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Parotid Gland Warthin Tumor

MedGen UID:
365325
•Concept ID:
C1883714
•
Neoplastic Process
Synonyms: Adenolymphoma of parotid gland; Parotid Gland Adenolymphoma; Parotid Gland Papillary Cystadenoma Lymphomatosum; Parotid Gland Warthin's Tumor; Warthin's tumor of parotid gland
SNOMED CT: Adenolymphoma of parotid gland (448211002); Warthin's tumor of parotid gland (448211002)

Definition

An adenoma that arises from the parotid gland. It is characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParotid Gland Warthin Tumor

Professional guidelines

PubMed

Differential diagnosis of parotid gland tumors using apparent diffusion coefficient, texture features, and their combination.
Muraoka H, Kaneda T, Kondo T, Okada S, Tokunaga S
Dentomaxillofac Radiol 2023 Apr;52(4):20220404. Epub 2023 Apr 4 doi: 10.1259/dmfr.20220404. PMID: 37015250Free PMC Article
If cytology of Warthin tumor is accurate, can management be conservative?
Vlantis AC, Ng SK, Mak CK, Cheung JM, Chan AB, van Hasselt CA
Ear Nose Throat J 2016 Apr-May;95(4-5):185-8. PMID: 27140020
Current controversies in the management of Warthin tumour.
Thangarajah T, Reddy VM, Castellanos-Arango F, Panarese A
Postgrad Med J 2009 Jan;85(999):3-8. doi: 10.1136/pgmj.2008.071282. PMID: 19240281

Recent clinical studies

Etiology

Warthin Tumor of the Parotid Gland: The History of an Eponym.
Ide F, Sakamoto S, Miyazaki Y, Nishimura M, Ito Y, Muramatsu T, Kikuchi K
Head Neck Pathol 2023 Sep;17(3):775-781. Epub 2023 May 25 doi: 10.1007/s12105-023-01559-5. PMID: 37227678Free PMC Article
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Sebaceous Lymphadenoma: Radiology-Pathology Correlation.
Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Diagnosis

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928
Outpatient parotidectomy.
Steckler RM
Am J Surg 1991 Oct;162(4):303-5. doi: 10.1016/0002-9610(91)90136-2. PMID: 1659241
Salivary glands.
Saunders JR Jr, Hirata RM, Jaques DA
Surg Clin North Am 1986 Feb;66(1):59-81. doi: 10.1016/s0039-6109(16)43829-6. PMID: 3003940

Therapy

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.
Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Surgical treatment strategy in Warthin tumor of the parotid gland.
Lee DH, Yoon TM, Lee JK, Lim SC
Braz J Otorhinolaryngol 2019 Sep-Oct;85(5):546-550. Epub 2018 May 16 doi: 10.1016/j.bjorl.2018.04.004. PMID: 29807810Free PMC Article
RANK and RANK Ligand Expression in Parotid Gland Carcinomas.
Franchi A, Taverna C, Simoni A, Pepi M, Mannelli G, Fasolati M, Gallo O
Appl Immunohistochem Mol Morphol 2018 Aug;26(7):478-482. doi: 10.1097/PAI.0000000000000465. PMID: 29494398
Functional superficial parotidectomy.
Zhao K, Qi DY, Wang LM
J Oral Maxillofac Surg 1994 Oct;52(10):1038-41. PMID: 8089788

Prognosis

Diffusion-weighted and gadolinium-enhanced dynamic MRI in parotid gland tumors.
Pâris P, Fath L, Schultz P, Veillon F, Riehm S, Severac F, Venkatasamy A
Eur Arch Otorhinolaryngol 2023 Jan;280(1):391-398. Epub 2022 Aug 11 doi: 10.1007/s00405-022-07590-6. PMID: 35951107
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Clinical prediction guides

Diffusion-weighted and gadolinium-enhanced dynamic MRI in parotid gland tumors.
Pâris P, Fath L, Schultz P, Veillon F, Riehm S, Severac F, Venkatasamy A
Eur Arch Otorhinolaryngol 2023 Jan;280(1):391-398. Epub 2022 Aug 11 doi: 10.1007/s00405-022-07590-6. PMID: 35951107
Parotid Warthin's tumor: novel MR imaging score as diagnostic indicator.
Luna LP, Coffey W 3rd, Alvin MD, Shanechi AM, Sankaran N, Rodriguez EF, Naeem Z, Aygun N, Khan M
Clin Imaging 2022 Jan;81:9-14. Epub 2021 Sep 22 doi: 10.1016/j.clinimag.2021.09.005. PMID: 34598007
Classification of parotid gland tumors by using multimodal MRI and deep learning.
Chang YJ, Huang TY, Liu YJ, Chung HW, Juan CJ
NMR Biomed 2021 Jan;34(1):e4408. Epub 2020 Sep 4 doi: 10.1002/nbm.4408. PMID: 32886955Free PMC Article
Recurrent Benign Salivary Gland Neoplasms.
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568
Intraparotid schwannoma.
McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

Recent systematic reviews

Bilateral Warthin's tumour of the parotid gland: a 16-year retrospective analysis and systematic review.
Siddiqui Z, Gupta A, Nam RHK, Huynh RCT, Jan M, Dusu K, Dhar V
J Laryngol Otol 2024 May;138(5):559-564. Epub 2023 Nov 3 doi: 10.1017/S0022215123001834. PMID: 37920099
Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.
Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869Free PMC Article
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368
Warthin's tumor of the larynx: a very rare case and systematic review of the literature.
Nisa L, Landis BN, Salmina C, Ailianou A, Karamitopoulou E, Giger R
J Otolaryngol Head Neck Surg 2015 May 12;44(1):16. doi: 10.1186/s40463-015-0067-5. PMID: 25964051Free PMC Article

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