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Increased cardiac output

MedGen UID:
38798
•Concept ID:
C0085128
•
Finding
Synonyms: Cardiac Output, High; Cardiac Outputs, High; High Cardiac Output; High Cardiac Outputs
SNOMED CT: Increased cardiac output (27545003)
 
HPO: HP:0033533

Definition

An increased volume of blood pumped by the left and right ventricle, per unit time. Cardiac output (CO) is the product of the heart rate (HR), i.e. the number of heartbeats per minute (bpm), and the stroke volume (SV), which is the volume of blood pumped from the ventricle per beat. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased cardiac output

Professional guidelines

PubMed

Shock Etiologies and Fluid Management in Liver Failure.
Weiss E, Paugam-Burtz C, Jaber S
Semin Respir Crit Care Med 2018 Oct;39(5):538-545. Epub 2018 Nov 28 doi: 10.1055/s-0038-1672139. PMID: 30485884
Diagnosing and treating neurogenic orthostatic hypotension in primary care.
Kuritzky L, Espay AJ, Gelblum J, Payne R, Dietrich E
Postgrad Med 2015;127(7):702-15. Epub 2015 May 27 doi: 10.1080/00325481.2015.1050340. PMID: 26012731
Impedance Cardiography-Guided Treatment of Hypertension: A Review of the Literature.
Khraim F, Pike R
Can J Cardiovasc Nurs 2014 Fall;24(4):7-12. PMID: 27356462

Recent clinical studies

Etiology

Hypertension and Hyperthyroidism: Association and Pathogenesis.
Rivas AM, Pena C, Kopel J, Dennis JA, Nugent K
Am J Med Sci 2021 Jan;361(1):3-7. Epub 2020 Aug 10 doi: 10.1016/j.amjms.2020.08.012. PMID: 33012487
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis.
Solomon SD, Adams D, Kristen A, Grogan M, González-Duarte A, Maurer MS, Merlini G, Damy T, Slama MS, Brannagan TH 3rd, Dispenzieri A, Berk JL, Shah AM, Garg P, Vaishnaw A, Karsten V, Chen J, Gollob J, Vest J, Suhr O
Circulation 2019 Jan 22;139(4):431-443. doi: 10.1161/CIRCULATIONAHA.118.035831. PMID: 30586695
Novel Paradigms of Salt and Hypertension.
Feng W, Dell'Italia LJ, Sanders PW
J Am Soc Nephrol 2017 May;28(5):1362-1369. Epub 2017 Feb 20 doi: 10.1681/ASN.2016080927. PMID: 28220030Free PMC Article
High-Output Heart Failure: A 15-Year Experience.
Reddy YNV, Melenovsky V, Redfield MM, Nishimura RA, Borlaug BA
J Am Coll Cardiol 2016 Aug 2;68(5):473-482. doi: 10.1016/j.jacc.2016.05.043. PMID: 27470455
Cirrhotic cardiomyopathy: a cardiologist's perspective.
Gassanov N, Caglayan E, Semmo N, Massenkeil G, Er F
World J Gastroenterol 2014 Nov 14;20(42):15492-8. doi: 10.3748/wjg.v20.i42.15492. PMID: 25400434Free PMC Article

Diagnosis

Obstructive Sleep Apnea and Cardiovascular Disease.
Diamond JA, Ismail H
Clin Geriatr Med 2021 Aug;37(3):445-456. Epub 2021 Jun 5 doi: 10.1016/j.cger.2021.04.006. PMID: 34210449
Hypertension and Hyperthyroidism: Association and Pathogenesis.
Rivas AM, Pena C, Kopel J, Dennis JA, Nugent K
Am J Med Sci 2021 Jan;361(1):3-7. Epub 2020 Aug 10 doi: 10.1016/j.amjms.2020.08.012. PMID: 33012487
High-Output Heart Failure: A 15-Year Experience.
Reddy YNV, Melenovsky V, Redfield MM, Nishimura RA, Borlaug BA
J Am Coll Cardiol 2016 Aug 2;68(5):473-482. doi: 10.1016/j.jacc.2016.05.043. PMID: 27470455
Cirrhotic cardiomyopathy.
Møller S, Henriksen JH
J Hepatol 2010 Jul;53(1):179-90. Epub 2010 Mar 31 doi: 10.1016/j.jhep.2010.02.023. PMID: 20462649
Levosimendan.
Figgitt DP, Gillies PS, Goa KL
Drugs 2001;61(5):613-27; discussion 628-9. doi: 10.2165/00003495-200161050-00006. PMID: 11368286

Therapy

Obstructive Sleep Apnea and Cardiovascular Disease.
Diamond JA, Ismail H
Clin Geriatr Med 2021 Aug;37(3):445-456. Epub 2021 Jun 5 doi: 10.1016/j.cger.2021.04.006. PMID: 34210449
Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity.
Baldo BA
Arch Toxicol 2021 Aug;95(8):2627-2642. Epub 2021 May 11 doi: 10.1007/s00204-021-03068-2. PMID: 33974096
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis.
Solomon SD, Adams D, Kristen A, Grogan M, González-Duarte A, Maurer MS, Merlini G, Damy T, Slama MS, Brannagan TH 3rd, Dispenzieri A, Berk JL, Shah AM, Garg P, Vaishnaw A, Karsten V, Chen J, Gollob J, Vest J, Suhr O
Circulation 2019 Jan 22;139(4):431-443. doi: 10.1161/CIRCULATIONAHA.118.035831. PMID: 30586695
Comparison of exercise intensity during four early rehabilitation techniques in sedated and ventilated patients in ICU: a randomised cross-over trial.
Medrinal C, Combret Y, Prieur G, Robledo Quesada A, Bonnevie T, Gravier FE, Dupuis Lozeron E, Frenoy E, Contal O, Lamia B
Crit Care 2018 Apr 27;22(1):110. doi: 10.1186/s13054-018-2030-0. PMID: 29703223Free PMC Article
Levosimendan.
Figgitt DP, Gillies PS, Goa KL
Drugs 2001;61(5):613-27; discussion 628-9. doi: 10.2165/00003495-200161050-00006. PMID: 11368286

Prognosis

Cardiac Morphology, Function, and Hemodynamics in Patients With Morbid Obesity and Nonalcoholic Steatohepatitis.
Styczynski G, Kalinowski P, Michałowski Ł, Paluszkiewicz R, Ziarkiewicz-Wróblewska B, Zieniewicz K, Tataj E, Rabczenko D, Szmigielski CA, Sinski M
J Am Heart Assoc 2021 Apr 20;10(8):e017371. Epub 2021 Apr 13 doi: 10.1161/JAHA.120.017371. PMID: 33847141Free PMC Article
High-Output Heart Failure: A 15-Year Experience.
Reddy YNV, Melenovsky V, Redfield MM, Nishimura RA, Borlaug BA
J Am Coll Cardiol 2016 Aug 2;68(5):473-482. doi: 10.1016/j.jacc.2016.05.043. PMID: 27470455
Impact of obesity and weight loss on cardiac performance and morphology in adults.
Alpert MA, Omran J, Mehra A, Ardhanari S
Prog Cardiovasc Dis 2014 Jan-Feb;56(4):391-400. Epub 2013 Oct 26 doi: 10.1016/j.pcad.2013.09.003. PMID: 24438730
Cirrhotic cardiomyopathy.
Baik SK, Fouad TR, Lee SS
Orphanet J Rare Dis 2007 Mar 27;2:15. doi: 10.1186/1750-1172-2-15. PMID: 17389039Free PMC Article
Hydralazine in heart failure.
Chatterjee K
Herz 1983 Aug;8(4):187-98. PMID: 6413340

Clinical prediction guides

Translational Sciences in Cardiac Failure Secondary to Arteriovenous Fistula in Hemodialysis Patients.
Zahra SA, Choudhury RY, Basharat K, Tran T, Begum M, Abotabekh A, Hedayat F, Rimmer L, Harky A, Bashir M
Ann Vasc Surg 2021 Jul;74:431-449. Epub 2021 Feb 6 doi: 10.1016/j.avsg.2021.01.071. PMID: 33556504
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis.
Solomon SD, Adams D, Kristen A, Grogan M, González-Duarte A, Maurer MS, Merlini G, Damy T, Slama MS, Brannagan TH 3rd, Dispenzieri A, Berk JL, Shah AM, Garg P, Vaishnaw A, Karsten V, Chen J, Gollob J, Vest J, Suhr O
Circulation 2019 Jan 22;139(4):431-443. doi: 10.1161/CIRCULATIONAHA.118.035831. PMID: 30586695
Cirrhotic cardiomyopathy: a cardiologist's perspective.
Gassanov N, Caglayan E, Semmo N, Massenkeil G, Er F
World J Gastroenterol 2014 Nov 14;20(42):15492-8. doi: 10.3748/wjg.v20.i42.15492. PMID: 25400434Free PMC Article
Cirrhotic cardiomyopathy.
Møller S, Henriksen JH
J Hepatol 2010 Jul;53(1):179-90. Epub 2010 Mar 31 doi: 10.1016/j.jhep.2010.02.023. PMID: 20462649
Cardiac dysfunction in cirrhosis.
Lee RF, Glenn TK, Lee SS
Best Pract Res Clin Gastroenterol 2007;21(1):125-40. doi: 10.1016/j.bpg.2006.06.003. PMID: 17223501

Recent systematic reviews

Efficacy and safety of iloprost in the treatment of pulmonary arterial hypertension: A systematic review and meta-analysis.
Zhou R, Zhao Z, Liu J, Liu M, Xie F
Heart Lung 2024 Mar-Apr;64:36-45. Epub 2023 Nov 22 doi: 10.1016/j.hrtlng.2023.11.006. PMID: 37992575
Pulmonary Artery Denervation as a New Therapeutic Option for Pulmonary Hypertension: A Systematic Review and Meta-Analysis.
Salazar AM, Al-Asad KS, Prasad RM, Panama G, Banga S, Wilcox M
Curr Probl Cardiol 2023 Sep;48(9):101776. Epub 2023 Apr 29 doi: 10.1016/j.cpcardiol.2023.101776. PMID: 37121454
Glucagon in beta-blocker and calcium channel blocker overdoses: a systematic review.
Bailey B
J Toxicol Clin Toxicol 2003;41(5):595-602. doi: 10.1081/clt-120023761. PMID: 14514004

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