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Pulmonary plasma cell granuloma

MedGen UID:
38832
•Concept ID:
C0085269
•
Neoplastic Process
Synonyms: Granuloma, Plasma Cell, Pulmonary; Inflammatory Pseudotumor of Lung; Inflammatory Pseudotumor, Pulmonary; Inflammatory Pseudotumors, Pulmonary; Inflammatory Pulmonary Pseudotumor; Inflammatory Pulmonary Pseudotumors; Plasma Cell Granuloma of Lung; Plasma Cell Granuloma, Pulmonary; Pseudotumor, Inflammatory, Pulmonary; Pseudotumor, Pulmonary Inflammatory; Pulmonary Granuloma, Plasma Cell; Pulmonary Inflammatory Pseudotumor; Pulmonary Inflammatory Pseudotumors; Pulmonary Plasma Cell Granuloma; Pulmonary Pseudotumor, Inflammatory; Pulmonary Pseudotumors, Inflammatory
SNOMED CT: Plasma cell granuloma of lung (707373004); Pulmonary plasma cell granuloma (707373004); Histiocytoma of lung (254641006); Sclerosing hemangiocytoma of lung (254641006); Lymphocytic pseudotumor of lung (1648002); Inflammatory pseudotumor of lung (1648002)
 
Monarch Initiative: MONDO:0006933

Definition

Tumour-like mass in lungs composed of fibrous tissue or granulation tissue with inflammatory cells. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary plasma cell granuloma

Professional guidelines

PubMed

Inflammatory pseudotumor and myofibroblastic inflammatory tumor. Diagnostic criteria and prognostic differences.
Carrasco Rodríguez R, García Fontán EM, Blanco Ramos M, Magdalena Benavides LJ, Otero Lozano D, Moldes Rodriguez M, Cañizares Carretero MA
Cir Esp (Engl Ed) 2022 Jun;100(6):329-335. Epub 2022 May 13 doi: 10.1016/j.cireng.2022.05.012. PMID: 35577280
Inflammatory myofibroblastic tumor in children: diagnosis and treatment.
Karnak I, Senocak ME, Ciftci AO, Cağlar M, Bingöl-Koloğlu M, Tanyel FC, Büyükpamukçu N
J Pediatr Surg 2001 Jun;36(6):908-12. doi: 10.1053/jpsu.2001.23970. PMID: 11381424
Wegener's granulomatosis, lymphomatoid granulomatosis, and benign lymphocytic angiitis and granulomatosis of lung. Recognition and treatment.
Israel HL, Patchefsky AS, Saldana MJ
Ann Intern Med 1977 Dec;87(6):691-9. doi: 10.7326/0003-4819-87-6-691. PMID: 931205

Recent clinical studies

Etiology

Clinical and Histopathologic Correlates and Management Strategies for Inflammatory Myofibroblastic tumor of the lung. A case series and review of the literature.
Sagar AES, Jimenez CA, Shannon VR
Med Oncol 2018 Jun 4;35(7):102. doi: 10.1007/s12032-018-1161-0. PMID: 29869302
Plasma cell granuloma involving the brain and the lung.
Greiner C, Rickert CH, Möllmann FT, Rieger B, Semik M, Heindel W, Wassmann H
Acta Neurochir (Wien) 2003 Dec;145(12):1127-31. Epub 2003 Sep 22 doi: 10.1007/s00701-003-0109-z. PMID: 14663572
Plasma cell granuloma of the lung: difficulties in diagnosis and prognosis.
Copin MC, Gosselin BH, Ribet ME
Ann Thorac Surg 1996 May;61(5):1477-82. doi: 10.1016/0003-4975(96)00081-1. PMID: 8633962
Childhood primary pulmonary neoplasms.
Hancock BJ, Di Lorenzo M, Youssef S, Yazbeck S, Marcotte JE, Collin PP
J Pediatr Surg 1993 Sep;28(9):1133-6. doi: 10.1016/0022-3468(93)90147-d. PMID: 8308677
Plasma cell granuloma of the lung.
Urschel JD, Horan TA, Unruh HW
J Thorac Cardiovasc Surg 1992 Oct;104(4):870-5. PMID: 1405683

Diagnosis

IgG4-positive plasma cells in inflammatory pseudotumor (plasma cell granuloma) of the lung.
Zen Y, Kitagawa S, Minato H, Kurumaya H, Katayanagi K, Masuda S, Niwa H, Fujimura M, Nakanuma Y
Hum Pathol 2005 Jul;36(7):710-7. doi: 10.1016/j.humpath.2005.05.011. PMID: 16084938
Plasma cell granuloma of the lung: difficulties in diagnosis and prognosis.
Copin MC, Gosselin BH, Ribet ME
Ann Thorac Surg 1996 May;61(5):1477-82. doi: 10.1016/0003-4975(96)00081-1. PMID: 8633962
Inflammatory pseudotumour (plasma cell granuloma) of lung, liver and other organs.
Anthony PP
Histopathology 1993 Nov;23(5):501-3. doi: 10.1111/j.1365-2559.1993.tb00508.x. PMID: 8314233
Childhood primary pulmonary neoplasms.
Hancock BJ, Di Lorenzo M, Youssef S, Yazbeck S, Marcotte JE, Collin PP
J Pediatr Surg 1993 Sep;28(9):1133-6. doi: 10.1016/0022-3468(93)90147-d. PMID: 8308677
Primary pulmonary tumors in childhood: a review of 31 years' experience and the literature.
Cohen MC, Kaschula RO
Pediatr Pulmonol 1992 Dec;14(4):222-32. doi: 10.1002/ppul.1950140405. PMID: 1336597

Therapy

Syphilitic Pulmonary Inflammatory Pseudotumor: A Diagnostic Challenge.
Govender D, Jackson C, Chetty D
Int J Surg Pathol 2021 Feb;29(1):90-96. Epub 2020 Jun 2 doi: 10.1177/1066896920928584. PMID: 32486870
Pulmonary Mycobacterium Spindle Cell Pseudotumor in Patient With Liver Transplant.
Chesdachai S, Udompap P, Li F, Lake JR, Kc M
Am J Med Sci 2020 Jan;359(1):42-50. Epub 2019 Nov 5 doi: 10.1016/j.amjms.2019.10.016. PMID: 31902440
Surgical resection of pulmonary inflammatory pseudotumors: long-term outcome.
Peretti M, Radu DM, Pfeuty K, Dujon A, Riquet M, Martinod E
Asian Cardiovasc Thorac Ann 2017 Jul;25(6):440-445. Epub 2017 Jun 12 doi: 10.1177/0218492317716587. PMID: 28605954
Pulmonary inflammatory pseudotumor due to Coxiella burnetii. Case report and literature review.
Polo MF, Mastrandrea S, Santoru L, Arcadu A, Masala G, Marras V, Bagella G, Sechi MM, Tanda F, Pirina P
Microbes Infect 2015 Nov-Dec;17(11-12):795-8. Epub 2015 Sep 3 doi: 10.1016/j.micinf.2015.08.008. PMID: 26342254
Pulmonary plasma cell granuloma improves with corticosteroid therapy.
Bando T, Fujimura M, Noda Y, Hirose J, Ohta G, Matsuda T
Chest 1994 May;105(5):1574-5. doi: 10.1378/chest.105.5.1574. PMID: 8181356

Prognosis

Plasma cell granuloma involving the brain and the lung.
Greiner C, Rickert CH, Möllmann FT, Rieger B, Semik M, Heindel W, Wassmann H
Acta Neurochir (Wien) 2003 Dec;145(12):1127-31. Epub 2003 Sep 22 doi: 10.1007/s00701-003-0109-z. PMID: 14663572
Plasma cell granuloma of the lung: difficulties in diagnosis and prognosis.
Copin MC, Gosselin BH, Ribet ME
Ann Thorac Surg 1996 May;61(5):1477-82. doi: 10.1016/0003-4975(96)00081-1. PMID: 8633962
Inflammatory pseudotumour (plasma cell granuloma) of lung, liver and other organs.
Anthony PP
Histopathology 1993 Nov;23(5):501-3. doi: 10.1111/j.1365-2559.1993.tb00508.x. PMID: 8314233
Childhood primary pulmonary neoplasms.
Hancock BJ, Di Lorenzo M, Youssef S, Yazbeck S, Marcotte JE, Collin PP
J Pediatr Surg 1993 Sep;28(9):1133-6. doi: 10.1016/0022-3468(93)90147-d. PMID: 8308677
Primary pulmonary tumors in childhood: a review of 31 years' experience and the literature.
Cohen MC, Kaschula RO
Pediatr Pulmonol 1992 Dec;14(4):222-32. doi: 10.1002/ppul.1950140405. PMID: 1336597

Clinical prediction guides

Pulmonary inflammatory myofibroblastic tumor: a case report.
Tsuchiya T, Tanaka M
Asian Cardiovasc Thorac Ann 2018 May;26(4):317-319. Epub 2018 Apr 12 doi: 10.1177/0218492318770845. PMID: 29649880
Prolonged B cell depletion with rituximab is effective in treating refractory pulmonary granulomatous inflammation in granulomatosis with polyangiitis (GPA).
Henderson SR, Copley SJ, Pusey CD, Ind PW, Salama AD
Medicine (Baltimore) 2014 Dec;93(27):e229. doi: 10.1097/MD.0000000000000229. PMID: 25501085Free PMC Article
Pulmonary inflammatory myofibroblastic tumor and IgG4-related inflammatory pseudotumor: a diagnostic dilemma.
Bhagat P, Bal A, Das A, Singh N, Singh H
Virchows Arch 2013 Dec;463(6):743-7. Epub 2013 Oct 8 doi: 10.1007/s00428-013-1493-2. PMID: 24100523
Pulmonary inflammatory pseudotumor--a report of 28 cases.
Kim JH, Cho JH, Park MS, Chung JH, Lee JG, Kim YS, Kim SK, Kim SK, Shin DH, Choi BW, Choe KO, Chang J
Korean J Intern Med 2002 Dec;17(4):252-8. doi: 10.3904/kjim.2002.17.4.252. PMID: 12647641Free PMC Article
Seven patients with plasma cell granuloma (inflammatory pseudotumor) of the lung, including two with intrabronchial growth: an immunohistochemical and electron microscopic study.
Nonomura A, Mizukami Y, Matsubara F, Shimizu J, Oda M, Watanabe Y, Kamimura R, Takashima T, Kitagawa M
Intern Med 1992 Jun;31(6):756-65. doi: 10.2169/internalmedicine.31.756. PMID: 1392177

Recent systematic reviews

Parenchymal pseudotumoral tuberculosis: case series and systematic review of literature.
Agarwal R, Srinivas R, Aggarwal AN
Respir Med 2008 Mar;102(3):382-9. Epub 2007 Dec 3 doi: 10.1016/j.rmed.2007.10.017. PMID: 18060757

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