dis 2013 Jun;130(3):145-7. Epub 2012 Dec 28 doi: 10.1016/j.anorl.2012.01.005. PMID: 23273887

See all (468)

Diagnosis

Extranodal T- and NK-cell lymphomas.

de Leval L, Feldman AL, Pileri S, Nakamura S, Gaulard P
Virchows Arch 2023 Jan;482(1):245-264. Epub 2022 Nov 7 doi: 10.1007/s00428-022-03434-0. PMID: 36336765 Free PMC Article

Review on natural killer/T-cell lymphoma.

He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509

How we treat NK/T-cell lymphomas.

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326 Free PMC Article

NK-/T-cell lymphomas.

Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356 Free PMC Article

Extranodal NK/T cell lymphoma, nasal type: An updated overview.

Sánchez-Romero C, Bologna-Molina R, Paes de Almeida O, Santos-Silva AR, Prado-Ribeiro AC, Brandão TB, Carlos R
Crit Rev Oncol Hematol 2021 Mar;159:103237. Epub 2021 Jan 22 doi: 10.1016/j.critrevonc.2021.103237. PMID: 33493634

See all (687)

Therapy

How we treat NK/T-cell lymphomas.

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326 Free PMC Article

Estimating the global burden of Epstein-Barr virus-related cancers.

Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104 Free PMC Article

NK-/T-cell lymphomas.

Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356 Free PMC Article

Modified SMILE (mSMILE) and intensity-modulated radiotherapy (IMRT) for extranodal NK-T lymphoma nasal type in a single-center population.

Ghione P, Qi S, Imber BS, Seshan V, Moskowitz A, Galasso N, Lunning M, Straus D, Sauter C, Dahi P, Dogan A, Yahalom J, Horwitz S
Leuk Lymphoma 2020 Dec;61(14):3331-3341. Epub 2020 Aug 26 doi: 10.1080/10428194.2020.1811864. PMID: 32844695 Free PMC Article

NK/T-cell lymphomas.

Tse E, Kwong YL
Best Pract Res Clin Haematol 2019 Sep;32(3):253-261. Epub 2019 Jun 12 doi: 10.1016/j.beha.2019.06.005. PMID: 31585625

See all (366)

Prognosis

Review on natural killer/T-cell lymphoma.

He X, Gao Y, Li Z, Huang H
Hematol Oncol 2023 Apr;41(2):221-229. Epub 2021 Dec 9 doi: 10.1002/hon.2944. PMID: 34731509

How we treat NK/T-cell lymphomas.

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326 Free PMC Article

NK-/T-cell lymphomas.

Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356 Free PMC Article

Extranodal NK/T cell lymphoma, nasal type: An updated overview.

Management of NK/T-Cell Lymphoma, Nasal Type.

Allen PB, Lechowicz MJ
J Oncol Pract 2019 Oct;15(10):513-520. doi: 10.1200/JOP.18.00719. PMID: 31600461 Free PMC Article

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Clinical prediction guides

How we treat NK/T-cell lymphomas.

Tse E, Zhao WL, Xiong J, Kwong YL
J Hematol Oncol 2022 Jun 3;15(1):74. doi: 10.1186/s13045-022-01293-5. PMID: 35659326 Free PMC Article

Estimating the global burden of Epstein-Barr virus-related cancers.

Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104 Free PMC Article

NK-/T-cell lymphomas.

Wang H, Fu BB, Gale RP, Liang Y
Leukemia 2021 Sep;35(9):2460-2468. Epub 2021 Jun 11 doi: 10.1038/s41375-021-01313-2. PMID: 34117356 Free PMC Article

Extranodal natural killer/T cell lymphoma: we should and we can do more.

Ying Z, Zhu J
Chin Clin Oncol 2015 Mar;4(1):12. doi: 10.3978/j.issn.2304-3865.2015.03.07. PMID: 25841719

Phase II study of SMILE chemotherapy for newly diagnosed stage IV, relapsed, or refractory extranodal natural killer (NK)/T-cell lymphoma, nasal type: the NK-Cell Tumor Study Group study.

Yamaguchi M, Kwong YL, Kim WS, Maeda Y, Hashimoto C, Suh C, Izutsu K, Ishida F, Isobe Y, Sueoka E, Suzumiya J, Kodama T, Kimura H, Hyo R, Nakamura S, Oshimi K, Suzuki R
J Clin Oncol 2011 Nov 20;29(33):4410-6. Epub 2011 Oct 11 doi: 10.1200/JCO.2011.35.6287. PMID: 21990393

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Recent systematic reviews

Allogeneic Hematopoietic Stem Cell Transplantation in Extranodal Natural Killer/T-cell Lymphoma.

Peng YY, Xiong YY, Zhang LX, Wang J, Zhang HB, Xiao Q, Guo SL
Turk J Haematol 2021 Jun 1;38(2):126-137. Epub 2021 Feb 4 doi: 10.4274/tjh.galenos.2021.2020.0438. PMID: 33535731 Free PMC Article

Defining the toxicity of current regimens for extranodal NK/T cell lymphoma: a systematic review and metaproportion.

Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2019 Jan;19(1):93-104. Epub 2018 Nov 23 doi: 10.1080/14737140.2019.1549992. PMID: 30449214

Treatment of localized extranodal NK/T cell lymphoma, nasal type: a systematic review.

Kim SJ, Yoon SE, Kim WS
J Hematol Oncol 2018 Dec 20;11(1):140. doi: 10.1186/s13045-018-0687-0. PMID: 30567593 Free PMC Article

The optimal timing of radiotherapy in the combined modality therapy for limited-stage extranodal NK/T cell lymphoma (ENKTL): a systematic review and meta-analysis.

Hu S, Zhou D, Zhang W
Ann Hematol 2018 Dec;97(12):2279-2287. Epub 2018 Aug 20 doi: 10.1007/s00277-018-3479-2. PMID: 30128904

L-Asparaginase for newly diagnosed extra-nodal NK/T-cell lymphoma: systematic review and meta-analysis.

Pokrovsky VS, Vinnikov D
Expert Rev Anticancer Ther 2017 Aug;17(8):759-768. Epub 2017 Jun 21 doi: 10.1080/14737140.2017.1344100. PMID: 28621166

See all (8)