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Bronchial hyperreactivity

MedGen UID:
38799
•Concept ID:
C0085129
•
Disease or Syndrome
Synonyms: Bronchial Hyperreactivities; Bronchial Hyperreactivity; Hyperreactivities, Bronchial; Hyperreactivity, Bronchial
SNOMED CT: Bronchial hyperreactivity (195967001); BHR - Bronchial hyperreactivity (195967001); Bronchial hyperresponsiveness (195967001); Bronchial hypersensitivity (195967001)

Definition

Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBronchial hyperreactivity

Professional guidelines

PubMed

Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Persson EK, Verstraete K, Heyndrickx I, Gevaert E, Aegerter H, Percier JM, Deswarte K, Verschueren KHG, Dansercoer A, Gras D, Chanez P, Bachert C, Gonçalves A, Van Gorp H, De Haard H, Blanchetot C, Saunders M, Hammad H, Savvides SN, Lambrecht BN
Science 2019 May 24;364(6442) doi: 10.1126/science.aaw4295. PMID: 31123109
The role of hyaluronan in the pathobiology and treatment of respiratory disease.
Garantziotis S, Brezina M, Castelnuovo P, Drago L
Am J Physiol Lung Cell Mol Physiol 2016 May 1;310(9):L785-95. Epub 2016 Jan 8 doi: 10.1152/ajplung.00168.2015. PMID: 26747781Free PMC Article
Primary Care of the Patient with Asthma.
Lenaeus MJ, Hirschmann J
Med Clin North Am 2015 Sep;99(5):953-67. doi: 10.1016/j.mcna.2015.05.007. PMID: 26320041

Recent clinical studies

Etiology

Intermittent hypoxia and bronchial hyperreactivity.
Raffay TM, Martin RJ
Semin Fetal Neonatal Med 2020 Apr;25(2):101073. Epub 2019 Dec 9 doi: 10.1016/j.siny.2019.101073. PMID: 31862223Free PMC Article
Asthma in Olympians.
Carlsen KH
Paediatr Respir Rev 2016 Jan;17:34-5. Epub 2015 Nov 27 doi: 10.1016/j.prrv.2015.08.013. PMID: 26631837
What is asthma? Pathophysiology, demographics, and health care costs.
Maslan J, Mims JW
Otolaryngol Clin North Am 2014 Feb;47(1):13-22. Epub 2013 Nov 1 doi: 10.1016/j.otc.2013.09.010. PMID: 24286675
Understanding asthma pathophysiology.
Fireman P
Allergy Asthma Proc 2003 Mar-Apr;24(2):79-83. PMID: 12776439
Asthmatic bronchitis.
Griffith DE, Garcia JG
Semin Respir Infect 1988 Mar;3(1):27-39. PMID: 3283880

Diagnosis

Intermittent hypoxia and bronchial hyperreactivity.
Raffay TM, Martin RJ
Semin Fetal Neonatal Med 2020 Apr;25(2):101073. Epub 2019 Dec 9 doi: 10.1016/j.siny.2019.101073. PMID: 31862223Free PMC Article
What is the role of bronchial thermoplasty in the management of severe asthma?
O'Reilly A, Lane S
Ther Adv Respir Dis 2018 Jan-Dec;12:1753466618792410. doi: 10.1177/1753466618792410. PMID: 30132377Free PMC Article
Bronchial hyper-responsiveness after preterm birth.
Clemm HH, Engeseth M, Vollsæter M, Kotecha S, Halvorsen T
Paediatr Respir Rev 2018 Mar;26:34-40. Epub 2017 Jun 20 doi: 10.1016/j.prrv.2017.06.010. PMID: 28709779
Asthma.
Virchow JC, Barnes PJ
Semin Respir Crit Care Med 2012 Dec;33(6):577. Epub 2012 Oct 9 doi: 10.1055/s-0032-1326958. PMID: 23047308
Bronchoprovocation testing in asthma.
Katial RK, Covar RA
Immunol Allergy Clin North Am 2012 Aug;32(3):413-31. Epub 2012 Jul 20 doi: 10.1016/j.iac.2012.06.002. PMID: 22877619

Therapy

Bronchial thermoplasty: interventional therapy in asthma.
Kaukel P, Herth FJ, Schuhmann M
Ther Adv Respir Dis 2014 Feb;8(1):22-9. Epub 2013 Dec 10 doi: 10.1177/1753465813509302. PMID: 24334336
Role of interleukin-13 in asthma.
Corren J
Curr Allergy Asthma Rep 2013 Oct;13(5):415-20. doi: 10.1007/s11882-013-0373-9. PMID: 24026573
Bronchial provocation testing: the future.
Anderson SD, Brannan JD
Curr Opin Allergy Clin Immunol 2011 Feb;11(1):46-52. doi: 10.1097/ACI.0b013e3283423183. PMID: 21150437
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
Reddel HK, Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, de Jongste JC, Kerstjens HA, Lazarus SC, Levy ML, O'Byrne PM, Partridge MR, Pavord ID, Sears MR, Sterk PJ, Stoloff SW, Sullivan SD, Szefler SJ, Thomas MD, Wenzel SE; American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations
Am J Respir Crit Care Med 2009 Jul 1;180(1):59-99. doi: 10.1164/rccm.200801-060ST. PMID: 19535666
The beta-agonist saga and its clinical relevance: on and on it goes.
Taylor DR
Am J Respir Crit Care Med 2009 Jun 1;179(11):976-8. Epub 2009 Mar 12 doi: 10.1164/rccm.200901-0055CC. PMID: 19286624

Prognosis

Intermittent hypoxia and bronchial hyperreactivity.
Raffay TM, Martin RJ
Semin Fetal Neonatal Med 2020 Apr;25(2):101073. Epub 2019 Dec 9 doi: 10.1016/j.siny.2019.101073. PMID: 31862223Free PMC Article
Subclinical lower airways correlates of chronic allergic and non-allergic rhinitis.
Saranz RJ, Lozano A, Lozano NA, Ponzio MF, Cruz ÁA
Clin Exp Allergy 2017 Aug;47(8):988-997. Epub 2017 May 17 doi: 10.1111/cea.12938. PMID: 28421631
Introduction to asthma and phenotyping.
Pillai RA, Calhoun WJ
Adv Exp Med Biol 2014;795:5-15. doi: 10.1007/978-1-4614-8603-9_1. PMID: 24162899
Asthma in the elderly.
Braman SS
Clin Geriatr Med 2003 Feb;19(1):57-75. doi: 10.1016/s0749-0690(02)00052-6. PMID: 12735115
Bronchial hyperreactivity revisited.
Smith L, McFadden ER Jr
Ann Allergy Asthma Immunol 1995 Jun;74(6):454-69, quiz 469-70. PMID: 7788511

Clinical prediction guides

Intermittent hypoxia and bronchial hyperreactivity.
Raffay TM, Martin RJ
Semin Fetal Neonatal Med 2020 Apr;25(2):101073. Epub 2019 Dec 9 doi: 10.1016/j.siny.2019.101073. PMID: 31862223Free PMC Article
Subclinical lower airways correlates of chronic allergic and non-allergic rhinitis.
Saranz RJ, Lozano A, Lozano NA, Ponzio MF, Cruz ÁA
Clin Exp Allergy 2017 Aug;47(8):988-997. Epub 2017 May 17 doi: 10.1111/cea.12938. PMID: 28421631
Introduction to asthma and phenotyping.
Pillai RA, Calhoun WJ
Adv Exp Med Biol 2014;795:5-15. doi: 10.1007/978-1-4614-8603-9_1. PMID: 24162899
Wheezes.
Meslier N, Charbonneau G, Racineux JL
Eur Respir J 1995 Nov;8(11):1942-8. doi: 10.1183/09031936.95.08111942. PMID: 8620967
Asthmatic bronchitis.
Griffith DE, Garcia JG
Semin Respir Infect 1988 Mar;3(1):27-39. PMID: 3283880

Recent systematic reviews

Helminth infections and allergic diseases: Systematic review and meta-analysis of the global literature.
Arrais M, Maricoto T, Nwaru BI, Cooper PJ, Gama JMR, Brito M, Taborda-Barata L
J Allergy Clin Immunol 2022 Jun;149(6):2139-2152. Epub 2021 Dec 28 doi: 10.1016/j.jaci.2021.12.777. PMID: 34968529
Asthma, bronchial hyperresponsiveness, allergy and lung function development until early adulthood: A systematic literature review.
Koefoed HJL, Zwitserloot AM, Vonk JM, Koppelman GH
Pediatr Allergy Immunol 2021 Aug;32(6):1238-1254. Epub 2021 May 13 doi: 10.1111/pai.13516. PMID: 33835532Free PMC Article
WITHDRAWN: Inhaled bronchodilators for cystic fibrosis.
Halfhide C, Evans HJ, Couriel J
Cochrane Database Syst Rev 2016 Feb 11;2(2):CD003428. doi: 10.1002/14651858.CD003428.pub3. PMID: 26866910Free PMC Article
Bronchial hyperresponsiveness.
Borak J, Lefkowitz RY
Occup Med (Lond) 2016 Mar;66(2):95-105. Epub 2015 Nov 20 doi: 10.1093/occmed/kqv158. PMID: 26590957
The relationship between asthma and suicidal behaviours: a systematic literature review.
Barker E, Kõlves K, De Leo D
Eur Respir J 2015 Jul;46(1):96-106. Epub 2015 Apr 2 doi: 10.1183/09031936.00011415. PMID: 25837034

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