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Cervical Glandular Intraepithelial Neoplasia

MedGen UID:
384477
•Concept ID:
C2044987
•
Neoplastic Process

Definition

A neoplastic process that affects the glandular epithelial cells of the cervix. There is no evidence of invasion. It is classified as low or high grade. [from NCI]

Professional guidelines

PubMed

Improved national Croatian diagnostic and therapeutic guidelines for premalignant lesions of the uterine cervix with some cost-benefit aspects.
Ljubojević N, Babić S, Audy-Jurković S, Ovanin-Rakić A, Jukić S, Babić D, Grubisić G, Radaković B, Ljubojević-Grgec D
Coll Antropol 2001 Dec;25(2):467-74. PMID: 11811276

Recent clinical studies

Etiology

Are we managing our patients correctly following treatment for cervical glandular intraepithelial neoplasia? A review of practice at the Jessop Wing Colposcopy Unit.
Magro A, Lyon R, Ellis KM, Tidy JA, Macdonald MC, Palmer JE
Cytopathology 2021 Nov;32(6):758-765. Epub 2021 Sep 5 doi: 10.1111/cyt.13044. PMID: 34331788
Cervical glandular neoplasia referrals and the diagnosis of adenocarcinoma in situ: Correlating cytology, colposcopy findings, and clinical outcomes.
Nikolopoulos M, Athanasias P, Godfrey MAL, Nikolopoulos K, Maheshwari MK
Cytopathology 2021 Nov;32(6):751-757. Epub 2021 Jul 20 doi: 10.1111/cyt.13027. PMID: 34181788
Study of clinical diagnosis of cervical glandular intraepithelial neoplasia.
Yang S, Duan W, Kong W, Zhu L, Wu Y
Eur J Gynaecol Oncol 2016 Aug;37(4):539-542. PMID: 29894080
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
Aetiology, pathogenesis, and pathology of cervical neoplasia.
Arends MJ, Buckley CH, Wells M
J Clin Pathol 1998 Feb;51(2):96-103. doi: 10.1136/jcp.51.2.96. PMID: 9602680Free PMC Article

Diagnosis

Are we managing our patients correctly following treatment for cervical glandular intraepithelial neoplasia? A review of practice at the Jessop Wing Colposcopy Unit.
Magro A, Lyon R, Ellis KM, Tidy JA, Macdonald MC, Palmer JE
Cytopathology 2021 Nov;32(6):758-765. Epub 2021 Sep 5 doi: 10.1111/cyt.13044. PMID: 34331788
Cervical glandular neoplasia referrals and the diagnosis of adenocarcinoma in situ: Correlating cytology, colposcopy findings, and clinical outcomes.
Nikolopoulos M, Athanasias P, Godfrey MAL, Nikolopoulos K, Maheshwari MK
Cytopathology 2021 Nov;32(6):751-757. Epub 2021 Jul 20 doi: 10.1111/cyt.13027. PMID: 34181788
Study of clinical diagnosis of cervical glandular intraepithelial neoplasia.
Yang S, Duan W, Kong W, Zhu L, Wu Y
Eur J Gynaecol Oncol 2016 Aug;37(4):539-542. PMID: 29894080
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
The pathology and management of endocervical glandular neoplasia.
El-Ghobashy AA, Shaaban AM, Herod J, Herrington CS
Int J Gynecol Cancer 2005 Jul-Aug;15(4):583-92. doi: 10.1111/j.1525-1438.2005.00113.x. PMID: 16014110

Prognosis

New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447
The role of cervical cytology and colposcopy in detecting cervical glandular neoplasia.
Ullal A, Roberts M, Bulmer JN, Mathers ME, Wadehra V
Cytopathology 2009 Dec;20(6):359-66. Epub 2008 Jun 28 doi: 10.1111/j.1365-2303.2008.00566.x. PMID: 18557985
The pathology and management of endocervical glandular neoplasia.
El-Ghobashy AA, Shaaban AM, Herod J, Herrington CS
Int J Gynecol Cancer 2005 Jul-Aug;15(4):583-92. doi: 10.1111/j.1525-1438.2005.00113.x. PMID: 16014110
p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ
J Clin Pathol 2005 May;58(5):525-34. doi: 10.1136/jcp.2004.018895. PMID: 15858126Free PMC Article
The expression of epithelial specific antigen in cervical intraepithelial neoplasia and adenocarcinoma.
Markaki S, Lazaris D, Papaspirou I, Paulou V
Eur J Gynaecol Oncol 2004;25(1):101-3. PMID: 15053074

Clinical prediction guides

MYBL2 (B-MYB) in cervical cancer: putative biomarker.
Astbury K, McEvoy L, Brian H, Spillane C, Sheils O, Martin C, O'Leary JJ
Int J Gynecol Cancer 2011 Feb;21(2):206-12. doi: 10.1097/IGC.0b013e318205759f. PMID: 21270603
The role of cervical cytology and colposcopy in detecting cervical glandular neoplasia.
Ullal A, Roberts M, Bulmer JN, Mathers ME, Wadehra V
Cytopathology 2009 Dec;20(6):359-66. Epub 2008 Jun 28 doi: 10.1111/j.1365-2303.2008.00566.x. PMID: 18557985
p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer.
Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ
J Clin Pathol 2005 May;58(5):525-34. doi: 10.1136/jcp.2004.018895. PMID: 15858126Free PMC Article
The expression of epithelial specific antigen in cervical intraepithelial neoplasia and adenocarcinoma.
Markaki S, Lazaris D, Papaspirou I, Paulou V
Eur J Gynaecol Oncol 2004;25(1):101-3. PMID: 15053074
A clinical review of borderline glandular cells on cervical cytology.
Mohammed DK, Lavie O, de B Lopes A, Cross P, Monaghan JM
BJOG 2000 May;107(5):605-9. doi: 10.1111/j.1471-0528.2000.tb13300.x. PMID: 10826573

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