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Skin squamous cell carcinoma in situ

MedGen UID:
378389
•Concept ID:
C2314897
•
Neoplastic Process
Synonyms: Cancer in situ skin, squamous cell; IEC - Intraepidermal carcinoma of skin; Intraepidermal carcinoma of skin; Intraepidermal Squamous Cell Carcinoma; intraepidermal squamous cell carcinoma; SCC - Squamous cell carcinoma in situ of skin; skin squamous cell cancer in situ; Skin Squamous Cell Carcinoma In Situ; skin squamous cell carcinoma in situ; Squamous cell carcinoma in situ of skin; Squamous Cell Carcinoma in situ of Skin; squamous cell carcinoma in situ of skin; Squamous Cell Carcinoma in situ of the Skin; squamous cell carcinoma in situ of the skin
SNOMED CT: Cancer in situ skin, squamous cell (254656002); IEC - Intraepidermal carcinoma of skin (254656002); SCC - Squamous cell carcinoma in situ of skin (254656002); Intraepidermal carcinoma of skin (254656002); Squamous cell carcinoma in situ of skin (254656002)
 
Monarch Initiative: MONDO:0020760

Definition

Intraepidermal squamous cell carcinoma, confined to the epidermis. There is no evidence of invasion. [from NCI]

Professional guidelines

PubMed

Second Primary Cancers in Patients with Invasive and In Situ Squamous Cell Skin Carcinoma, Kaposi Sarcoma, and Merkel Cell Carcinoma: Role for Immune Mechanisms?
Chattopadhyay S, Hemminki A, Försti A, Sundquist K, Sundquist J, Hemminki K
J Invest Dermatol 2020 Jan;140(1):48-55.e1. Epub 2019 Jul 6 doi: 10.1016/j.jid.2019.04.031. PMID: 31288011

Recent clinical studies

Etiology

Invasive and in situ squamous cell carcinoma of the skin: a nationwide study in Iceland.
Adalsteinsson JA, Olafsdottir E, Ratner D, Waldman R, Feng H, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L
Br J Dermatol 2021 Sep;185(3):537-547. Epub 2021 May 9 doi: 10.1111/bjd.19879. PMID: 33609287
Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

Diagnosis

Basal Cell and Cutaneous Squamous Cell Carcinomas: Diagnosis and Treatment.
Firnhaber JM
Am Fam Physician 2020 Sep 15;102(6):339-346. PMID: 32931212
Dermatoscopy of Neoplastic Skin Lesions: Recent Advances, Updates, and Revisions.
Weber P, Tschandl P, Sinz C, Kittler H
Curr Treat Options Oncol 2018 Sep 20;19(11):56. doi: 10.1007/s11864-018-0573-6. PMID: 30238167Free PMC Article
Bowen's Disease in Dermoscopy.
Wozniak-Rito AM, Rudnicka L
Acta Dermatovenerol Croat 2018 Jun;26(2):157-161. PMID: 29989873
Differential diagnosis of squamous cell carcinoma in situ using skin histopathological images.
Noroozi N, Zakerolhosseini A
Comput Biol Med 2016 Mar 1;70:23-39. Epub 2016 Jan 7 doi: 10.1016/j.compbiomed.2015.12.024. PMID: 26780250
Psoriasin (S100A7).
Watson PH, Leygue ER, Murphy LC
Int J Biochem Cell Biol 1998 May;30(5):567-71. doi: 10.1016/s1357-2725(97)00066-6. PMID: 9693957

Therapy

Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update.
O'Connell KA, Okhovat JP, Zeitouni NC
Photodiagnosis Photodyn Ther 2018 Dec;24:109-114. Epub 2018 Sep 18 doi: 10.1016/j.pdpdt.2018.09.009. PMID: 30240928
Factors Influencing Squamous Cell Carcinoma In Situ Recurrence and Implications for Treatment Choice.
Matsumoto AJ, Schmitt AR, Skelley LM, Baum CL
Dermatol Surg 2018 May;44(5):613-620. doi: 10.1097/DSS.0000000000001400. PMID: 29112529
Precancerous Skin Lesions.
Ferrándiz C, Malvehy J, Guillén C, Ferrándiz-Pulido C, Fernández-Figueras M
Actas Dermosifiliogr 2017 Jan-Feb;108(1):31-41. Epub 2016 Sep 20 doi: 10.1016/j.ad.2016.07.016. PMID: 27658688
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

Prognosis

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Morphologic Diversity of Merkel Cell Carcinoma.
Ogawa T, Donizy P, Wu CL, Cornejo KM, Ryś J, Hoang MP
Am J Dermatopathol 2020 Sep;42(9):629-640. doi: 10.1097/DAD.0000000000001548. PMID: 32833736
Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.
Ventura A, Pellegrini C, Cardelli L, Rocco T, Ciciarelli V, Peris K, Fargnoli MC
Int J Mol Sci 2019 Mar 16;20(6) doi: 10.3390/ijms20061333. PMID: 30884806Free PMC Article
Lichen sclerosus.
Murphy R
Dermatol Clin 2010 Oct;28(4):707-15. doi: 10.1016/j.det.2010.07.006. PMID: 20883914

Clinical prediction guides

Telomeres and Telomerase in Cutaneous Squamous Cell Carcinoma.
Ventura A, Pellegrini C, Cardelli L, Rocco T, Ciciarelli V, Peris K, Fargnoli MC
Int J Mol Sci 2019 Mar 16;20(6) doi: 10.3390/ijms20061333. PMID: 30884806Free PMC Article
Actinic keratosis and squamous cell carcinoma: clinical and pathological features.
Filosa A, Filosa G
G Ital Dermatol Venereol 2015 Aug;150(4):379-84. Epub 2015 Jun 23 PMID: 26099352
Noninfectious penile lesions.
Teichman JM, Sea J, Thompson IM, Elston DM
Am Fam Physician 2010 Jan 15;81(2):167-74. PMID: 20082512
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624
Arsenic-induced skin toxicity.
Shannon RL, Strayer DS
Hum Toxicol 1989 Mar;8(2):99-104. doi: 10.1177/096032718900800203. PMID: 2663702

Recent systematic reviews

Evidence-Based Clinical Practice Guidelines for Laser-Assisted Drug Delivery.
Labadie JG, Ibrahim SA, Worley B, Kang BY, Rakita U, Rigali S, Arndt KA, Bernstein E, Brauer JA, Chandra S, Didwania A, DiGiorgio C, Donelan M, Dover JS, Galadari H, Geronemus RG, Goldman MP, Haedersdal M, Hruza G, Ibrahimi OA, Kauvar A, Kelly KM, Krakowski AC, Miest R, Orringer JS, Ozog DM, Ross EV, Shumaker PR, Sobanko JF, Suozzi K, Taylor MB, Teng JMC, Uebelhoer NS, Waibel J, Wanner M, Ratchev I, Christensen RE, Poon E, Miller CH, Alam M
JAMA Dermatol 2022 Oct 1;158(10):1193-1201. doi: 10.1001/jamadermatol.2022.3234. PMID: 35976634
Treatment Options and Outcomes for Squamous Cell Carcinoma of the Nail Unit: A Systematic Review.
Ning AY, Levoska MA, Zheng DX, Carroll BT, Wong CY
Dermatol Surg 2022 Mar 1;48(3):267-273. doi: 10.1097/DSS.0000000000003319. PMID: 34889218
Efficacy of nonexcisional treatment modalities for superficially invasive and in situ squamous cell carcinoma: A systematic review and meta-analysis.
Stewart JR, Lang ME, Brewer JD
J Am Acad Dermatol 2022 Jul;87(1):131-137. Epub 2021 Aug 8 doi: 10.1016/j.jaad.2021.07.067. PMID: 34375669
Photodynamic therapy and pain: A systematic review.
Ang JM, Riaz IB, Kamal MU, Paragh G, Zeitouni NC
Photodiagnosis Photodyn Ther 2017 Sep;19:308-344. Epub 2017 Jul 15 doi: 10.1016/j.pdpdt.2017.07.002. PMID: 28716738
Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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